| Prevalent stroke, age of its onset, and post-stroke lifestyle in relation to dementia: A prospective cohort study |
| Author |
Zhong, WS; Chen, H; Gong, XX; Tong, LS; Xu, X; Zong, G; Yuan, CZ; Lou, M |
| Journal |
ALZHEIMERS & DEMENTIA |
| Pub Year |
2023 |
| Type |
Article; Early Access |
| Abstract |
INTRODUCTIONThe association of age at stroke onset with dementia and the role of post-stroke lifestyle on dementia risk remains unclear. METHODSWe leveraged data of 496,251 dementia-free participants from UK Biobank and explored the relationship between age at stroke onset and incident dementia. Among 8328 participants with stroke history, we further investigated the association of a healthy lifestyle with risk of dementia. RESULTSParticipants with stroke history had a higher risk of dementia (hazard ratio [HR], 2.02). The association was stronger among participants with stroke onset at a younger age (<= 50: HR, 2.63) compared with those at the age > 50 years (50-60: HR, 2.17; >= 60: HR, 1.58). Among participants with stroke history, a favorable lifestyle was associated with a lower risk of incident dementia. DISCUSSIONStroke onset in earlier life stage predicted a higher risk for dementia, but a favorable post-stroke lifestyle may protect against dementia. |
| SCI |
14 |
