Chinese Scientists Develop a Metastatic Dormancy Lineage Tracing System and Reveal the Effect of Chemotherapy on Dormancy Awakening

Scientists from SINH developed a novel recombinase-based lineage tracing system, DormTracer, which enables researchers to directly observe the awakening of disseminated tumor cells after persistent dormancy and investigate the effect of chemotherapeutic drugs durin...

Researchers Reveal Novel Mechanism Behind Host and Microbiota Interaction

A recent research published online in Nature revealed how a host protein can specifically recognize bacterial lipids and stimulate beneficial immune responses. Researchers uncovered a novel mechanism by which apolipoprotein-dependent recognition of sphingolipids me...

Researchers Reveal Key Mechanism Behind Bacterial Cancer Therapy

Early Ancestral Bottleneck Could’ve Spelled the End for Modern Humans

An unexplained gap in the African/Eurasian fossil record may now be explained thanks to a team of researchers from China, Italy and the United States. Using a novel method called FitCoal (fast infinitesimal time coalescent process), the researchers were able to acc...

Researchers Reveal Key Mechanism of Bone Metastasis Tropism in Luminal Breast Cancer

A research team led by Prof. HU Guohong from SINH revealed the crucial role of SCUBE2 in regulating bone metastasis of luminal breast cancer, and supports its significance in clinical diagnosis and in bone metastasis treatment.

Scientists Reveal Mechanism of Direct Osteoclast-to-tumor Stimulus for Lung Cancer Bone Metastasis

In a recent study by Prof. HU Guohong's group from SINH and collaborators found that osteoclast-derived IL19 could directly regulate the proliferation of lung cancer cells in bone through tumor-expressed IL20RB. This study elucidated a mechanism of direct osteoclas...