| Author |
Yu, J; Gui, XQ; Zou, YH; Liu, Q; Yang, ZC; An, JS; Guo, X; Wang, KH; Guo, JM; Huang, MN; Zhou, SH; Zuo, J; Chen, YM; Deng, L; Yuan, GW; Li, N; Song, Y; Jia, J; Zeng, J; Zhao, YX; Liu, XM; Du, XX; Liu, YS; Wang, P; Zhang, B; Ding, L; Robles, AI; Rodriguez, H; Zhou, H; Shao, Z; Wu, LY; Gao, DM |
| Abstract |
Although the incidence of cervical cancer (CC) has been reduced in high-income countries due to human papillomavirus (HPV) vaccination and screening strategies, it remains a significant public health issue that poses a threat to women's health in low-income countries. Here, we perform a comprehensive proteogenomic profiling of CC tumors obtained from 139 Chinese women. Integrated proteogenomic analysis links genetic aberrations to downstream pathogenesis-related pathways and reveals the landscape of HPV-associated multi-omic changes. EP300 is found to enhance the acetylation of FOSL2-K222, consequently accelerating the malignant proliferation of CC cells. Proteomic stratification identifies three patient subgroups with distinct features in prognosis, genetic alterations, immune infiltration, and post-translational modification regulations. PRKCB is further identified as a potential radioresponse-related biomarker of CC patients. This study provides a valuable public resource for researchers and clinicians to delve into the molecular basis of CC, to identify potential treatments and to ultimately advance clinical practice. Cervical cancer remains a significant public health problem in many regions. Here, the authors perform a proteogenomic analysis of cervical cancer in Chinese patients; they reveal proteomic subgroups associated with clinical and biological features, and a potential biomarker of response to radiotherapy. |
