A research team from the Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health (SINH) of Chinese Academy of Sciences (CAS), and their collaborators from CAS Center for Excellence in Molecular Plant Sciences developed Registry and Database of Bioparts for Synthetic Biology (RDBSB, https://www.biosino.org/rdbsb).

Entitled “RDBSB: a database for catalytic bioparts with experimental evidence”, this study was published in Nucleic Acids Research on October 3^rd, 2024.

Catalytic bioparts are fundamental to the design, construction and optimization of biological systems for specific metabolic pathways. However, the functional characterization information of these bioparts is frequently dispersed across multiple databases and literature sources, posing significant challenges to the effective design and optimization of specific chassis or cell factories.

RDBSB is designed and developed to be the first comprehensive resource for catalytic bioparts in synthetic biology. It contains 83,193 catalytic bioparts with experimental evidences and offers their detailed qualitative and quantitative catalytic information, including critical parameters such as activities, substrates, optimal pH and temperature, and chassis specificity. The platform features an interactive search engine, visualization tools and analysis utilities such as biopart finder, structure prediction and pathway design tools.

"RDBSB promotes community engagement through a catalytic bioparts submission system to facilitate rapid data sharing and utilization. In fact, it has already supported the contribution of more than 1,000 catalytic bioparts so far." said Prof. ZHANG Guoqing, corresponding author of this article, "It will significantly enhance the resources available for pathway design in synthetic biology and serve essential tools for researchers."

Online analysis served by RDBSB. (Image provided by Prof. Zhang’s team)

Media Contact:
WANG Jin
Shanghai Institute of Nutrition and Health,
Chinese Academy of Sciences
Email: wangjin01@sinh.ac.cn
Web: http://english.sinh.cas.cn/