In a study published in Cancer Cell on July 2, Dr. QIN Jun's group from Shanghai Institute of Nutrition and Health (SINH) of the Chinese Academy of Sciences (CAS), and the collaborators revealed that H3K36 methyltransferase SETD2 curtails the level of EZH2 to inhib...

Researchers at the Shanghai Institute of Nutrition and Health of Chinese Academy of Sciences discovered a critical role of succinate in promoting beige adipogenesis of adipose precursor cells, providing a new potential target for the treatment of obesity and relate...

A translational research team led by Prof. WANG Yuexiang at the Shanghai Institute of Nutrition and Health of Chinese Academy of Sciences performed whole exome sequencing and reported recurrent genomic inactivated DEPDC5 gene mutations in GISTs. They showed that DE...

A recent study published in Nature demonstrated that DNA base editors generated tens of thousands of off-target RNA single nucleotide variants (SNVs) and these off-target SNVs could be eliminated by introducing point mutations to the deaminases. This work revealed ...

Prof. PAN Weijun’s group at the Shanghai Institute of Nutrition and Health, of the Chinese Academy of Sciences used a zebrafish model to analyze the entire dynamic process of HSPC homing in vivo. This study dissects the temporal-spatial rules of HSPC retention, pr...

A team of Chinese scientists have shown the unique structure of circular RNAs (circRNAs) and their binding and regulation of the innate immune double-stranded RNA(dsRNA)-activated protein kinase (PKR). Importantly, misregulation of circRNA on PKR is found in patien...