Researchers Reveal Key Mechanism Behind Bacterial Cancer Therapy

Early Ancestral Bottleneck Could’ve Spelled the End for Modern Humans

An unexplained gap in the African/Eurasian fossil record may now be explained thanks to a team of researchers from China, Italy and the United States. Using a novel method called FitCoal (fast infinitesimal time coalescent process), the researchers were able to acc...

Researchers Reveal Key Mechanism of Bone Metastasis Tropism in Luminal Breast Cancer

A research team led by Prof. HU Guohong from SINH revealed the crucial role of SCUBE2 in regulating bone metastasis of luminal breast cancer, and supports its significance in clinical diagnosis and in bone metastasis treatment.

Scientists Reveal Mechanism of Direct Osteoclast-to-tumor Stimulus for Lung Cancer Bone Metastasis

In a recent study by Prof. HU Guohong's group from SINH and collaborators found that osteoclast-derived IL19 could directly regulate the proliferation of lung cancer cells in bone through tumor-expressed IL20RB. This study elucidated a mechanism of direct osteoclas...

Natural Antiaging Compound Found in Grape Seeds with Lifespan-extending Effects

In a study published in Nature Metabolism on Dec. 6th, 2021, researchers from Shanghai Institute of Nutrition and Health of Chinese Academy of Sciences, conducted a large scale investigation with plant-derived medicinal agents, and revealed that a natural compound ...

Scientists Reveal New DNA-sensing Pathway in CD4+ T Cells and Regulatory Mechanism in Mediating Aging-related Autoimmune Disease

Researchers from SINH and SIMM of CAS jointly revealed a novel DNA-sensing pathway in aged CD4+ T cells that is independent on cGAS/STING, which promotes T cell activation and proliferation and leads to the development of aging-associated autoimmune diseases.