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SHI Yufang

Ph.D.

Guest Professor

Email: shiyufang2@gmail.com

Brief Biography : 

Education: 

1977 - 1982, Veterinary Medicine, Department of Veterinary Medicine, Shandong Agricultural University, Shandong, China. 

1983 - 1984, Advanced studies in Vertebrate Zoology, Embryology, Cell Biology, Comparative Anatomy, Mammalian studies, and Ornithology, at Department of Zoology, Shandong University, China. 

1984 - 1985, Advanced study in English, Bell Educational Trust (UK), Ministry of Agriculture and Fishery, China. 

1985 - 1988, M.Sc., Department of Zoology, University of Alberta, Edmonton, Alberta, Canada.  

1988 - 1992, Ph.D., Department of Immunology, University of Alberta. 

Post Doctoral Training: 

1992 - 1995, Department of Immunology, University of Toronto, Toronto, Ontario, Canada.  

Academic Background: 

1982.1 - 1985. 9, Teaching Staff in Fundamentals of Zoology course, Department of Veterinary Medicine, Shandong Agricultural University, Taian, China. 

1986.9 - 1989.5, Teaching Assistant, first year courses in Zoology and Physiology, Department of Zoology, University of Alberta, Canada. 

1995.2 - 1999.6, Scientist I (equivalent to Assistant Professor), Department of Immunology, Holland Laboratory of the American Red Cross. 

1995.7 - 1999.7, Assistant Professor and Member of the Graduate Programs of Immunology, Biochemistry, and Oncology, Department of Microbiology and Immunology, George Washington University(as per agreement between George Washington University and the American Red Cross, according to which, faculty at the Holland Lab also had full appointment at the Medical School of George Washington University). 

1999.7 - 2001.8, Tenured Associate Professor (with 20% effort), Department of Immunology, George Washington University. 

1999.7 - 2001.8, Tenured Scientist II (equivalent to Tenured Associate Professor), Department of Immunology, Holland Laboratory of the American Red Cross. 

2001.8 - 2003.6, Tenured Associate Professor with University Professorship, Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey (later merged with Rutgers University). 

2003.7- Present, Tenured Full Professor with Tenure and a University Professor title, Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, Rutgers University. 

2001.8 - Present, Member, Rurgers Cancer Institute of New Jersey. 

2001 - 2009, Member, Infection, Immunology and Hematology Team, National Space Biomedical Research Institute, NASA. 

2004.6 - 2008, Member, Graduate Program in Molecular Pharmacology, Joint Graduate Program in Molecular Biosciences, Robert Wood Johnson Medical School and Rutgers University. 

2008 - 2014, Director，Professor，Principal Investigator，Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiaotong University School of Medicine, Shanghai, China. 

2009, Chief Scientific Officer for Translational Research, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. 

2008 - 2016, Professor，Principal Investigator，Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiaotong University School of Medicine, Shanghai, China. 

2017 - Present Guest Professor, Shanghai Institute of Nutrition and Health (SINH), CAS 

 

Research Areas:

1. Immunoregulation of Mesenchymal Stem Cells (MSCs): MSCs actively regulate the process of tissue repair. Injured tissue always accompanies with inflammation. Thus, it is necessary to explore the relationship between MSCs and immune cells. We have found that the immunomodulation of MSCs is endowed by certain inflammatory cytokines. Also, there is plasticity of MSC immunomodulation. Such process is decided by the presence of different amounts and kinds of inflammatory cytokines which are in dynamic changes during the initiation and progression of inflammatory diseases;

2. Immunomodulation in Tumour: Immunosurveillance is critical in controlling tumour development and progression. Tumour immunotherapy is a therapy applied to treat tumor patients that shapes the immune system to fight against tumor. Our studies are focusing on the formation and regulation of immune responses in the tumour stroma;

3. Immune metabolism: Immune cells opt for distinct metabolic pathways to exert either pro-inflammatory or anti-inflammatory functions. We aim to illustrate how metabolic pathways dictating immune cell function and develop new strategies to target immunometabolism in autoimmune diseases.

4. Activation Induced Cell Death (AICD) of Different T cell Subpopulation: We are investigating on the potential mechanisms of AICD in different T cell subpopulation.

 

Selected Publications:(#Co-first Author *Corresponding Author)

  1. Zhang X#, Wang Y#, Song J#, Gerwien H, Chuquisana O, Chashchina A, Denz C, Sorokin L. The endothelial basement membrane- a check point for entry of pathogenic T cells into the brain. Journal of Experimental Medicine in press.
  2. Liu K, Lin L, Li Q, Xue Y, Zheng F, Wang G, Zheng C, Du L, Hu M, Shao C, Kong X, Melino G, Shi Y*, Wang Y*. Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II. Proc Natl Acad Sci U S A 2020 Feb 4;117(5):2462-2472.
  3. Nicolai, Pieraccioli M, Smirnov A, Pitolli C, Anemona L, Mauriello A, Candi E, Annicchiarico-Petruzzelli M, Shi Y, Wang Y, Melino G., Raschella G. ZNF281/Zfp281 Is a Target of miR-1 and Counteracts Muscle Differentiation. Mol Oncol 2020 Feb;14(2):294-308.
  4. Pitolli C, Wang Y, Mancini M, Shi Y, Melino G, Amelio I., Do Mutations Turn p53 Into an Oncogene? Int J Mol Sci 2019 Dec 11;20(24). pii: E6241.
  5. Pitolli C, Wang Y, Mancini M, Shi Y, Candi E., Melino G, Amelio I.p53-Mediated Tumor Suppression: DNA-Damage Response and Alternative Mechanisms. Cancers (Basel) 2019 Dec 9;11(12). pii: E1983.
  6. Li XL, Liu R, Su X, Pan YS, Han XF*, Shao CS*, Shi Y*. Harnessing Tumor-Associated Macrophages as Aids for Cancer Immunotherapy. Mol Cancer 2019 Dec 5;18(1):177.
  7. Lanna C, Mancini M, Gaziano R, Cannizzaro MV, Galluzzo M, Talamonti M, Rovella V, Annicchiarico-Petruzzelli M, Melino G, Wang Y, Shi Y, Campione E, Bianchi L. Skin immunity and its dysregulation in psoriasis. Cell Cycle 2019 Oct;18(20):2581-2589.
  8. Jiang Y, Li C, Wu Q, An P, Huang L, Wang J, Chen C, Chen X, Zhang F, Ma L, Liu S, He H, Xie S, Sun Y, Liu H, Zhan Y, Tao Y, Liu Z, Sun X, Hu Y, Wang Q, Ye D, Zhang J, Zou S, Wang Y, Wei G, Liu Y, Shi Y, Eugene Chin Y, Hao Y, Wang F, Zhang X. Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses. Nat Commun 2019 Jul 3;10(1):2935.
  9. Gong Z, Shang B, Chu Y, Chen X, Li Q, Liu K, Chen Y, Huang Y, Han Y, Shang Q, Zheng Z, Song L, Li Y, Liu R, Xu C, Zhang X, Liu B, Wang L*, Shao C*, Wang Y*, Shi Y*. Fibrotic liver microenvironment promotes Dll4 and SDF-1-dependent T-cell lineage development. Cell Death Dis 2019 Jun 5;10(6):440.
  10. Huang Y, Li Q, Zhang K, Hu M, Wang Y, Du L, Lin L, Li S, Sorokin L, Melino G, Shi Y*, Wang Y*. Single cell transcriptomic analysis of human mesenchymal stem cells reveals limited heterogeneity. Cell Death Dis 2019 May 8;10(5):368.
  11. Fibbe WE*, Shi Y*. FOXO3, a Molecular Search for the Fountain of Youth. Cell Stem Cell 2019 Mar 7;24(3):351-352.
  12. Du L, Lin L, Li Q, Liu K, Huang Y, Wang X, Cao K, Chen X, Cao W, Li F, Shao C, Wang Y*, Shi Y*. IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties. Cell Metab 2019 Jun 4;29(6):1363-1375.e8.
  13. Huang L, Xu C, Xu P, Qin Y, Chen M, Feng Q, Pan J, Cheng Q, Liang F, Wen X, Wang Y, Shi Y, Cheng Y. Intelligent Photosensitive Mesenchymal Stem Cells and Cell-Derived Microvesicles for Photothermal Therapy of Prostate Cancer. Nanotheranostics 2018 Nov 11;3(1):41-53.
  14. Li X, Shang B, Li YN, Shi Y*, Shao C*. IFNγ and TNFα synergistically induceapoptosis of mesenchymal stem/stromal cells via the induction of nitric oxide. Stem Cell Res Ther 2019 Jan 11;10(1):18.
  15. Yi S, Zhai J, Niu R, Zhu G, Wang M, Liu J, Huang H, Wang Y, Jing X, Kang L, Song W, Shi Y, Tang H. Eosinophil recruitment is dynamically regulated byinterplay among lung dendritic cell subsets after allergen challenge. Nat Commun 2018 Sep 24;9(1):3879.
  16. Li X, Song W, Shao C, Shi Y*, Han W*. Emerging predictors of the response to the blockade of immune checkpoints in cancer therapy. Cell Mol Immunol 2019 Jan;16(1):28-39.
  17. Shi Y*, Wang Y, Li Q, Liu K, Hou J, Shao C, Wang Y*. Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases. Nat Rev Nephrol 2018 Aug;14(8):493-507.
  18. Chen Y, Liu K, Shi Y, Shao C. The tango of ROS and p53 in tissue stem cells. Cell Death Differ 2018 Mar;25(4):639-641.
  19. Galluzzi L, et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ 2018 Mar;25(3):486-541.
  20. Wang G, Cao K, Liu K, Xue Y, Roberts AI, Li F, Han Y, Rabson AB, Wang Y*, Shi Y*. Kynurenic acid, an IDO metabolite, controls TSG-6-mediated immunosuppression of human mesenchymal stem cells. Cell Death Differ 2018 Jul;25(7):1209-1223.
  21. Shi Y, Du LM, Lin LY, Wang Y. Tumor associated mesenchymal stem/stromal cells: emerging therapeutic targets. Nat Rev Drug Discov 2017 Jan;16(1):35-52.
  22. Yu P, Huang Y, Xu C, Lin L, Han Y, Sun W, Hu G, Rabson A, Wang Y*, Shi Y*. Downregulation of CXCL12 in Mesenchymal Stromal Cells by TGFβ Promotes Breast Cancer Metastasis. Oncogene 2017 Feb 9;36(6):840-849.
  23. Yu P, Huang Y, Han Y, Lin L, Rabson A, Wang Y*, Shi Y*. TNFα-activated Mesenchymal Stromal Cells Promote Breast Cancer Metastasis through Recruiting CXCR2+ Neutrophils. Oncogene 2017 Jan 26;36(4):482-490.
  24. Lin L, Du L, Cao K, Huang Y, Yu P, Zhang L, Li F, Wang Y*, Shi Y*. Tumour cell-derived exosomes endow mesenchymal stromal cells with tumour-promotion capabilities. Oncogene 2016 Nov 17;35(46):6038-6042.
  25. Shou P, Chen Q, Jiang J, Xu C, Zhang J, Zheng C, Jiang M, Velletri T, Cao W, Huang Y, Yang Q, Han X, Zhang L, Wei L, Rabson AB, Chin YE, Wang Y*, Shi Y*. Type I Interferons Exert Anti-tumor Effect via Reversing Immunosuppression Mediated by Mesenchymal Stromal Cells. Oncogene 2016 Nov 17;35(46):5953-5962.
  26. Jiang M, Zheng C, Shou P, Li N, Cao G, Chen Q, Xu C, Du L, Yang Q, Cao J, Han Y, Li F, Cao W, Zhang L, Wang Y*, Shi Y*. SHP1 Regulates Bone Mass by Directing Mesenchymal Stem Cell Differentiation. Cell Rep 2016 Jul 19;16(3):769-780.
  27. Chen Q, Shou P, Zheng C, Jiang M, Cao G, Yang Q, Cao J, Xie N, Velletri T, Zhang X, Xu C, Zhang L, Yang H, Hou J, Wang Y*, Shi Y*. Fate decision of mesenchymal stem cells: adipocytes or osteoblasts? Cell Death Differ 2016 Jul;23(7):1128-1139.
  28. Zheng C, Yang Q, Cao J, Xie N, Liu K, Shou P, Qian F, Wang Y*, Shi Y*. Local proliferation initiates macrophage accumulation in adipose tissue during obesity. Cell Death Dis 2016 Mar 31;7:e2167.
  29. Velletri T, Xie N, Wang Y, Huang Y, Yang Q, Chen X, Chen Q, Shou P, Gan Y, Cao G, Melino G, Shi Y*. P53 functional abnormality in mesenchymal stem cells promotes osteosarcoma development. Cell Death Dis 2016 Jan 21;7:e2015.
  30. Galipeau J, Krampera M, Barrett J, Dazzi F, Deans RJ, DeBruijn J, Dominici M, Fibbe WE, Gee AP, Gimble JM, Hematti P, Koh MB, LeBlanc K, Martin I, McNiece IK, Mendicino M, Oh S, Ortiz L, Phinney DG, Planat V, Shi Y, Stroncek DF, Viswanathan S, Weiss DJ Sensebe L. International Society for Cellular Therapy perspective on immune functional assays for mesenchymal stromal cells as potency release criterion for advanced phase clinical trials. Cytotherapy 2016 Feb;18(2):151-159.
  31. Liu Y, Yang X, Jing Y, Zhang S, Zong C, Jiang J, Sun K, Li R, Gao L, Zhao X, Wu D, Shi Y, Han Z, Wei L. Contribution and Mobilization of Mesenchymal Stem Cells in a mouse model of carbon tetrachloride-induced liver fibrosis. Sci Rep 2015 Dec 8;5:17762.
  32. Zhou Y, Wu K, Jiang J, Huang J, Zhang P, Zhu Y, Hu G, Lang J, Shi Y, Hu L, Huang T, Kong X. Integrative analysis reveals enhanced regulatory effects of human long intergenic non-coding RNAs in lung adenocarcinoma. J Genet Genomics 2015 Aug 20;42(8):423-436.
  33. Zheng C, Yang Q, Xua C, Shou P, Cao J, Jiang M, Chen Q, Cao G, Han Y, Li F, Cao W, Zhang L, Zhang L, Shi Y*, Wang Y*. CD11b Regulates Obesity-Induced Insulin Resistance via Limiting Alternative Activation and Proliferation of Adipose Tissue Macrophages. Proc Natl Acad Sci U S A 2015 Dec 29;112(52):E7239-E7248.
  34. Shi Y, Cao J, Wang Y. Rethinking regeneration: empowerment of stem cells by inflammation. Cell Death Differ 2015 Dec;22(12):1891-1892.
  35. Cheng Y, Wang B, Zhou H, Dang S, Jin M, Shi Y, Hao L, Yang Z, Zhang Y. Autophagy is Required for the Maintenance of Liver Progenitor Cell Functionality. Cell Physiol Biochem 2015;36(3):1163-1174.
  36. Liu Z, Cao W, Xu L, Chen X, Zhan Y, Yang Q, Liu S, Chen P, Jiang Y, Sun X, Tao Y, Hu Y, Li C, Wang Q, Wang Y, Chen CD*, Shi Y*, Zhang X*. The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation. J Mol Cell Biol 2015 Dec;7(6):505-516.
  37. Cao K, Wang G, Li W, Zhang L, Wang R, Huang Y, Du L, Jiang J, Wu C, He X, Roberts AI, Li F, Rabson AB, Wang Y*, Shi Y*. Histone deacetylase inhibitors prevent activation-induced cell death and promote anti-tumor immunity. Oncogene 2015 Dec 3;34(49):5960-5970.
  38. Zhu K, Zhang N, Guo N, Yang J, Wang J, Yang C, Yang C, Zhu L, Xu C, Deng Q, Zhu R, Wang H, Chen X, Shi Y, Li Y*, Leng Q*. SSC(high)CD11b(high)Ly-6C(high)Ly-6G(low) myeloid cells curtail CD4 T cell response by inducible nitric oxide synthase in murine hepatitis. Int J Biochem Cell Biol 2014 Sep;54:89-97.
  39. Cao W, Cao K, Cao J, Wang Y, Shi Y*. Mesenchymal stem cells and adaptive immune responses. Immunol Lett 2015 Dec;168(2):147-153.
  40. Chen F, Zhuang X, Lin L, Yu P, Wang Y, Shi Y, Hu G, Sun Y. New horizons in tumor microenvironment biology: challenges and opportunities. BMC Med 2015 Mar 5;13:45. doi: 10.1186/s12916-015-0278-7.
  41. Khan I, Zhang L, Mohammed M, Archer FE, Abukharmah J, Yuan Z, Rizvi SS, Melek MG, Rabson AB, Shi Y, Weinberger B, Vetrano AM. Effects of Wharton's jelly-derived mesenchymal stem cells on neonatal neutrophils. J Inflamm Res 2014 Dec 31;8:1-8.
  42. Wang Y, Chen X, Cao W, Shi Y*. Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications. Nat Immunol 2014 Nov;15(11):1009-1016.
  43. Zhang M, Zhou H, Zheng C, Xiao J, Zuo E, Liu W, Xie D, Shi Y, Wu C, Wang H, Li D, Li J. The roles of testicular c-kit positive cells in de novo morphogenesis of testis. Sci Rep 2014 Aug 4;4:5936.
  44. Yin S, Yang J, Lin B, Deng W, Zhang Y, Yi X, Shi Y, Tao Y, Cai J, Wu CI, Zhao G, Hurst LD, Zhang J, Hu L, Kong X. Exome sequencing identifies frequent mutation of MLL2 in non-small cell lung carcinoma from Chinese patients. Sci Rep 2014 Aug 12;4:6036.
  45. Shi Y*. The 1000th publication features protection of normal cells during chemotherapy: a land mark for Cell Death & Disease. Cell Death Dis 2014 Feb 13;5:e1062.
  46. Han X, Yang Q, Lin L, Xu C, Zheng C, Chen X, Han Y, Li M, Cao W, Cao K, Chen Q, Xu G, Zhang Y, Zhang J, Schneider RJ, Qian Y, Wang Y*, Brewer G*, Shi Y*. Interleukin-17 enhances immunosuppression by mesenchymal stem cells. Cell Death Differ 2014 Nov;21(11):1758-1768.
  47. Ma S, Xie N, Li W, Yuan B, Shi Y*, Wang Y*. Immunobiology of mesenchymal stem cells. Cell Death Differ 2014 Feb;21(2):216-225.
  48. Zhang Y, Cai W, Huang Q, Gu Y, Shi Y, Huang J, Zhao F, Liu Q, Wei X, Jin M, Wu C, Xie Q, Zhang Y, Wan B, Zhang Y. Mesenchymal stem cells alleviate bacteria-induced liver injury in mice by inducing regulatory dendritic cells. Hepatology 2014 Feb;59(2):671-682.
  49. Zhu K, Zhang N, Guo N, Yang J, Wang J, Yang C, Yang C, Zhu L, Xu C, Deng Q, Zhu R, Wang H, Chen X, Shi Y, Li Y, Leng Q. SSC(high)CD11b(high)Ly-6C(high)Ly-6G(low) myeloid cells curtail CD4 T cell response by inducible nitric oxide synthase in murine hepatitis. Int J Biochem Cell Biol 2014 Sep;54:89-97.
  50. Yang X, Han Z, Zhang S, Zhu P, Hao C, Fan T, Yang Y, Li L, Shi Y*, Wei L*. Chronic restraint stress decreases the repair potential from mesenchymal stem cells on liver injury by inhibiting TGF-β1 generation. Cell Death Dis 2014 Jun 26;5:e1308.
  51. Liu S, Sun X, Wang M, Hou Y, Zhan Y, Jiang Y, Liu Z, Cao X, Chen P, Liu Z, Chen X, Tao Y, Xu C, Mao J, Cheng C, Li C, Hu Y, Wang L, Chin YE, Shi Y,, Siebenlist U, Zhang X. A microRNA miR-221- and miR-222-mediated feedback loop, via PDLIM2, maintains constitutive activation of nuclear factor κB and STAT3 in colorectal cancer cells. Gastroenterology 2014 Oct;147(4):847-859.e11.
  52. Ke F, Zhang L, Liu Z, Liu J, Yan S, Xu Z, Bai J, Zhu H, Lou F, Wang H, Shi Y, Jiang Y, Su B, Wang H. Autocrine IL-6 drives skin-derived mesenchymal stem cell trafficking via regulating voltage-gated Ca(2+) channels. Stem Cells 2014 Oct;32(10):2799-810.
  53. Cao G, Yang Q, Zhang SY, Xu CL, Roberts, AI, Wang Y*, Shi Y*. Mesenchymal stem cells prevent restraint stress-induced lymphocyte depletion via interleukin-4. Brain Behav Immun 2014 May;38:125-132.
  54. Chen X, Gan Y, Li W, Su J, Zhang Y, Huang Y, Roberts AI, Han Y, Li J, Wang Y, Shi Y*. The interaction between mesenchymal stem cells and steroids during inflammation. Cell Death Dis 2014 Jan 23;5:e1009.
  55. Ling W, Zhang J, Yuan Z, Ren G, Zhang L, Chen X, Rabson AB, Roberts AI, Wang Y, Shi Y*. Mesenchymal stem cells use IDO to regulate immunity in tumor microenvironment. Cancer Res 2014 Mar 1;74(5):1576-87.
  56. Song X, Gao H, Lin Y, Yao Y, Zhu S, Wang J, Liu Y, Yao X, Meng G, Shen N, Shi Y, Iwakura Y, Qian Y. Alterations in the Microbiota Drive Interleukin-17C Production from Intestinal Epithelial Cells to Promote Tumorigenesis. Immunity 2014 Jan 16;40(1):140-152.
  57. Xu C, Yu P, Han X, Du L, Gan J, Wang Y, Shi Y*. TGF-β Promotes Immune Responses in the Presence of Mesenchymal Stem Cells. J Immunol 2014 Jan 1;192(1):103-109.
  58. Ren G, Liu Y, Zhao X, Zhang J, Zheng B, Yuag Z, Zhang L, Tischfield J, Shao C*, Shi Y*. Tumor resident mesenchymal stromal cells endow na？ve stromal cells with tumor-promoting properties. Oncogene 2014 Jul 24;33(30):4016-4020.
  59. Huang Y, Yu P, Li W, Ren G, Roberts, AI, Cao W, Zhang X, Su J, Chen X, Chen Q, Shou P, Xu C, Du L, Lin L, Zhang L, Xie N, Wang Y*, Shi Y*. p53 regulates mesenchymal stem cell-mediated tumor suppression in a tumor microenvironment through immune modulation. Oncogene 2014 Jul 17;33(29):3830-8.
  60. Su J, Chen X, Huang Y, Li W, Li J, Cao K, Cao G, Zhang L, Li F, Roberts AI, Kang H, Yu P, Ren G, Ji W, Wang Y*, Shi Y*. Phylogenetic distinction of iNOS and IDO function in mesenchymal stem cell-mediated immunosuppression in mammalian species. Cell Death Differ 2014 Mar;21(3):388-396.
  61. Chen Q, Shou P, Zhang L, Xu C, Zheng C, Han Y, Li W, Huang Y, Zhang X, Shao C, Roberts AI, Rabson AB, Ren G, Zhang Y, Wang Y, Denhardt DT, Shi Y*. An Osteopontin-Integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells. Stem Cells 2014 Feb;32(2):327-337.
  62. Hou J, Han Z, Jing Y, Yang X, Zhang S, Sun K, Hao C, Meng Y, Yu F, Liu X, Shi Y, Wu M, Zhang L, Wei LX. Autophagy prevents irradiation injury and maintains stemness through decreasing ROS generation in mesenchymal stem cells. Cell Death Dis 2013 Oct 10;4:e844.
  63. Xu C, Lin L, Cao G, Chen Q, Shou P, Huang Y, Han Y, Wang Y*, Shi Y*. Interferon-α-secreting mesenchymal stem cells exert potent antitumor effect in vivo. Oncogene 2014 Oct 16;33(42):5047-5052.
  64. Chen P, Zhang J, Zhan Y, Su J, Du Y, Xu G, Shi Y, Siebenlist U, Zhang X. Established thymic epithelial progenitor/stem cell-like cell lines differentiate into mature thymic epithelial cells and support T cell development. PLoS One 2013 Sep 23;8(9):e75222.
  65. Zhang J, Liu C, Roberts AI, Xu G, REN G, Zhang L, Devadas S* and Shi Y*. A novel subset of helper T cells promotes immune responses by secreting GM-CSF. Cell Death Differ 2013 Dec;20(12):1731-41.
  66. Wu Q, Wang H, Zhao X, Shi Y, Jin M, Wan B, Xu H, Cheng Y, Ge H, Zhang Y. Identification of G-protein-coupled receptor 120 as a tumor-promoting receptor that induces angiogenesis and migration in human colorectal carcinoma. Oncogene 2013 Dec 5;32(49):5541-5550.
  67. Yu B, He Z, You P, Han Q, Xiang D, Chen F, Wang M, Liu C, Lin X, Borjigin U, Zi X, Li J, Zhu H, Li W, Han C, Wangensteen KJ, Shi Y, Hui L, Wang X, Hu Y. Reprogramming fibroblasts into bipotential hepatic stem cells by defined factors. Cell Stem Cell 2013 Sep 5;13(3):328-340.
  68. Liu B*, Chen X, Wang Y, Shi Y*. Curative effect of hepatic portal venous administration of autologous bone marrow in AIDS patients with decompensated liver cirrhosis. Cell Death Dis 2013 Jul 25;4:e739.
  69. Phinney DG, Galipeau J, Krampera M, Martin I, Shi Y, Sensebe L. MSCs: science and trials. Nat Med 2013 Jul;19(7):812.
  70. Wei X, Yang X, Han Z, Qu F, Shao L*, Shi Y*. Mesenchymal stem cells: a new trend for cell therapy. Acta Pharmacol Sin 2013 Jun;34(6):747-754.
  71. Xu C, Ren G, Cao G, Chen Q, Shou P, Zheng C, Du L, Han X, Jiang M, Yang Q, Lin L, Wang G, Yu P, Zhang X, Cao W, Brewer G, Wang Y*, Shi Y*. MiR-155 regulates immune modulatory properties of mesenchymal stem cells by targeting TAK1-binding protein 2. J Biol Chem 2013 Apr 19;288(16):11074-11079.
  72. Krampera M, Galipeau J, Shi Y, Tarte K, Sensebe L. MSC Committee of the International Society for Cellular Therapy (ISCT). Immunological characterization of multipotent mesenchymal stromal cells - The International Society for Cellular Therapy (ISCT) working proposal. Cytotherapy 2013 Sep;15(9):1054-1061.
  73. Wu X, Chesoni S, Rondeau G, Tempesta C, Patel R, Charles S, Daginawala N, Zucconi BE, Kishor A, Xu G, Shi Y, Li ML, Barreto PI, Welsh J, Wilson GM, Brewer G. Combinatorial mRNA binding by AUF1 and Argonaute 2 controls decay of selected target mRNAs. Nucleic Acids Res 2013 Feb 1;41(4):2644-2658.
  74. Yang X, Hou J, Han Z, Wang Y, Hao C, Wei L*, Shi Y*. One cell, multiple roles: contribution of mesenchymal stem cells to tumor development in tumor microenvironment. Cell Biosci 2013 Jan 21;3(1):5.
  75. Liu Z, Jiang Y, Hou Y, Hu Y, Cao X, Tao Y, Xu C, Liu S, Wang S, Wang L, Shi Y, Siebenlist U, Zhang X. The IκB family member Bcl-3 stabilizes c-Myc in colorectal cancer. J Mol Cell Biol2013 Aug;5(4):280-2.
  76. Zeng A, Li Y, Wang C, Han X, Li G, Wang JY, Li D, Qin Y, Shi Y, Brewer G, Jing Q. Heterochromatin protein 1 promotes self-renewal and triggers regenerative proliferation in adult stem cells. J Cell Biol 2013 Apr 29;201(3):409-25.
  77. Lang JY, Shi Y, Chin YE. Reprogramming cancer cells: back to the future. Oncogene 2013 May 2;32(18):2247-2248.
  78. Ren G, Zhao X, Wang Y, Zhang X, Chen X, Xu C, Yuan Z, Roberts A, Zhang L, Zheng B, Wen T, Han Y, Rabson A, Tischfield J, Shao C, Shi Y*. CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFα. Cell Stem Cell2012 Dec 7;11(6):812-824.
  79. Qu F, Gao H, Zhu S, Shi P, Zhang Y, Liu Y, Jallal B, Yao Y, Shi Y, Qian Y. TRAF6-dependent Act1 phosphorylation by the IκB kinase-related kinases suppresses interleukin-17-induced NF-κB activation. Mol Cell Biol 2012 Oct;32(19):3925-3937.
  80. L'huillier A, Ren G, Shi Y*, Zhang J*. A two-hit model of autoimmunity: lymphopenia and unresponsiveness to TGF-β signaling. Cell Mol Immunol 2012 Sep;9(5):369-370.
  81. Zhu S, Pan W, Song X, Liu Y, Shao X, Tang Y, Liang D, He D, Wang H, Liu W, Shi Y, Harley JB, Shen N, Qian Y. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. Nat Med 2012 Jul;18(7):1077-1086.
  82. Yao Y, Wang Y, Chen F, Huang Y, Zhu S, Leng Q, Wang H, Shi Y, Qian Y. NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens. Cell Res 2012 May;22(5):836-847.
  83. Li W, Ren G, Huang Y, Su J, Han Y, Li J, Chen X, Cao K, Chen Q, Shou P, Zhang L, Yuan ZR, Roberts AI, Shi S, Le AD, Shi Y*. Mesenchymal stem cells: a double-edged sword in regulating immune responses. Cell Death Differ 2012 Sep;19(9):1505-1513.
  84. Han Z, Jing Y, Zhang S, Liu Y, Shi Y*, Wei L*. The role of immunosuppression of mesenchymal stem cells in tissue repair and tumor growth. Cell Biosci 2012 Mar 5;2(1):8.
  85. Shi Y*, Su J, Roberts AI, Shou P, Rabson AB, Ren G*. How mesenchymal stem cells interact with tissue immune responses. Trends Immunol 2012 Mar;33(3):136-143.
  86. Sensebé L, Tarte K, Galipeau J, Krampera M, Martin I, Phinney DG, Shi Y. Limited Acquisition of Chromosomal Aberrations in Human Adult Mesenchymal Stromal Cells. Cell Stem Cell 2012 Jan 6;10(1):9-10; author reply 10-1. doi: 10.1016/j.stem.2011.12.005.
  87. Shi Y*, Wei L, Wang Y, Ren G. Stem Cells Deployed for Bone Repair Hijacked by T Cells. Cell Stem Cell 2012 Jan 6;10(1):6-8.
  88. Ren G, Chen X, Dong F, Li W, Ren X, Zhang Y, Shi Y*. Concise review: mesenchymal stem cells and translational medicine: emerging issues. Stem Cells Transl Med 2012 Jan;1(1):51-58.
  89. Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV, Dawson TM, Dawson VL, El-Deiry WS, Fulda S, Gottlieb E, Green DR, Hengartner MO, Kepp O, Knight RA, Kumar S, Lipton SA, Lu X, Madeo F, Malorni W, Mehlen P, Nunez G, Peter ME, Piacentini M, Rubinsztein DC, Shi Y, Simon HU, Vandenabeele P, White E, Yuan J, Zhivotovsky B, Melino G, Kroemer G. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ 2012 Jan;19(1):107-120.
  90. Han Z, Tian Z, Lv G, Zhang L, Jiang G, Sun K, Wang C, Bu X, Li R, Shi Y, Wu M, Wei L. Immunosuppressive effect of bone marrow‐derived mesenchymal stem cells in inflammatory microenvironment favours the growth of B16 melanoma cells. J Cell Mol Med 2011 Nov;15(11):2343-52. doi: 10.1111/j.1582-4934.2010.01215.x.
  91. Shi P, Zhu S, Lin Y, Liu Y, Liu Y, Chen Zn, Shi Y, Qian Y. Persistent Stimulation with Interleukin-17 Desensitizes Cells Through SCFβ-TrCP-Mediated Degradation of Act1. Sci Signal 2011 Nov 1;4(197):ra73. doi: 10.1126/scisignal.2001653.
  92. Song X, Zhu S, Shi P, Liu Y, Shi Y, Levin SD, Qian Y. IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens. Nat Immunol 2011 Oct 12;12(12):1151-8. doi: 10.1038/ni.2155.
  93. Cao W, Yang Y, Wang Z, Liu A, Fang L, Wu F, Hong J, Shi Y, Leung S, Dong C, Zhang JZ. Leukemia Inhibitory Factor Inhibits T Helper 17 Cell Differentiation and Confers Treatment Effects of Neural Progenitor Cell Therapy in Autoimmune Disease. Immunity 2011 Aug 26;35(2):273-84. doi: 10.1016/j.immuni.2011.06.011.
  94. Krause CD, Izotova LS, Ren G, Yuan ZR, Shi Y, Chen CC, Ron Y, Pestka S. Efficient co-expression of bicistronic proteins in mesenchymal stem cells by development and optimization of a multifunctional plasmid. Stem Cell Res Ther 2011 Mar 14;2(2):15. doi: 10.1186/scrt56.
  95. Yamaza T, Ren G, Akiyama K, Chen C, Shi Y, Shi S. Mouse mandible contains distinctive mesenchymal stem cells. J Dent Res 2011 Mar;90(3):317-24. doi: 10.1177/0022034510387796.
  96. Zhao F, Zhang Y, Wang H, Jin M, S, He S, Shi Y, Guo Y, Zhang Y. Blockade of osteopontin reduces alloreactive CD8+ T cell-mediated graft-versus-host disease. Blood 2011 Feb 3;117(5):1723-33. doi: 10.1182/blood-2010-04-281659.
  97. Ren G, Roberts AI, Shi Y*. Adhesion molecules: key players in mesenchymal stem cell-mediated immunosuppression. Cell Adh Migr 2011 Jan-Feb;5(1):20-2. doi: 10.4161/cam.5.1.13491.
  98. Hu G, Ren G, Shi Y*. The putative cannabinoid receptor GPR55 promotes cancer cell proliferation. Oncogene 2011 Jan 13;30(2):139-41. doi: 10.1038/onc.2010.502.
  99. Zhu S, Pan W, Shi P, Gao H, Zhao F, Song X, Liu Y, Zhao L, Li X, Shi Y, Qian Y. Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling. J Exp Med 2010 Nov 22;207(12):2647-62. doi: 10.1084/jem.20100703.
  100. Swaims AY, Khani F, Zhang Y, Roberts AI, Devadas S, Shi Y*, Rabson AB*. Immune activation induces immortalization of HTLV-1 LTR-Tax transgenic CD4+ T cells. Blood 2010 Oct 21;116(16):2994-3003. doi: 10.1182/blood-2009-07-231050.
  101. Arriola A, Kiel ME, Shi Y, McKinnon RD. Adjunctive MSCs enhance myelin formation by xenogenic oligodendrocyte precursors transplanted in the retina. Cell Res 2010 Jun;20(6):728-31. doi: 10.1038/cr.2010.63.
  102. Shi Y*, Hu GZ, Su JJ, Li WZ, Chen Q, Shou PS, Xu CL, Chen XD, Huang Y, Zhu ZX, Huang X, Han XY, Xie NX, Ren GW. Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair. Cell Res 2010 May;20(5):510-8. doi: 10.1038/cr.2010.44.
  103. Ye W, Gong X, Xie J, Wu J, Zhang X, Ouyang Q, Zhao X, Shi Y, Zhang X. AChE deficiency or inhibition decreases apoptosis and p53 expression and protects renal function after ischemia/reperfusion. Apoptosis 2010 Apr;15(4):474-87. doi: 10.1007/s10495-009-0438-3.
  104. Yamaza T, Kentaro A, Chen C, Liu Y, Shi Y, Gronthos S, Wang S, Shi S. Immunomodulatory properties of stem cells from human exfoliated deciduous teeth. Stem Cell Res Ther 2010 Mar 15;1(1):5. doi: 10.1186/scrt5.
  105. Ren GW, Zhao X, Zhang LY, Zhang JM, L'Huillier A, Ling WF, Roberts AI, Le AD, Shi ST, Shao CS, and Shi Y*. Inflammatory Cytokine-Induced Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1 in Mesenchymal Stem Cells Are Critical for Immunosuppression. J Immunol 2010 Mar 1;184(5):2321-8. doi: 10.4049/jimmunol.0902023.
  106. Markovina S, Callander NS, O′Connor SL, Xu G, Shi Y, Leith CP, Kim K, Trivedi P, Kim J, Hematti P, Miyamoto S. Bone marrow stromal cells from multiple myeloma patients uniquely induce bortezomib resistant NF-kappaB activity in myeloma cells. Mol Cancer 2010 Jul 6;9:176. doi: 10.1186/1476-4598-9-176.
  107. Zhao X, Ren GW, Liang L, Zheng B, Tischfield JA, Shi Y*, Shao CS*. Brief report: IFN-γ induces expansion of Lin-Sca-1+C-Kit+ Cells. Stem Cells 2010 Jan;28(1):122-6. doi: 10.1002/stem.252.
  108. Zhang Q, Shi S, Liu Y, Uyanne J, Shi Y, Shi S, Le AD. Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis. J Immunol 2009 Dec 15;183(12):7787-98. doi: 10.4049/jimmunol.0902318.
  109. Das J, Ren GW, Zhang LY, Roberts IA, Zhao X, Bothwel ALM, Kaer LV, Shi Y*, Das G*. Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation. J Exp Med 2009 Oct 26;206(11):2407-16. doi: 10.1084/jem.20082286.
  110. Izotova LS, Krause CD, Ren G, Yuan ZR, Shi Y, Pestka S. PP2-014 Visualizing engineered interferon-producing cells with multicistronic vectors and fluorescent proteins. Abstracts/Cytokine 2009, 48:91-137. Doi: 10.1016/j.cyto.2009.07.392.
  111. Kong L, Sun L, Zhang H, Liu Q, Liu Y, Qin L, Shi G, Hu JH, Xu A, Sun YP, Li D, Shi Y, Zang JW, Zhu J, Chen Z, Wang ZG, Ge BX. An essential role for RIG-I in toll-like receptor-stimulated phagocytosis. Cell Host Microbe 2009 Aug 20;6(2):150-61. doi: 10.1016/j.chom.2009.06.008.
  112. Ren G, Su J, Zhang L, Zhao X, Ling W, L′huillie A, Zhang J, Lu Y, Roberts AI, Ji W, Rabson AB, Shi Y*. Species Variation in the Mechanisms of Mesenchymal Stem Cell-Mediated Immunosuppression. Stem Cells 2009 Aug;27(8):1954-62. doi: 10.1002/stem.118.
  113. Shi Y, Zhu J, Salomoni P, Tucci P, Lu X. A Sino-British frontier workshop of cancer biology. Cell Death Differ 2009 Apr;16(4):648-50. doi: 10.1038/cdd.2008.192.
  114. Vavassori S, Shi Y, Chen CC, Ron Y, Covey LR. In vivo post-transcriptional regulation of CD154 in mouse CD4+ T cells. Eur J Immunol 2009 Aug;39(8):2224-32. doi: 10.1002/eji.200839163.
  115. Xu G, Zhang Y, Zhang L, Roberts, A.I., Shi Y*. C/EBPβ Mdiates Synergistic Upregulation of Gene Expression by IFNγ and TNFα in Bone Marrow-Derived Mesenchymal Stem Cells. Stem Cells 2009 April;27(4):942–948. doi:10.1002/stem.22.
  116. Wang KX, Shi Y, Ron Y, Kazanecki CC, Denhardt DT. Plasma osteopontin modulates chronic restraint stress-induced thymus atrophy by regulating stress hormones: inhibition by an anti-osteopontin monoclonal antibody. J Immunol 2009 Feb 15;182(4):2485-91. doi: 10.4049/jimmunol.0803023.
  117. Qian Y, Shi Y*. Natural killer cells go inside: entosis versus cannibalism. Cell Res 2009 Dec;19(12):1320-1. doi: 10.1038/cr.2009.134.
  118. Xu G, Zhang Y, Zhang L, Ren G, Shi Y*. Bone marrow stromal cells induce apoptosis of lymphoma cells in the presence of IFNgamma and TNF by producing nitric oxide. Biochem Biophys Res Commun 2008 Oct 31;375(4):666-70. doi: 10.1016/j.bbrc.2008.08.077.
  119. Ren GW, Su JJ, Zhao X, Zhang LY, Zhang JM, Roberts AI, Zhang HT, Das G, Shi Y*. Apoptotic cells induce immunosuppression through dendritic cells: critical roles of IFN-gamma and nitric oxide. J Immunol 2008 Sep 1;181(5):3277-84. doi: 10.4049/jimmunol.181.5.3277.
  120. Zhao RC, Zhu YS, Shi Y*. New Hope for Cancer Treatment: exploring the distinction between normal adult stem cells and cancer stem cells. Pharmacol Ther 2008 Jul;119(1):74-82. doi: 10.1016/j.pharmthera.2008.04.008.
  121. Zhang YY, Xu GW, Zhang LY, Roberts AI, Shi Y*. Th17 Cells Undergo Fas-mediated Activation-induced Cell Independent of IFN-γ. J Immunol 2008 Jul 1;181(1):190-6. doi: 10.4049/jimmunol.181.1.190.
  122. Yuan ZR and Shi Y*. Chloramphenicol induces abnormal differentiation and inhibits apoptosis in activated T cells. Cancer Res 2008 Jun 15;68(12):4875-81. doi: 10.1158/0008-5472.CAN-07-6061.
  123. Zhang J, Jiang H, Gao W, Wu J, Peng K, Shi Y, Zhang X. The JNK/AP1/ATF2 pathway is involved in H2O2-induced acetylcholinesterase expression during apoptosis. Cell Mol Life Sci 2008 May;65(9):1435-45. doi: 10.1007/s00018-008-8047-9.
  124. Shi Y* and August DA. A New Trick for an Old Drug: mTOR Inhibitor Rapamycin Augments the Effect of Fluorouracil on Hepatocellular Carcinoma through Inducing Cell Senescence. Cancer Biol Ther 2008 Mar;7(3):397-8. doi: 10.4161/cbt.7.3.5871.
  125. Ren GW, Zhang LY, Zhao X, Xu GW, Zhang YY, Roberts AI, Zhao RC, Shi Y*. Mesenchymal Stem Cell-Mediated Immunosuppression Occurs via Concerted Action of Chemokines and Nitric Oxide. Cell Stem Cell 2008 Feb 7;2(2):141-50. doi: 10.1016/j.stem.2007.11.014.
  126. Zhu H, Gao W, Jiang H, Jin QH, Shi Y, Tsim KW, Zhang XJ. Regulation of acetylcholinesterase expression by calcium signaling during calcium ionophore A23187- and thapsigargin-induced apoptosis. Int J Biochem Cell Biol 2007;39(1):93-108. doi: 10.1016/j.biocel.2006.06.012.
  127. Zhu H, Gao W, Shi Y, Zhang XJ. The CCAAT-binding factor CBF/NF-Y regulates the human acetylcholinesterase promoter activity during calcium ionophore A23187-induced cell apoptosis. Biochim Biophys Acta 2007 Oct;1770(10):1475-82. doi: 10.1016/j.bbagen.2007.07.007.
  128. Chen L, Zhang W, Yue H, Han Q, Chen B, Shi M, Li J, Li B, You S, Shi Y, Zhao RC. Effects of human mesenchymal stem cells on the differentiation of dendritic cells from CD34+ cells. Stem Cells Dev 2007 Oct;16(5):719-31. doi: 10.1089/scd.2007.0065.
  129. Xu G, Zhang Y, Zhang L, Ren G, Shi Y*. The role of IL-6 in inhibition of lymphocyte apoptosis by mesenchymal stem cells. Biochem Biophys Res Commun 2007 Sep 28;361(3):745-50. doi: 10.1016/j.bbrc.2007.07.052.
  130. Wang K, Desai B, Shi Y and Denhardt DT*. Osteopontin regulates hindlimb-unloading-induced lymphoid organ atrophy through modulating corticosteroid production. Proc Natl Acad Sci U S A 2007 Sep 11;104(37):14777-82. doi: 10.1073/pnas.0703236104.
  131. Ehirchiou D, Amarnath S, Xiong Y, Xu G, Chen W, Shi Y and Zhang L. CD11b Facilitates the Development of Peripheral Tolerance by Suppressing Th17 Differentiation. J Exp Med 2007 Jul 9;204(7):1519-24. doi: 10.1084/jem.20062292.
  132. Xu G and Shi Y*. Apoptosis signaling pathways and lymphocyte homeostasis. Cell Res 2007 Sep;17(9):759-71. doi: 10.1038/cr.2007.52.
  133. Zhu H, Gao W, Jiang H, Wu J, Shi Y, Zhang X. Calcineurin mediates acetylcholinesterase expression during calcium ionophore A23187-induced HeLa cell apoptosis. Biochim Biophys Acta 2007 Apr;1773(4):593-602. doi: 10.1016/j.bbamcr.2007.01.008.
  134. Xu G, Zhang L, Ren G, Yuan Z, Zhang Y, Zhao R, Shi Y*. Immunosuppressive properties of cloned bone marrow mesenchymal stem cells. Cell Res 2007 Mar;17(3):240-8. doi: 10.1038/cr.2007.4
  135. Das J, Eynott P, Van Kaer L, Shi Y* and Das G. Natural killer T cells and CD8+ T cells are dispensable for T cell-dependent allergic airway inflammation. Nat Med 2006 Dec;12(12):1345-6. doi: 10.1038/nm1206-1345.
  136. Das G*, Mittal J, Zhang Y, Bothwell A, Van Kare Luc, and Shi Y*. Pivotal Roles of Major Histocompatibility Complex Class Ib Restricted CD8+ T Cells in Autoimmune Diseases. J Exp Med 2006 Nov 27;203(12):2603-11. doi: 10.1084/jem.20060936.
  137. Devadas S, Das J, Liu C, Zhang L, Roberts AI, Pan Z, Moore PA, Das G, Shi Y*. Granzyme B is critical for T cell receptor-induced cell death of Type 2 helper T cells. Immunity 2006 Aug;25(2):237-47. doi: 10.1016/j.immuni.2006.06.011.
  138. Shi Y, Roberts AI, Sun E. Dying T lymphocytes call for the death of tumor cells. Commentary. Cell Res 2006 Aug;16(8):679-80. doi: 10.1038/sj.cr.7310087.
  139. Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G, Mukherjee C, Shi Y, Gelinas C, Fan Y, Nelson DA, Jin S, White E. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 2006 Jul;10(1):51-64. doi: 10.1016/j.ccr.2006.06.001
  140. Devadas S, Liu C, Shi Y. Novel helper T cell subset helps other T cells through producing GM-CSF. The Journal of Immunology 2006;176:S14-S15.
  141. Shi Y, Liu CH, Roberts AI, Das J, Xu G, Ren G, Zhang Y, Zhang L, Yuan ZR, Tan HS, Das G, Devadas S. Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) and T-Cell Responses: What We Do and Don′t Know. Cell Res 2006 Feb;16(2):126-33. doi: 10.1038/sj.cr.7310017.
  142. Yuan ZR, Wang R, Solomon J, Luo X, Sun H, Zhang L, Shi Y. Identification and characterization of survival-related gene, a novel cell survival gene controlling apoptosis and tumorigenesis. Cancer Res 2005 Dec 1;65(23):10716-24. doi:10.1158/0008-5472.CAN-05-2176.
  143. Greeneltch KM, Kelly-Welch AE, Keegan AD*,Shi Y*. Chronic morphine treatment promotes specific Th2 cytokine production by murine T cells in vitro via a Fas/Fas ligand-dependent mechanism. J Immunol 2005 Oct 15;175(8):4999-5005. doi: 10.4049/jimmunol.175.8.4999.
  144. Sun E, Zhang L, Roberts AI, Liu C and Shi Y. Chronic stress induced death of lymphocytes. Cytokines: Stress and Immunity Second Edition, edited by Nicholas P Plotnikoff, Robert E Faith, Anthony J Murgo, and Robert A Good. 2005, CRC Press.
  145. Greeneltch KM, Haudenschild CC, Keegan AD, Shi Y*. The opioid antagonist naltrexone blocks acute endotoxic shock by inhibiting tumor necrosis factor-alpha production. Brain Behav Immun 2004 Sep;18(5):476-84. doi: 10.1016/j.bbi.2003.12.001.
  146. Sun E, Gao Y, Chen J, Roberts AI, Wang X, Chen Z, Shi Y*. Allograft tolerance induced by donor apoptotic lymphocytes requires phagocytosis in the recipient. Cell Death Differ 2004 Dec;11(12):1258-64. doi: 10.1038/sj.cdd.4401500.
  147. Jin QH, He HY, Shi Y, Lu H, Zhang XJ. Overexpression of acetylcholinesterase inhibited cell proliferation and promoted apoptosis in NRK cells. Acta Pharmacol Sin 2004 Aug;25(8):1013-21.
  148. Pestka S, Krause CD, Sarkar D, Walter MR, Shi Y, Fisher PB. Interleukin-10 and related cytokines and receptors. Ann Rev Immunol 2004;22:929-79. doi: 10.1146/annurev.immunol.22.012703.104622.
  149. Roberts AI, Devadas S, Zhang X, Zhang L, Keegan A, Greeneltch K, Solomon J, Wei L, Das J, Sun E, Liu C, Yuan Z, Zhou JN, Shi Y*. The role of activation-induced cell death in the differentiation of T-helper-cell subsets. Immunologic Res 2003;28(3):285-93. doi: 10.1385/IR:28:3:285.
  150. Wei LX, Zhou JN, Roberts AI, Shi Y*. Lymphocyte reduction induced by hindlimb unloading: distinct mechanisms in the spleen and thymus. Cell Res 2003 Dec;13(6):465-71. doi: 10.1038/sj.cr.7290189.
  151. Shi Y*, Devadas S, Greeneltch KM, Yin D, Allan Mufson R, Zhou JN. Stressed to death: Implication of lymphocyte apoptosis for psychoneuroimmunology. Brain Behav Immun 2003 Feb;17 Suppl 1:S18-26.doi: 10.1016/s0889-1591(02)00062-4.
  152. Sun E and Shi Y. The mechanisms and significance of immune tolerance induced by apoptotic cells. In Shi YF, Cidlowski J, Scott DW and Shi YB. (Eds.). Molecular Mechanisms of Programmed Cell Death. Kluwer Academic/Plenum Publishers, New York 2003.
  153. Shi Y, Devadas S, Zhang X, Zhang L, Keegan AD, Greeneltch K, Solomon JC, Yuan Z, Sun E, Liu C, Das J, Thayyil-Satish M, Wei L, Zhou J and Roberts AI. Activation-Induced Cell Death and T Helper Subset Differentiation. Shi YF, Cidlowski J, Scott DW and Shi YB. (Eds.) Molecular Mechanisms of Programmmed Cell Death. Kluwer Academic/Plenum Publishers, New York 2003.
  154. Solomon JC, Sharma K, Wei LX, Fujita T, Shi Y*. A novel role for sphingolipid intermediates in activation-induced cell death in T cells. Cell Death Differ 2003 Feb;10(2):193-202. doi: 10.1038/sj.cdd.4401136.
  155. Zhang XR, Zhang LY, Devadas S, Li L, Keegan AD, Shi Y*. Reciprocal expression of TRAIL and CD95L in Th1 and Th2 cells: role of apoptosis in T helper subset differentiation. Cell Death Differ 2003 Feb;10(2):203-10. doi: 10.1038/sj.cdd.4401138.
  156. Jin QH, Shi Y, He HY, Ng KK, Jiang H, Yang L, Jiang ZQ, Zhang XJ*. Isolation of acetylcholinesterase from apoptotic human lung fibroblast cells by antibody affinity chromatography. Biotechniques 2002 Oct;Suppl:92-4, 96-7.
  157. Wang RX*, Shi Y*. A simplified protocol for apoptosis assay by DNA content analysis. Biotechniques 2002 Oct;Suppl:88-91.
  158. Tonon G, Luo X, Greco NJ, Chen W, Shi Y, GA. Weak platelet agonists and U46619 induce apoptosis-like events in platelets, in the absence of phosphatidylserine exposure. Thromb Res 2002 Sep 15;107(6):345-50.
  159. Zhang XJ, Yang L, Zhao Q, Caen JP, He HY, Jin QH, Guo LH, Alemany M, Zhang LY, Shi Y*. Induction of acetylcholinesterase expression during apoptosis in various cell types. Cell Death Differ 2002 Aug;9(8):790-800. doi: 10.1038/sj.cdd.4401034.
  160. Li L, Qi X, Williams M, Shi Y, Keegan AD. Overexpression of insulin receptor substrate-1, but not insulin receptor substrate-2, protects a T cell hybridoma from activation- induced cell death. J Immunol 2002 Jun 15;168(12):6215-23. doi: 10.4049/jimmunol.168.12.6215.
  161. Wang R, Zhang L, Zhang X, Moreno J, Celluzzi C, Tondravi M, Shi Y*. Regulation of activation-induced receptor activator of NF-kappaB ligand (RANKL) expression in T cells. Eur J Immunol 2002 Apr;32(4):1090-8. doi: 10.1002/1521-4141(200204)32:4<1090::AID-IMMU1090>3.0.CO;2-P.
  162. Gao Y, Shuang W, Shi Y, Sun E. Permanent liver allograft survival induced by transfusion of apoptotic donor splenocyte without immunosuppression. Cell Res 2002, 12:272-273.
  163. Sun EW*, Shi Y*. Apoptosis: the quiet death silences the immune system. Pharmacol Ther 2001 Nov-Dec;92(2-3):135-45. doi: 10.1016/s0163-7258(01)00164-4.
  164. Gubina E, Luo X, Kwon E, Sakamoto K, Shi Y, Mufson RA. Betac cytokine receptor-induced stimulation of cAMP response element binding protein phosphorylation requires protein kinase C in myeloid cells: a novel cytokine signal transduction cascade. J Immunol 2001 Oct 15;167(8):4303-10. doi: 10.4049/jimmunol.167.8.4303.
  165. Wang R, Zhang L, Zhang X, Moreno J, Luo X, Tondravi M, Shi Y*. Differential regulation of the expression of CD95 ligand, receptor activator of nuclear factor-kappa B ligand (RANKL), TNF-related apoptosis-inducing ligand (TRAIL), and TNF-alpha during T cell activation. J Immunol 2001 Feb 1;166(3):1983-90. doi: 10.4049/jimmunol.166.3.1983.
  166. Sharma K, Wang RX, Zhang LY, Yin DL, Luo XY, Solomon JC, Jiang RF, Markos K, Davidson W, Scott DW and Shi Y*. Death the Fas way: regulation and pathophysiology of CD95 and its ligand. Pharmacol Ther 2000 Dec;88(3):333-47. doi: 10.1016/s0163-7258(00)00096-6 .
  167. Yin D, Tuthill D, Mufson RA, Shi Y*. Chronic restraint stress promotes lymphocyte apoptosis by modulating CD95 expression. J Exp Med 2000 Apr 17;191(8):1423-8. doi: 10.1084/jem.191.8.1423.
  168. Yin D, Zhang L, Wang R, Radvanyi L, Haudenschild C, Fang Q, Kehry MR, Shi Y*. Ligation of CD28 in vivo induces CD40 ligand expression and promotes B cell survival.J Immunol 1999 Oct 15;163(8):4328-34.
  169. Sharma K*, Shi Y*. The yins and yangs of ceramide. Cell Res 1999 Mar;9(1):1-10. doi: 10.1038/sj.cr.7290001.
  170. Yin D, Mufson RA, Wang R, Shi Y*. Fas-mediated cell death promoted by opioids. Nature 1999 Jan 21;397(6716):218. doi: 10.1038/16612
  171. Wang R, Zhang L, Yin D, Mufson RA, Shi Y. Regulation of Fas and FasL expression during activation-induced T-cell apoptosis. In Talwar GP, Nath I, Ganguly NK and Rao KVS. (Eds.) Proceedings of 10th International Congress of Immunology Monduzzi Editore, Bologna, Italy 1999, pp 499-505
  172. Su Y, Damjanovski S, Shi Y, Shi YB. Molecular and cellular basis of tissue remodeling during amphibian metamorphosis. Histol Histopathol 1999 Jan;14(1):175-83. doi: 10.14670/HH-14.175.
  173. Wang R, Brunner T, Zhang L, Shi Y*. Fungal metabolite FR901228 inhibits c-Myc and Fas ligand expression. Oncogene 1998 Sep 24;17(12):1503-8. doi: 10.1038/sj.onc.1202059.
  174. Wang R, Zhang L, Yin D, Mufson RA, Shi Y*. Protein kinase C regulates Fas (CD95/APO-1) expression. J Immunol 1998 Sep 1;161(5):2201-7.
  175. Zamorano J, Wang HY, Wang R, Shi Y*, Longmore GD and Keegan AD*. Regulation of cell growth by IL-2: role of STAT5 in protection from apoptosis but not in cell cycle progression. J Immunol 1998 Apr 1;160(7):3502-12.
  176. Su Y, Shi Y, Stolow MA, Shi YB. Thyroid hormone induces apoptosis in primary cell cultures of tadpole intestine: cell type specificity and effects of extracellular matrix. J Cell Biol 1997 Dec 15;139(6):1533-43. doi: 10.1083/jcb.139.6.1533.
  177. Shi YF, Wang R, Sharma A, Gao C, Collins M, Penn L, Mills GB. Dissociation of cytokine signals for proliferation and apoptosis. J Immunol 1997 Dec 1;159(11):5318-28.
  178. Liang FT, Granstrom DE, Timoney JF, Shi YF*. Micropreparative high resolution purification of proteins by a combination of sodium dodecyl sulfate-polyacrylamide gel electrophoresis, isoelectric focusing, and membrane blotting. Anal Biochem 1997 Jul 15;250(1):61-5. doi: 10.1006/abio.1997.2196.
  179. Shi Y, Mills GB and Wang R. Mitogenic Cytokines Promote Apoptosis: Possible Roles in Cellular Homeostasis. In Shi YB, Shi YF, Scott DW and Xu YH. (Eds.) Current Advances in Programmed Cell Death Plenum Publishing Corp., New York 1997, pp 113-142.
  180. Shi Y, Hill M, Novak A, Chen ZQ, Wang RX, Liew CC, Mills GB. Human hematopoietic cell express two forms of the cytokine receptor common gamma-chain (gamma c). Cell Res 1997 Dec;7(2):195-205. doi: 10.1038/cr.1997.20.
  181. Su Y#, Shi Y#, Shi YB. Cyclosporin A but not FK506 inhibits thyroid hormone-induced apoptosis in tadpole intestinal epithelium. Faseb J 1997 Jun;11(7):559-65. doi: 10.1096/fasebj.11.7.9212079.
  182. Wang R, Fang Q, Zhang L, Radvany L, Sharma A, Noben-Trauth N, Mills GB, Shi Y*. CD28 ligation prevents bacterial toxin-induced septic shock in mice by inducing IL-10 expression. J Immunol 1997 Mar 15;158(6):2856-61.
  183. Liang T, Granstrom DE, Shi Y*. Concentrating protein samples for sodium dodecyl sulphate-polyacrylamide gel electrophoresis and isoelectric focusing using protein-blotting membranes. J Chromatogr A 1997 Mar 7;764(1):143-50. doi: 10.1016/s0021-9673(96)00848-5.
  184. Scott DW, Brunner T, Donjerkovic D, Ezhevsky S, Grdina T, Green DR, Shi Y, Yao X. Murder and suicide: A tale of T and B cell apoptosis. In Shi YB, Shi YF, Scott DW and Xu YH. (Eds.) Current Advances in Programmed Cell Death Plenum Publishing Corp., New York 1997, pp 91-103.
  185. Radvanyi LG, Shi Y, Mills GB, Miller RG. Cell cycle progression out of G1 sensitizes primary-cultured nontransformed T cells to TCR-mediated apoptosis. Cell Immunol 1996 Jun 15;170(2):260-73. doi: 10.1006/cimm.1996.0160.
  186. Scott DW, Grdina T, Shi Y*. T cells commit suicide, but B cells are murdered! J Immunol 1996 Apr 1;156(7):2352-6.
  187. Radvanyi LG, Shi Y, Vaziri H, Sharma A, Dhala R, Mills GB, Miller RG. CD28 costimulation inhibits TCR-induced apoptosis during a primary T cell response. J Immunol 1996 Mar 1;156(5):1788-98.
  188. Shi Y and Wang R. Apoptosis and immune regulation. In Li C, Guo Y, Yie Q and Tang X. (Eds.) Current Advance in Tumor Molecular Biology Medical Science Publisher, Beijing 1996, pp 61-69.
  189. Scott DW, Ezhevksy S, Maddox B, Washart K, Yao X, Shi Y. Scenes from short life: checkpoints and progression signals for immature B-cell life versus apoptosis. In Rigley K, and Harnett M. (Eds.). John Wiley, Chichester, England 1995, pp 165-175.
  190. McGahon AJ, Martin SJ, Bissonnette RP, Mahboubi A, Shi Y, Mogil RJ, Nishioka WK, Green DR. The end of the (cell) line: methods for the study of apoptosis in vitro. Methods Cell Biol 1995;46:153-85.
  191. Shi Y, Radvanyi LG, Sharma A, Shaw P, Green DR, Miller RG and Mills GB. CD28-mediated signaling in vivo prevents activation-induced apoptosis in the thymus and alters peripheral lymphocyte homeostasis. J Immunol 1995 Aug 15;155(4):1829-37.
  192. Shi Y, Frankel A, Radvanyi LG, Penn LZ, Miller RG, Mills GB. Rapamycin enhances apoptosis and increases sensitivity to cisplatin in vitro. Cancer Res 1995 May 1;55(9):1982-8.
  193. Green DR, Mahboubi A, Nishioka W, Oja S, Echeverri F, Shi Y, Glynn J, Yang Y, Ashwell J and Bissonnette R. Promotion and inhibition of activation-induced apoptosis in T-cell hybridomas by oncogenes and related signals. Immunol Rev 1994 Dec;142:321-42.doi: 10.1111/j.1600-065x.1994.tb00895.x.
  194. Rabinovitch A, Suarez-Pinzon WL, Shi Y, Morgan AR, Bleackley RC. DNA fragmentation is an early event in cytokine-induced islet beta-cell destruction. Diabetologia 1994 Aug;37(8):733-8. doi: 10.1007/bf00404328.
  195. Bissonnette RP, Shi Y, Mahboubi A, Glynn JM and Green DR. C-myc and apoptosis. In Tomei LD and Cope FO. (Eds.) Apoptosis II: The Molecular Basis of Cell Death Cold Spring Harbor Lab Press, Cold Spring Harbor, New York 1994, pp 327-335.
  196. Mogil RJ, Shi Y, Bissonnette RP, Bromley P, Yamaguchi I, Green DR. Role of DNA fragmentation in T cell activation-induced apoptosis in vitro and in vivo. J Immunol 1994 Feb 15;152(4):1674-83.
  197. Green DR, Shi Y, Glynn JM, Mahboubi A and Mogil RJ. Myc, Fas, apoptosis, and immune tolerance. In: Apoptosis. In Mihich E and Schimke RT. (Eds.) Apoptosis Plenum Press, New York 1994, pp 213-222
  198. Bissonnette RP, Shi Y, Mahboubi A, Glynn JM. C-myc and apoptosis. Current Communications in Cell and Molecular Biology 1994, 327-327
  199. Mills GB, Schmandt R, Gibson S, Leung B, Hill M, May C, Shi Y, Branch DR, Radvanyi L, Truitt KE and et al. Transmembrane signaling by the interleukin-2 receptor: progress and conundrums. Semin Immunol 1993 Oct;5(5):345-64. doi: 10.1006/smim.1993.1041.
  200. Shi Y, Kornovski BS, Savani R Turley EA. A rapid, multiwell colorimetric assay for chemotaxis. J Immunol Methods 1993 Sep 15;164(2):149-54. doi: 10.1016/0022-1759(93)90307-s.
  201. Helgason CD, Shi L, Greenberg AH, Shi Y, Bromley P, Cotter TG, Green DR and Bleackley RC. DNA fragmentation induced by cytotoxic T lymphocytes can result in target cell death. Exp Cell Res 1993 Jun;206(2):302-10. doi: 10.1006/excr.1993.1150.
  202. Green DR, Bissonnette RP, Glynn JM and Shi Y. Activation-induced apoptosis in lymphoid systems. Semin Immunol 1992 Dec;4(6):379-88.
  203. Green DR, Zheng H and Shi Y*. Antisense oligodeoxynucleotides as probes of T-lymphocyte gene function. Ann N Y Acad Sci 1992 Oct 28;660:193-203. doi: 10.1111/j.1749-6632.1992.tb21071.x.
  204. Shi Y, Glynn JM, Guilbert LJ, Cotter TG, Bissonnette RP and Green DR. Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas. Science 1992 Jul 10;257(5067):212-4. doi: 10.1126/science.1378649 (with cover illustration).
  205. Shi Y, Bissonnette RP, Parfrey N, Szalay M, Kubo RT and Green DR. In vivo administration of monoclonal antibodies to the CD3 T cell receptor complex induces cell death (apoptosis) in immature thymocytes. J Immunol 1991 May 15;146(10):3340-6.
  206. Green DR and Shi Y. Activation-induced cell death in developing T cells and T cell hybridomas. In Malhotra SK. (Ed.) Advances in Structural Biology JAI Press, Inc. 1990, pp 287-299.
  207. Shi Y, Szalay MG, Paskar L, Sahai BM, Boyer M, Singh B and Green DR. Activation-induced cell death in T cell hybridomas is due to apoptosis. Morphologic aspects and DNA fragmentation. J Immunol 1990 May 1;144(9):3326-33.
  208. Shi Y, Sahai BM and Green DR. Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes. Nature 1989 Jun 22;339(6226):625-6. doi: 10.1038/339625a0.
  209. Shi Y, Mahrt JL and Mogil RJ. Kinetics of murine delayed-type hypersensitivity response to Eimeria falciformis (Apicomplexa: Eimeriidae). Infect Immun 1989 Jan;57(1):146-51.
  210. Mahrt JL and Shi Y. Murine major histocompatibility complex and immune response to Eimeria falciformis. Infect Immun 1988 Jan;56(1):270-1.