Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer
| Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer | |
| Author | Hanling Wang, Ni Li, Qiuli Liu, Jiacheng Guo, Qiang Pan, Bisheng Cheng, Junyu Xu, Baijun Dong, Guanjie Yang, Bin Yang, Xuege Wang, Yongqiang Gu, Guoying Zhang, Yannan Lian, Wei Zhang, Mingyu Zhang,Tianyi Li, Yi Zang, Minjia Tan, Qintong Li, Xiaoming Wang, Zhengquan Yu, Jun Jiang*, Hai Huang*, Jun Qin* |
| Journal | CANCER CELL |
| Pub Year | 2023 |
| Type | Article |
| Abstract | Wang et al. show that the polarization of cancer-associated fibroblasts(CAFs) is shaped collaboratively by the tumor microenvironment(TME) and target therapy. AR inhibition unleashes TGF-β signaling to convert inflammatory CAFs into SPP1* myofibroblastic CAFs and targeting of CAF polarization or paracrine mechanisms may restrain castration resistant in prostate cancer. |
| Issue | 41 |
| Volume | 41 |
| SCI | 50.3 |