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ZHOU Ben

Ph.D.

Professor, Principal Investigator

Laboratory of Energy Homeostasis and Healthy Aging

Email: benzhou@sibs.ac.cn

Tel: 86-21-54920717

Research Areas:

Our major research interests are to use multiple model systems including C. elegans, mammalian cells and mice to investigate the underlying molecular mechanisms of energy homeostasis, aging and aging related diseases. Our goal is to use genetic and nutrition intervention approaches to promote healthy aging.

 

Brief Biography:

Education

2006-2012: Ph.D. Biochemistry and Molecular Biology, Institute for Nutritional Sciences, Chinese Academy of Science, Shanghai, China

2002-2006: B.S. Biochemistry, Nanjing University, Nanjing, China

Academic Background

2020-Present: Professor, Principal Investigator, Shanghai Institute of Nutrition and Health, CAS

2013-2019: Postdoctoral Research Fellow, Department of Medicine, Harvard Medical School/Center for Genetic Medicine, Massachusetts General Hospital, Boston, MA, USA

 

Selected Publications:

  1. Zhou B*, Zhang Y, Li S, Wu L, Fejes-Toth G, Naray-Fejes-Toth A, Soukas AA. Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase. Cell Reports 2021 Oct 5;37(1):109785.
  2. Wang F, Dai Y, Zhu X, Chen Q, Zhu H, Zhou B, Tang H, Pang S. Saturated very long chain fatty acid configures glycosphingolipid for lysosome homeostasis in long-lived C. elegans. Nature communications 2021 Aug 20;12(1):5073.
  3. Zhou B, Soukas AA. Suppressing the dark side of autophagy. Autophagy 2019 Oct;15(10):1852-1853.
  4. Soukas AA, Zhou B. Surviving Starvation Simply Without TFEB. PLoS Biology 2019 May 28;17(5):e3000285.
  5. Zhou B, Kreuzer J, Kumsta C, Wu L, Kamer KJ, Cedillo L, Zhang Y, Li S, Kacergis MC, Webster CM, Fejes-Toth G, Naray-Fejes-Toth A, Das S, Hansen M, Haas W, Soukas AA. Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension. Cell 2019 Apr 4;177(2):299-314.e16.
  6. Webster CM, Pino EC, Carr CE, Wu L, Zhou B, Cedillo L, Kacergis MC, Sea CP, Soukas AA. Genome-wide RNAi Screen for Fat Regulatory Genes in C. elegans Identifies a Proteostasis-AMPK Axis Critical for Starvation Survival. Cell Report 2017 Jul 18;20(3):627-640.
  7. Wu L, Zhou B, Oshiro-Rapley N, Li M, Paulo JA, Webster CM, Mou F, Kacergis MC, Talkowski ME, Carr CE, Gygi SP, Zheng B, Soukas AA. An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer. Cell 2016 Dec 15;167(7):1705-1718.e13.
  8. Liu J, Zhou B, Yan MH, Huang R, Wang YG, He ZS, Yang YG, Dai CG, Wang YQ, Zhang F, Zhai QW. CLOCK and BMAL1 regulate muscle insulin sensitivity via SIRT1 in male mice. Endocrinology 2016 Jun;157(6):2259-2269.
  9. Zhou B#, Zhang Y#, Zhang F#, Xia YL, Liu J, Huang R, Wang YG, Hu YN, Wu JX, Dai CG, Wang H, Tu YY, Peng XZ, Wang YQ, Zhai QW. CLOCK/BMAL1 regulates circadian change of insuin sensitivity via SIRT1. Hepatology 2014 Jun;59(6):2196-2206. (# equal contribution)
  10. Zhang Y#, Zhou B#, Deng B, Zhang F, Wu JX, Wang YG, Le YY, Zhai QW. Amyloid-β induces hepatic insulin resistance in vivo via JAK2. Diabetes 2013 Apr;62(4):1159-1166. (# equal contribution)
  11. Wei HB#, Zhou B#, Zhang F, Tu YY, Zhang BG, Zhai QW. Profiling and identification of small rDNA-derived RNAs and their potential biological functions. PLoS One 2013 Feb;8(2):e56842. (# equal contribution)
  12. Zhou B#, Li C#, Qi W, Zhang Y, Zhang F, Wu JX, Hu YN, Wu DM, Liu Y, Yan TT, Jing Q, Liu MF, Zhai QW. Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity. Diabetologia 2012 Jul;55(7):2032-2043. (# equal contribution)
  13. Zhang Y, Zhou B, Zhang F, Wu JX, Hu YN, Liu Y, Zhai QW. Amyloid-β induces insulin resistance by activating JAK2/STAT3/SOCS-1 signalling pathway. Diabetes 2012 Jun;61(6):1434-1443.