Research Areas
1. Signal regulation and reprogramming mechanisms of cardiac progenitors
2. Molecular mechanisms of normal haematopoietic and malignant transformation, including epigenetics, key node genes and immune microenvironment analysis

Brief Biography
2017-Present: Professor, Principal Investigator, Shanghai Institute of Nutrition and Health, CAS
2011-2016: Professor, Principal Investigator, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine
2008-2011: Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, USA), Postdoc Research fellow
2006-2008: Ottawa Health Research Institute, Ottawa Hospital, University of Ottawa, Ottawa, Canada, Postdoc Research fellow
2001-2006: Key laboratory of Marine Drugs, Ministry of Education, P.R. China, Institute of Marine Drugs, Ocean university of China, Qingdao, Pharmacology (Ph.D.)
2002-2006: Institute of Matria Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, Pharmacology (Ph.D. joint program)
1997-2001: Ocean university of China, Qingdao, China. Pharmaceutical Chemistry (M.D.)

Selected Publications (*Corresponding Author)

1. Hui-Min Yin, Li-Feng Yan, Qian Liu, Zheng Peng, Chi-Yuan Zhang, Yu Xia, Dan Su, Ai-Hua Gu*, Yong Zhou*. Activating transcription factor 3 coordinates differentiation of cardiac and hematopoietic progenitors by regulating glucose metabolism. Science Advances 2020 May 6;6(19):eaay9466
2. Chu LM, Yin HM, Gao L, Xia Yu, Zhang CY, Chen Y, Liu TX, Huang JJ, Boheler KR, Zhou Y*, Yang HT*. Cardiac Na⁺-Ca²⁺ exchanger 1 (ncx1h) is critical for the ventricular cardiomyocyte formation via regulating the expression levels of gata4 and hand2 in zebrafish. Science China Life Science 2020 Jul 7;doi:10.1007/s11427-019-1706-1
3. Yangyang Xie, Li Gao, Chunhui Xu, Liming Chu, Lei Gao, Ruichi Wu, Yu Liu, Ting Liu, Xiao-Jian Sun, Ruibao Ren, Jingyan Tang, Yi Zheng*, Yong Zhou*, Shuhong Shen*. ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients. Haematologica 2020 Apr;105(4):925-936
4. Zhang Chiyuan, Yin Huimin, Wang He, Su Dan, Xia Yu, Yan Lifeng, Fang Bin, Liu Wei, Wang Yumei, Gu Aihua*, Zhou Yong*. Transforming growth factor-β1 regulates the nascent hematopoietic stem cell niche by promoting gluconeogenesis. Leukemia 2018 Feb;32(2):479-491
5. Meng Zhao-Zheng, Liu Wei, Xia Yu, Yin Hui-Min, Zhang Chi-Yuan, Dan Su, Yan Li-Feng, Gu Ai-Hua*, Zhou Yong*. The pro-inflammatorysignalling regulator Stat4 promotes vasculogenesis of great vessels derivedfrom endothelial precursors. Nature Communications 2017 Mar 3;8:14640
6. X Peng, M Dong, L Ma, X-E Jia, J Mao, C Jin, Y Chen, L Gao, X Liu, K Ma, L Wang, T Du, Y Jin, Q Huang, K Li, LI Zon, T Liu, M Deng*, Y Zhou*, X Xi, Y Zhou*, S Chen*. A point mutation of zebrafish c-cbl gene in the ring finger domain produces a phenotype mimicking human myeloproliferative disease. Leukemia 2015 Jan 1;29:2355-2365
7. Fan Hongbo, Liu Yijie, Wang Lei, Du Tingting, Gao Li, Meng Zhaozheng, Jin Yi, Chen Yi, Deng Min, Yang Huangtian, Jing Qing, Gu Aihua*, Zhou Yong*. miR-142-3p acts as an essential modulator of neutrophil development in zebrafish. Blood 2014 Aug 21;124(8):1320-1330
8. Dong Zhiwei, Ren Chunguang, Su Dan, Du Tingting, Fan Hongbo, Yuan Hao, Wang Lei, Dong Mei, Li Weichun, Jin Yi, Chen Yi, Deng Min, Liu Tingxi, Gu Aihua*, Zhou Yong*. Pten regulates homeostasis and inflammation-induced migration of myelocytes in zebrafish. Journal of Hematology & Oncology 2014 Mar 5;7(1):17-30
9. Wang Lei, Fu Cong, Fan Hongbo, Du Tingting, Dong Mei, Chen Yi, Jin Yi, Zhou Yi, Deng Min, Gu Aihua*, Jing Qing* Liu Tingxi, Zhou Yong*. miR-34b regulates multiciliogenesis during organ formation in zebrafish. Development 2013 Jul 1;140(13):2755-2764
10. Gu Aihua*, Ji Guixiang, Yan Lifeng, Zhou Yong*. The 8-oxoguanine DNA glycosylase 1 (ogg1) decreases the vulnerability of the developing brain to DNA damage. DNA Repair 2013 Dec 1;12(12):1094-1104
11. Jing Changbin, Chen Yi, Dong Mei, Peng Xiaolan, Jia Xiaoe, Gao Lei, Ma Ke, Deng Min, Liu Tingxi, Zon LI, Zhu Jun*, Zhou Yi, Zhou Yong*, Liu Yijie. Phospholipase C gamma-1 is required for granulocyte maturation in zebrafish. Developmental Biology 2013 Feb 1;374(1):24-31
12. Yan L^#, Zhou Y^#, Yu S, Ji G, Wang L, Liu W, Gu A. 8-Oxoguanine DNA glycosylase 1 (ogg1) maintains the function of cardiac progenitor cells during heart formation in zebrafish. Exp Cell Res 2013;319(19):2954-2963
13. Zhou Y^#, Cashman TJ, Nevis K, Obregon P, Carney SA, Liu Y, Gu AH, Mosimann C, Sondalle S, Peterson R, Heideman W, Burns CE, Burns CG. Latent TGF-b binding protein 3 identifies a second heart field in zebrafish. Nature 2011;474:645-648 (Highlighted)
14. Deacon DC, Nevis KR, Cashman TJ, Zhou Y, Zhao L, Washko D, Guner-Ataman B, Burns CG, Burns CE. The miR-143-adducin3 pathway is essential for cardiac chamber morphogenesis. Development 2010;137(11):1887-1896
15. Zhou Y^#, Ma C, Karmouch J, Katbi HA, Liu XJ. Antiapoptotic role for ornithine decarboxylase during oocyte maturation. Mol Cell Biol 2009 Apr;29(7):1786-1795