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Core Facilities
Institutional Center for Shared Technologies and Facilities of SINH, CAS offers high-efficiency and high-quality technical services to support scientific research. It comprises the following technical platforms:
1. Public Testing Technical Platform
1.1 Mass Spectrometry Subplatform
1.2 Molecular Biology and Biochemistry Subplatform
1.3 Cell Analysis Subplatform
1.4 Pathological Analysis of Biological Samples Subplatform
2. Laboratory Animal Technical Platform
3. Computational Biology Technical Platform
3.1 Omics Subplatform
3.2 Uli Schwarz Quantitative Biology Subplatform
3.3High Performance Storage and Computing Subplatform
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1. Public Testing Technical Platform
This platform comprises four subplatforms staffed by 16 technicians. It provides analytical services at the molecular, cellular and organismic levels related to research on nutritional metabolism, stem cells, tumors and immunity.
1.1 Mass Spectrometry Subplatform
Provides analytical services related to metabolomics, proteomics, molecular biology and food nutrition, as well as support for drug development, nutritional intervention, food safety research and other related work.
The platform has the following instruments:
|
Category |
Type |
|
4000 Q Trap LC-MS/MS |
Orbitrap Velos Pro |
|
Thermo Finnigan TSQ VANTAGE LC-MS/MS |
Agilent 7700X |
|
IsoPrime100 Isotope Ratio Mass Spectrometer |
4000 Q Trap |
|
TripleTOF 6600 LC-MS/MS |
Thermo Finnigan TSQ VANTAGE |
|
6890N-5975B inert XL EI/CI GC-MSD |
IsoPrime100 |
|
4000 Q Trap LC-MS/MS |
TripleTOF 6600 |
|
Thermo Finnigan TSQ VANTAGE LC-MS/MS |
6890N-5975B inert XL EI/CI MSD |
Contact: LI Zi Tel: 86-21-5492 0929
1.2 Molecular Biology and Biochemistry Subplatform
Provides genetic analysis of disease genes, analysis of metabolomics and proteomics, as well as support for drug development, nutritional intervention and food safety research, etc.
The platform has the following instruments:
|
Category |
Type |
|
RT-PCR AB 7900HT |
7900HT |
|
RT-PCR AB 7900 |
AB7900 |
|
nCounter Analysis System |
nCounter Analysis System |
|
RT-PCR Roche 480 |
Roche 480 |
|
RT-PCR AB 7900 |
ABI 7900-384 |
|
RT-PCR AB Q7 |
ABI Q7 |
|
Microplate Reader PE EnSpire |
PE EnSpire |
|
RT-PCR MX3000P-96 |
MX3000P-96 |
|
RT-PCR AB StepOnePlus |
StepOnePlus |
|
RT-PCR AB VIIA7 |
VIIA7 |
|
Microplate Reader BioTek Synergy |
BioTek Synergy |
|
QIAsymphony Sample Preparation System, Qiagen |
Qiagen |
|
Genomics 10X |
Genomics 10X |
Includes a flow cytometry laboratory, biological micro-imaging laboratory and stem cell laboratory. It provides technical services involving stem cells, cell sorting, cell analysis, cell morphology and cell function, etc.
The platform has the following instruments:
|
Category |
Type |
|
Flow Cell Sorter, Beckman MOFLO ASTRIOS |
MOFLO ASTRIOS |
|
Flow Cell Sorter, Beckman Moflo Astrios |
Beckman Moflo Astrios |
|
Flow Cell Sorter, BD SORP FACSAria |
BD SORP FACSAria |
|
Cytometer, Beckman Quanta SC |
BECKMAN |
|
Cytometer, Beckman Gallios |
Gallios |
|
Flow Cell Sorter, BD FACS AriaII |
BD FACS Aria_ |
|
Cytometer, Beckman Quanta SC |
Quanta SC |
|
Flow Cell Sorter, Beckman Moflo EQ |
Beckman Moflo EQ |
|
Cytometer, Beckman CytoFLEX |
BECKMAN |
|
Cytometer, Beckman CytoFLEX |
BECKMAN |
|
Confocal, Zeiss LSM880NLO FLIM |
Zeiss LSM880NLO FLIM |
|
Confocal, Zeiss LSM710 Cell Observer |
Cell Observer |
|
High Content System Operetta |
Operetta |
|
Cytometer, Millipore Guava 12HT |
Guava 12HT |
|
XF24 Extracellular Flux Analyzer |
XF24 |
|
HCS, Thermo ArrayScan VTI Infinity |
ArrayScan VTI Infinity |
QIU Lin Tel: 86-21-5492 0936
1.4 Pathological Analysis of Biological Samples Subplatform
Houses a high-quality library of tumor samples in line with international standards and provides related pathology analysis.
The platform has the following instruments:
|
Category |
Type |
|
Vectra 2 automated quantitative pathology imaging system |
PerkinElmer Vectra 2 |
|
Automatic Immuno Histochemical System |
Thermo |
Contact: SUN Weihong Tel: 86-21-5497 1225
2. Laboratory AnimalTechnical Platform
Provides laboratory animal services including feeding management, guidance for operating instruments and training in technologies related to laboratory animals, etc. It also provides technical support for animal experiments including: 1) technical consultation; 2) guidance on operations, breeding genetically modified mice and operating large equipment; 3) management of specific-pathogen-free (SPF) laboratory animal rooms; 4) guidance on laboratory animal welfare, etc. The platform has a staff of 18 technicians. At present, there are four sub-facilities for SPF-class mice and rats, including 13,000 mice cages and 100 rat cages.
The platform has the following instruments:
|
Category |
Type |
Contact Person |
Tel. |
|
High-Resolution Digital Specimen X-ray Imaging System |
Faxitron MX-20 DC12 |
WANG Kai |
5492-3329 |
|
NightOWL in vivo Imaging System |
LB983 NC100 |
WANG Kai |
5492-3329 |
|
High-Resolution Ultrasound Imaging System |
vevo2100 |
WANG Kai |
5492-3329 |
|
High-Resolution Ultrasound Imaging System |
Vevo2100 |
WANG Cheng |
5492-0541 |
|
in vivo Imaging System |
|
WANG Cheng |
5492-0541 |
|
Mouse Telemetry Implants |
DSI/Moor |
YU Lili |
5492-0755 |
|
Minispec mq10 analyzer |
Minispec mq10 |
WANG Cheng |
5492-0541 |
|
Body Composition Analyzers for Live Small Animals (Mice) and Organs |
Bruke |
WENG Zhonghui |
5492-0538 |
|
Comprehensive lab animal monitoring system |
CLAMS-8 |
WANG Cheng |
5492-0541 |
|
Comprehensive lab animal monitoring system |
CLAMS-16 |
WENG Zhonghui |
5492-0538 |
|
Comprehensive lab animal monitoring system |
CLAMS-16 |
WANG Cheng |
5492-3329 |
3. Computational Biology Technical Platform
The Computational Biology Core Facility promotes the development of SINH’s Biomedical Big Data Center and has three subplatforms staffed by eight technicians.
Provides both library preparation and subsequent high-throughput, deep-sequencing services. Featuring high-throughput, fast, long-segment and single-cell sequencing, the subplatform offers services from library separation and sequencing to bioinformatics processing in order to meet researchers’ different sequencing needs.
The platform has the following instruments:
|
Category |
Type |
|
illumina Hiseq sequencer |
illumina Hi-seq 2000 |
|
illumina NextSeq sequencer |
illumina NextSeq500 |
|
NanoPore ultralong sequencer |
Oxford Nanopore |
|
Genomics 10X |
Genomics 10X |
Contact: Tel: 86-21-54920545
3.2 Uli Schwarz Quantitative Biology Subplatform
To commemorate Prof. Uli Schwarz and his great contribution to Sino-German scientific collaboration, the platform was renamed as the Uli Schwarz Quantitative Biology Core Facility. This facility mainly supplies high-throughput genetic, phenotypic and metabolic data, as well as data on aging, facial imaging, and big tissue 3D-imaging for computational modeling and analysis. It also provides wet lab infrastructure to verify dry data modeling.
The platform has the following instruments:
|
Category |
Type |
|
Fluorescence real-time quantitative PCR |
Roche LC480 |
|
High-throughput gene analysis system |
Fluidigm Biomark HD |
|
Multifunctional microplate reader |
Bio-Tek Synergy H1 |
|
High-throughput metabolic enzyme platform |
PE Janus 8 |
|
Microfluidic chip technology platform |
ABM/6/350/DCCD/M;EMCCD Evolve 512 |
|
High efficiency ultrasonic breaker |
Covaris S220 |
|
3D multifunctional imaging system |
Visio Sphere 3D+ |
|
Living cell workstation |
ZEISS Axio observer Z1 |
|
Laser capture microdissection system |
ABI Arcturus XT |
|
Two-photon laser scanning confocal microscope |
Zeiss LSM 880 NLO |
|
Lightsheet microscopic imaging system |
Zeiss lightsheet Z1 |
3.3 High Performance Storage and Computing Subplatform
This subplatform is one of the earliest HPC platforms for computational biology at SINH. It is the only support platform dedicated to file storage services, computing resource services, flexible web hosting services and server hosting services at SINH. Over 100 computing nodes are provided inside the HPC cluster and peak performance is close to 50 TFLOPS. The cluster is equipped with general computing nodes, 2TB big memory computing nodes and GPU-accelerated nodes, all of which deliver supercomputing power that directly supports scientific research. Several sets of NAS provide more than 5PB of storage space. The platform provides high-level computing performance and storage for massive omics, phenotypic and image data storage and analysis.
Contact: MA Liangxiao Tel: 86-21-5492 0468