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ZHOU Zhangsen


Professor, Principal Investigator

Laboratory of Organelle Communication and Metabolic Diseases

Email: zszhou@sibs.ac.cn

Tel: 86-21-54920098

Research Areas

Organelles within a cell communicate with each other to exchange information and maintain cellular homeostasis. Indeed, various diseases such as obesity and type-2 diabetes are linked to dysregulation of organelle communication. Membrane contact sites mediate organelle communication and are key to organelle homeostasis and organismal health. Mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs), characterized by intimate contact between the ER and mitochondria, are indispensable for mitochondrial DNA synthesis and fission, as well as calcium exchange and lipid biosynthesis. Using high-throughput screening, proteomics and 3D reconstruction, our lab will investigate the molecular mechanisms of ER-mitochondria communication and its physiological role in health and diseases, and provide new potential therapeutic targets for the treatment of metabolic diseases.


Brief Biography

2021-Present: Professor, Principal Investigator, Shanghai Institute of Nutrition and Health, CAS, Shanghai, China

2016-2021: Postdoctoral Fellow, University of Michigan, Ann Arbor, MI, USA

2015-2016: Assistant Research Fellow,Wuhan University, Wuhan, Hubei, China

2009-2015: Ph.D., Shanghai Institute of Biochemistry and Cell Biology, CAS, Shanghai, China

2004-2008: B.S., Shandong University, Jinan, Shandong, China


Selected Publications (#Co-first Author, *Corresponding Author)

  1. Yoshida S, Wei X, Zhang G, O'Connor CL, Torres M, Zhou Z, Lin L, Menon R, Xu X, Zheng W, Xiong Y, Otto E, Tang CA, Hua R, Verma R, Mori H, Zhang Y, Hu CA, Liu M, Garg P, Hodgin JB, Sun S, Bitzer M, Qi L* (2021) Endoplasmic reticulum-associated degradation is required for nephrin maturation and kidney glomerular filtration function. J Clin Invest 131(7):e143988.
  2. Zhou Z#, Torres M#, Sha H, Halbrook CJ, Van den Bergh F, Reinert RB, Yamada T, Wang S, Luo Y, Hunter AH, Wang C, Sanderson TH, Liu M, Taylor A, Sesaki H, Lyssiotis CA, Wu J, Kersten S, Beard DA, Qi L* (2020a) Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes. Science 368(6486):54-60.
  3. Zhou ZS#, Li MX#, Liu J#, Jiao H, Xia JM, Shi XJ, Zhao H, Chu L, Liu J, Qi W, Luo J, Song BL* (2020b) Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2. Nat Commun 11(1):379.
  4. Li N, Zhou ZS, Shen Y, Xu J, Miao HH, Xiong Y, Xu F, Li BL, Luo J, Song BL* (2017) Inhibition of the sterol regulatory element-binding protein pathway suppresses hepatocellular carcinoma by repressing inflammation in mice. Hepatology 65(6):1936-1947.
  5. Xie C#, Zhou ZS#, Li N, Bian Y, Wang YJ, Wang LJ, Li BL*, Song BL* (2012) Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine. J Lipid Res 53(10):2092-2101.