| Reciprocal regulation of mesenchymal stem cells and immune responses |
| Author |
Wang, Y; Fang, JK; Liu, BM; Shao, CS; Shi, YF |
| Journal |
CELL STEM CELL |
| Pub Year |
2022 |
| Type |
Review |
| Abstract |
Mesenchymal stem/stromal cells (MSCs) exist in almost all tissues and participate in tissue regeneration and homeostasis. In-vitro-expanded MSCs are employed as therapeutics for autoimmune diseases, organ fail-ures, and many other chronic disorders. Remarkably, the reparative and homeostatic maintenance functions of MSCs rely on their interaction with the inflammatory microenvironment. Here, we discuss the characteris-tics and functions of MSCs under different pathophysiological conditions and highlight how the immunomod-ulatory functions of MSCs are altered in accordance with the inflammatory cues. We hope to provide new insights into the diverse immunoregulatory properties of MSCs during tissue regeneration and therapy. |
| Issue |
29 |
| Volume |
29 |
