A team of Chinese scientists have shown the unique structure of circular RNAs (circRNAs) and their binding and regulation of the innate immune double-stranded RNA(dsRNA)-activated protein kinase (PKR). Importantly, misregulation of circRNA on PKR is found in patien...

Prof. QIAN Youcun’s group of the Shanghai Institute of Nutrition and Health (SINH) of Chinese Academy of Sciences (CAS), published their latest research in the international academic journal Immunity on February 26, 2019. The study systematically analyzed the micr...

In a News and Views commentary entitled “To BE or not to BE, that is the question”, Dr. YANG Li and collaborators commented three recent studies published in Science and Nat Biotechnol about accuracy of base editing. In the commentary, authors indicated that the ...

Researchers developed a method named “GOTI”, abbreviated by “Genome-wide Off-target Analysis by Two-cell Embryo Injection”. The research team applied the method to evaluate the genome-wide off-target effects induced by genome editing tools including CRISPR/Cas9...

Researchers from Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences found that Listeria monocytogenes promoted its own survival by inducing mitochondrial autophagy (mitophagy) in macrophages and identified a new mitophagy receptor NLRX1....

A recent research by Shanghai Institute of Nutrition and Health, CAS demonstrate that a low oxygen culture condition could enhance the therapeutic effects of MSCs on autoimmune diseases by up-regulating the secretion of insulin like growth factor-2. This study reve...