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Core Facilities

The Center for Public Technical Service of SINH offers high-efficiency and high-quality technical services to support scientific research. It comprises the following technical platforms: 

1. Public Testing Technical Platform
1.1 Mass Spectrometry Subplatform
1.2 Molecular Biology and Biochemistry Subplatform
1.3 Cell Analysis Subplatform
1.4 Pathological Analysis of Biological Samples Subplatform
   

2. Laboratory Animal Technical Platform 

3. Computational Biology Technical Platform
3.1 Omics Subplatform
3.2 Uli Schwarz Quantitative Biology Subplatform
3.3 High Performance Storage and Computing Subplatform 
 

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1. Public Testing Technical Platform 

This platform comprises four subplatforms staffed by 16 technicians. It provides analytical services at the molecular, cellular and organismic levels related to research on nutritional metabolism, stem cells, tumors and immunity.   

1.1 Mass Spectrometry Subplatform 

Provides analytical services related to metabolomics, proteomics, molecular biology and food nutrition, as well as support for drug development, nutritional intervention, food safety research and other related work.   

The platform has the following instruments:   

Category 

Type 

4000 Q Trap LC-MS/MS 

Orbitrap Velos Pro 

Thermo Finnigan TSQ VANTAGE LC-MS/MS 

Agilent 7700X 

IsoPrime100 Isotope Ratio Mass Spectrometer 

4000 Q Trap 

TripleTOF 6600 LC-MS/MS 

Thermo Finnigan TSQ VANTAGE 

6890N-5975B inert XL EI/CI GC-MSD 

IsoPrime100 

4000 Q Trap LC-MS/MS 

TripleTOF 6600 

Thermo Finnigan TSQ VANTAGE LC-MS/MS 

6890N-5975B inert XL EI/CI MSD 

Contact: LI Zi  Tel: 86-21-5492 0929

1.2 Molecular Biology and Biochemistry Subplatform 

Provides genetic analysis of disease genes, analysis of metabolomics and proteomics, as well as support for drug development, nutritional intervention and food safety research, etc.  

The platform has the following instruments: 

Category 

Type 

RT-PCR AB 7900HT 

7900HT 

RT-PCR AB 7900 

AB7900 

nCounter Analysis System 

nCounter Analysis System 

RT-PCR Roche 480 

Roche 480 

RT-PCR AB 7900 

ABI 7900-384 

RT-PCR AB Q7 

ABI Q7 

Microplate Reader PE EnSpire 

PE EnSpire 

RT-PCR MX3000P-96 

MX3000P-96 

RT-PCR AB StepOnePlus 

StepOnePlus 

RT-PCR AB VIIA7 

VIIA7 

Microplate Reader BioTek Synergy 

BioTek Synergy 

QIAsymphony Sample Preparation System, Qiagen 

Qiagen 

Genomics 10X  

Genomics 10X 

Contact: ZHAO Feng  Tel: 86-21-5492 0938 

 1.3 Cell Analysis Subplatform  

Includes a flow cytometry laboratory, biological micro-imaging laboratory and stem cell laboratory. It provides technical services involving stem cells, cell sorting, cell analysis, cell morphology and cell function, etc.  

The platform has the following instruments: 

Category 

Type 

Flow Cell Sorter, Beckman MOFLO ASTRIOS 

MOFLO ASTRIOS 

Flow Cell Sorter, Beckman Moflo Astrios 

Beckman Moflo Astrios 

Flow Cell Sorter, BD SORP FACSAria 

BD SORP FACSAria 

Cytometer, Beckman Quanta SC  

BECKMAN 

Cytometer, Beckman Gallios 

Gallios 

Flow Cell Sorter, BD FACS AriaII  

BD FACS Aria_  

Cytometer, Beckman Quanta SC 

Quanta SC 

Flow Cell Sorter, Beckman Moflo EQ 

Beckman Moflo EQ 

Cytometer, Beckman CytoFLEX 

BECKMAN 

Cytometer, Beckman CytoFLEX 

BECKMAN 

Confocal, Zeiss LSM880NLO FLIM 

Zeiss LSM880NLO FLIM 

Confocal, Zeiss LSM710 Cell Observer 

Cell Observer 

High Content System Operetta 

Operetta 

Cytometer, Millipore Guava 12HT 

Guava 12HT 

XF24 Extracellular Flux Analyzer 

XF24 

HCS, Thermo ArrayScan VTI Infinity 

ArrayScan VTI Infinity 

Contact:
LIAO Xiang  Tel: 86-21-5492 3323
QIU Lin  Tel: 86-21-5492 0936      

1.4 Pathological Analysis of Biological Samples Subplatform  

Houses a high-quality library of tumor samples in line with international standards and provides related pathology analysis.  

The platform has the following instruments: 

Category 

Type 

Vectra 2 automated quantitative pathology imaging system 

PerkinElmer Vectra 2

Automatic Immuno Histochemical System 

Thermo 

Contact: SUN Weihong  Tel: 86-21-5497 1225  

2. Laboratory AnimalTechnical Platform 

Provides laboratory animal services including feeding management, guidance for operating instruments and training in technologies related to laboratory animals, etc. It also provides technical support for animal experiments including:  1) technical consultation; 2) guidance on operations, breeding genetically modified mice and operating large equipment; 3) management of specific-pathogen-free (SPF) laboratory animal rooms; 4) guidance on laboratory animal welfare, etc. The platform has a staff of 18 technicians. At present, there are four sub-facilities for SPF-class mice and rats, including 13,000 mice cages and 100 rat cages.   

The platform has the following instruments:   

Category 

Type 

Contact Person 

Tel. 

High-Resolution Digital Specimen X-ray Imaging System 

Faxitron MX-20 DC12 

WANG Kai 

5492-3329 

NightOWL in vivo Imaging System 

LB983 NC100 

WANG Kai 

5492-3329 

High-Resolution Ultrasound Imaging System 

vevo2100 

WANG Kai 

5492-3329 

High-Resolution Ultrasound Imaging System 

Vevo2100 

WANG Cheng 
YU Lili 

5492-0541
5492-0755
 

in vivo Imaging System 

  

WANG Cheng
YU Lili   

5492-0541
5492-0755
 

Mouse Telemetry Implants 

DSI/Moor 

YU Lili 

5492-0755 

Minispec mq10 analyzer 

Minispec mq10 

WANG Cheng 

5492-0541 

Body Composition Analyzers for Live Small Animals (Mice) and Organs 

Bruke 

WENG Zhonghui
YU Lili   

5492-0538
5492
-0755 

Comprehensive lab animal monitoring system 

CLAMS-8 

WANG Cheng 

5492-0541 

Comprehensive lab animal monitoring system 

CLAMS-16 

WENG Zhonghui
YU Lili   

5492-0538
5492
-0755 

Comprehensive lab animal monitoring system 

CLAMS-16 

WANG Cheng 

5492-3329 

3. Computational Biology Technical Platform    

The Computational Biology Core Facility promotes the development of SINH’s Biomedical Big Data Center and has three subplatforms staffed by eight technicians.  

3.1 Omics Subplatform 

Provides both library preparation and subsequent high-throughput, deep-sequencing services. Featuring high-throughput, fast, long-segment and single-cell sequencing, the subplatform offers services from library separation and sequencing to bioinformatics processing in order to meet researchers’ different sequencing needs. 

The platform has the following instruments: 

Category 

Type 

illumina Hiseq sequencer  

illumina Hi-seq 2000 

illumina NextSeq sequencer  

illumina NextSeq500 

NanoPore ultralong sequencer 

Oxford Nanopore 

Genomics 10X 

Genomics 10X 

Contact: XIN Changpeng Tel: 86-21-54920545

3.2 Uli Schwarz Quantitative Biology Subplatform 

To commemorate Prof. Uli Schwarz and his great contribution to Sino-German scientific collaboration, the public central lab of the CAS-MPG Partner Institute of Computational Biology (PICB), an outgrowth of the former Max-Planck Guest Lab founded by Prof. Schwarz in 1985, was renamed the Uli Schwarz Quantitative Biology Core Facility. This facility mainly supplies high-throughput genetic, phenotypic and metabolic data, as well as data on aging, facial imaging, and big tissue 3D-imaging for computational modeling and analysis. It also provides wet lab infrastructure to verify dry data modeling.   

The platform has the following instruments:   

Category 

Type 

Fluorescence real-time quantitative PCR  

Roche LC480 

High-throughput gene analysis system 

Fluidigm Biomark HD 

Multifunctional microplate reader 

Bio-Tek Synergy H1 

High-throughput metabolic enzyme platform 

PE Janus 8 

Microfluidic chip technology platform 

ABM/6/350/DCCD/M;EMCCD Evolve 512 

High efficiency ultrasonic breaker 

Covaris S220 

3D multifunctional imaging system 

Visio Sphere 3D+ 

Living cell workstation 

ZEISS Axio observer Z1 

Laser capture microdissection system 

ABI Arcturus XT 

Two-photon laser scanning confocal microscope 

Zeiss LSM 880 NLO 

Lightsheet microscopic imaging system 

Zeiss lightsheet Z1 

Contact: CHEN Yujie    Tel: 86-21-5492 0415  

3.3 High Performance Storage and Computing Subplatform 

This subplatform is one of the earliest HPC platforms for computational biology at SINH. It is the only support platform dedicated to file storage services, computing resource services, flexible web hosting services and server hosting services at SINH. Over 100 computing nodes are provided inside the HPC cluster and peak performance is close to 50 TFLOPS. The cluster is equipped with general computing nodes, 2TB big memory computing nodes and GPU-accelerated nodes, all of which deliver supercomputing power that directly supports scientific research. Several sets of NAS provide more than 5PB of storage space. The platform provides high-level computing performance and storage for massive omics, phenotypic and image data storage and analysis. 

Contact:  MA Liangxiao Tel: 86-21-5492 0468