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ZHOU Yong

Ph.D.

Professor, Principal Investigator

Laboratory of Development and Disease

Email: zhouyong@sibs.ac.cn

Tel: 86-21-54923289

Research Areas: 

1. Signal regulation and reprogramming mechanisms of cardiac progenitors;

2. Molecular mechanisms of normal haematopoietic and malignant transformation, including epigenetics, key node genes and immune microenvironment analysis 

 

Brief Biography: 

2017-Present: Professor, Principal Investigator, Shanghai Institute of Nutrition and Health, CAS 

2011-2016: Professor, Principal Investigator, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine 

2008-2011: Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, USA), Postdoc Research fellow 

2006-2008: Ottawa Health Research Institute, Ottawa Hospital, University of Ottawa, Ottawa, Canada, Postdoc Research fellow 

2001-2006: Key laboratory of Marine Drugs, Ministry of Education, P.R. China, Institute of Marine Drugs, Ocean university of China, Qingdao, Pharmacology (Ph.D.) 

2002-2006: Institute of Matria Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, Pharmacology (Ph.D. joint program) 

1997-2001: Ocean university of China, Qingdao, China. Pharmaceutical Chemistry (M.D.) 

 

Selected Publications: (*Corresponding Author)

  1. Hui-Min Yin, Li-Feng Yan, Qian Liu, Zheng Peng, Chi-Yuan Zhang, Yu Xia, Dan Su, Ai-Hua Gu*, Yong Zhou*. Activating transcription factor 3 coordinates differentiation of cardiac and hematopoietic progenitors by regulating glucose metabolism. Science Advances, 2020 May 6;6(19):eaay9466
  2. Chu LM, Yin HM, Gao L, Xia Yu, Zhang CY, Chen Y, Liu TX, Huang JJ, Boheler KR, Zhou Y*, Yang HT*. Cardiac Na+-Ca2+ exchanger 1 (ncx1h) is critical for the ventricular cardiomyocyte formation via regulating the expression levels of gata4 and hand2 in zebrafish. Science China Life Science, 2020 Jul 7;doi:10.1007/s11427-019-1706-1
  3. Yangyang Xie, Li Gao, Chunhui Xu, Liming Chu, Lei Gao, Ruichi Wu, Yu Liu, Ting Liu, Xiao-Jian Sun, Ruibao Ren, Jingyan Tang, Yi Zheng*, Yong Zhou*, Shuhong Shen*. ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients. Haematologica, 2020 Apr;105(4):925-936
  4. Zhang Chiyuan, Yin Huimin, Wang He, Su Dan, Xia Yu, Yan Lifeng, Fang Bin, Liu Wei, Wang Yumei, Gu Aihua*, Zhou Yong*. Transforming growth factor-β1 regulates the nascent hematopoietic stem cell niche by promoting gluconeogenesis. Leukemia, 2018 Feb;32(2):479-491
  5. Meng Zhao-Zheng, Liu Wei, Xia Yu, Yin Hui-Min, Zhang Chi-Yuan, Dan Su, Yan Li-Feng, Gu Ai-Hua*, Zhou Yong*. The pro-inflammatorysignalling regulator Stat4 promotes vasculogenesis of great vessels derivedfrom endothelial precursors. Nature Communications, 2017 Mar 3;8:14640
  6. X Peng, M Dong, L Ma, X-E Jia, J Mao, C Jin, Y Chen, L Gao, X Liu, K Ma, L Wang, T Du, Y Jin, Q Huang, K Li, LI Zon, T Liu, M Deng*, Y Zhou*, X Xi, Y Zhou*, S Chen*. A point mutation of zebrafish c-cbl gene in the ring finger domain produces a phenotype mimicking human myeloproliferative disease. Leukemia, 2015 Jan 1;29:2355-2365
  7. Fan Hongbo, Liu Yijie, Wang Lei, Du Tingting, Gao Li, Meng Zhaozheng, Jin Yi, Chen Yi, Deng Min, Yang Huangtian, Jing Qing, Gu Aihua*, Zhou Yong*. miR-142-3p acts as an essential modulator of neutrophil development in zebrafish. Blood, 2014 Aug 21;124(8):1320-1330
  8. Dong Zhiwei, Ren Chunguang, Su Dan, Du Tingting, Fan Hongbo, Yuan Hao, Wang Lei, Dong Mei, Li Weichun, Jin Yi, Chen Yi, Deng Min, Liu Tingxi, Gu Aihua*, Zhou Yong*. Pten regulates homeostasis and inflammation-induced migration of myelocytes in zebrafish. Journal of Hematology & Oncology, 2014 Mar 5;7(1):17-30
  9. Wang Lei, Fu Cong, Fan Hongbo, Du Tingting, Dong Mei, Chen Yi, Jin Yi, Zhou Yi, Deng Min, Gu Aihua*, Jing Qing* Liu Tingxi, Zhou Yong*. miR-34b regulates multiciliogenesis during organ formation in zebrafish. Development, 2013 Jul 1;140(13):2755-2764
  10. Gu Aihua*, Ji Guixiang, Yan Lifeng, Zhou Yong*. The 8-oxoguanine DNA glycosylase 1 (ogg1) decreases the vulnerability of the developing brain to DNA damage. DNA Repair, 2013 Dec 1;12(12):1094-1104
  11. Jing Changbin, Chen Yi, Dong Mei, Peng Xiaolan, Jia Xiaoe, Gao Lei, Ma Ke, Deng Min, Liu Tingxi, Zon LI, Zhu Jun*, Zhou Yi, Zhou Yong*, Liu Yijie. Phospholipase C gamma-1 is required for granulocyte maturation in zebrafish. Developmental Biology, 2013 Feb 1;374(1):24-31
  12. Yan L#, Zhou Y#, Yu S, Ji G, Wang L, Liu W, Gu A. 8-Oxoguanine DNA glycosylase 1 (ogg1) maintains the function of cardiac progenitor cells during heart formation in zebrafish. Exp Cell Res, 2013;319(19):2954-2963
  13. Zhou Y#, Cashman TJ, Nevis K, Obregon P, Carney SA, Liu Y, Gu AH, Mosimann C, Sondalle S, Peterson R, Heideman W, Burns CE, Burns CG. Latent TGF-b binding protein 3 identifies a second heart field in zebrafish. Nature, 2011;474:645-648 (Highlighted)
  14. Deacon DC, Nevis KR, Cashman TJ, Zhou Y, Zhao L, Washko D, Guner-Ataman B, Burns CG, Burns CE. The miR-143-adducin3 pathway is essential for cardiac chamber morphogenesis. Development, 2010;137(11):1887-1896
  15. Zhou Y#, Ma C, Karmouch J, Katbi HA, Liu XJ. Antiapoptotic role for ornithine decarboxylase during oocyte maturation. Mol Cell Biol, 2009 Apr;29(7):1786-1795