Researchers from SINH and SIMM of CAS jointly revealed a novel DNA-sensing pathway in aged CD4+ T cells that is independent on cGAS/STING, which promotes T cell activation and proliferation and leads to the development of aging-associated autoimmune diseases.

A recent study by Dr. HU Guohong's group showed that CTSC secretion is associated with breast cancer lung metastasis both in breast cancer cell lines and clinical samples. It revealed that CTSC promotes lung metastasis of breast cancer, by regulating neutrophil inf...

In a study published in Cancer Cell on July 2, Dr. QIN Jun's group from Shanghai Institute of Nutrition and Health (SINH) of the Chinese Academy of Sciences (CAS), and the collaborators revealed that H3K36 methyltransferase SETD2 curtails the level of EZH2 to inhib...

Researchers at the Shanghai Institute of Nutrition and Health of Chinese Academy of Sciences discovered a critical role of succinate in promoting beige adipogenesis of adipose precursor cells, providing a new potential target for the treatment of obesity and relate...

A translational research team led by Prof. WANG Yuexiang at the Shanghai Institute of Nutrition and Health of Chinese Academy of Sciences performed whole exome sequencing and reported recurrent genomic inactivated DEPDC5 gene mutations in GISTs. They showed that DE...

A recent study published in Nature demonstrated that DNA base editors generated tens of thousands of off-target RNA single nucleotide variants (SNVs) and these off-target SNVs could be eliminated by introducing point mutations to the deaminases. This work revealed ...