Research Areas:

Disruption of cell polarity is an important hallmark of cancer. The role polarity proteins play during tumorigenesis is poorly understood. Using cell culture studies and mouse tumor models, we will identify novel polarity pathways play in normal cell architecture and tissue morphogenesis. Through the molecular analysis of aberrant genetic and epigenetic pathways in epithelia cancer, we want to characterize the molecular basis of cell architecture during tumor initiation and identify potential diagnosis marker or drug targets.

Brief Biography:

Jan 2017 – present Professor, Principal Investigator, Shanghai Institute of Nutrition and Health (SINH), CAS

Feb 2010 – Dec 2016 Professor, Institute for Nutritional Sciences, SIBS, CAS

Nov 2004 – Feb 2010 Postdoctoral researcher, Cold Spring Harbor laboratory, New York, USA

Aug 1998 – Aug 2003 M.D., Second Military Medical University, Dept. of gastroenterology of changhai hospital, Shanghai, China

Aug 1991 – Jul 1996 Bachelor of Medicine, Zhejiang University School of Medicine.Hangzhou, Zhejiang, China

Selected Publications: (*Corresponding Author)

1. Chang R, Song L, Xu Y, Wu Y, Dai C, Wang X, Sun X, Hou Y, Li W, Zhan X, Zhan L. Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis. Nat Commun 2018 Aug 28;9(1):3486
2. Guo J, Xu Y, Ji W, Song L, Dai C, Zhan L. Effects of exposure to benzo[a]pyrene on metastasis of breast cancer are mediated through ROS-ERK-MMP9 axis signaling. Toxicol Lett 2015 May 5;234(3):201-210

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Research Areas: 

Disruption of cell polarity is an important hallmark of cancer. The role polarity proteins play during tumorigenesis is poorly understood. Using cell culture studies and mouse tumor models, we will identify novel polarity pathways play in normal cell architecture and tissue morphogenesis. Through the molecular analysis of aberrant genetic and epigenetic pathways in epithelia cancer, we want to characterize the molecular basis of cell architecture during tumor initiation and identify potential diagnosis marker or drug targets. 

 

Brief Biography: 

Jan 2017 – present:  Professor, Principal Investigator, Shanghai Institute of Nutrition and Health (SINH), CAS 

Feb 2010 – Dec 2016:  Professor, Institute for Nutritional Sciences, SIBS, CAS

Nov 2004 – Feb 2010:  Postdoctoral researcher, Cold Spring Harbor laboratory, New York, USA

Aug 1998 – Aug 2003:  M.D., Second Military Medical University, Dept. of gastroenterology of changhai hospital, Shanghai, China

Aug 1991 – Jul 1996:  Bachelor of Medicine, Zhejiang University School of Medicine.Hangzhou, Zhejiang, China

 

Selected Publications: (*Corresponding Author)

1．Chang,Renxu; Song,Lele; Xu,Yi; Wu,Yanjun; Dai,Cheng; Wang,Xinyu; Sun,Xia; Hou,Yingyong; Li,Wei; Zhan,Xiaobao; Zhan,Lixing^(*), Loss of Wwox drives metastasis 1 in triple-negative breast cancer by upregulating the IL6/JAK2/STAT3 axis, nature communications，accepted  

2．Li,Xiaojiao; Song,Lele; Hu,Xingjie; Liu,Chang; Shi,Jiye; Wang,Hui^(*); Zhan,Lixing^(*); Song,Haiyun^(*), Inhibition of Epithelial-Mesenchymal Transition and Tissue Regeneration by Waterborne Titanium Dioxide Nanoparticles, ACS Appl Mater Interfaces, 2018.1.10, 10(4): 3449~3458     

3．Zhou,Yi; Chang,Renxu; Ji,Weiwei; Wang,Na; Qi,Meiyan; Xu,Yi; Guo,Jingyu; Zhan,Lixing^(*), Loss of Scribble Promotes Snail Translation through Translocation of HuR and Enhances Cancer Drug Resistance, Journal of Biological Chemistry, 2016.1.1, 291(1): 291~302  

4．Xu,Yi; Chang,Renxu; Peng,Zhiyong; Wang,Yanmei; Ji,Weiwei; Guo,Jingyu; Song,Lele; Dai,Cheng; Wei,Wei; Wu,Yanjun; Wan,Xinjian; Shao,Chenghao; Zhan,Lixing^(*), Loss of polarity protein AF6 promotes pancreatic cancer metastasis by inducing Snail expression, Nature Communications, 2015.5, 6: 7184      

5．Song,Lele; Chang,Renxu; Dai,Cheng; Wu,Yanjun; Guo,Jingyu; Qi,Meiyan; Zhou,Wu^(*); Zhan,Lixing^(*), SORBS1 suppresses tumor metastasis and improves the sensitivity of cancerto chemotherapy drug, Oncotarget, 2016.10.24, 8(6): 9108~9122      

6．Guo,Jingyu; Xu,Yi; Ji,Weiwei; Song,Lele; Dai,Cheng; Zhan,Lixing^(*), Effects of exposure to benzo[a]pyrene on metastasis of breast cancer are mediated through ROS-ERK-MMP9 axis signaling, Toxicology Letters, 2015.2.23, (234): 201~210     

7．Guo,Jingyu; Wei,Wei; Zhan,Lixing^(*), Red and processed meat intake and risk of breast cancer:a meta-analysis of prospective studies, Breast Cancer Res Treat, 2015.4.19, 151: 191~198   

8．Liu,Fatao; Zhou,Yi; Zhou,Daizhan; Kan,Mengyuan; Niu,Xiaomin; Zhang,Zhou; Zhang,Di; Tao,Liming; He,Lin; Zhan,Lixing^(*); Liu,Yun^(*), Whole DNA methylome profiling in lung cancer cells before and after epithelial-to-mesenchymal transition, Diagnostic Pathology, 2014.3.20, 9: 66   

9．Zheng, Chao; Wang, Yuetong; Yang, Liu; Zhou, Shuhua; Gao, Yijun; Li, Fuming; Feng, Yan; Wang, Zuoyun; Zhan, Lixing; Yan, Qin; Zhu, Xueliang; Wong, Kwok-Kin; Chen, Zhengjun; Ji, Hongbin^(*), Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis, Scientific Reports, 2017.9.4, 7(1)  

10．Wang,G.; Yu,Y.; Sun,C.; Liu,T.; Liang,T.; Zhan,Lixing; Lin,X.; Feng,Xinhua^(*), STAT3 selectively interacts with Smad3 to antagonize TGF-beta signalling, Oncogene, 2016.8, 35(33): 4388~4398     

11．Gu,Shuchen; Liu,Yanjing; Zhu,Bowen; Ding,Ke; Yao,Tso-Pang; Chen,Fenfang; Zhan,Lixing; Xu,Pinglong; Marcelo,Ehrlich; Liang,Tingbo; Lin,Xia; Feng,Xin-Hua^(*), Loss of α-Tubulin Acetylation isAssociated with TGF-β-induced EpithelialMesenchymal Transition, Journal of Biological Chemistry, 2016.3.4, 291(10): 5396~5405    

12．Anczukow,Olga; Rosenberg,Avi Z.; Akerman,Martin; Das,Shipra; Zhan,Lixing; Karni,Rotem; Muthuswamy,Senthil K.; Krainer,Adrian R.^(*), The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation, Nature Structural & Molecular Biology, 2012.2, 19(2): 220~228    

13．Ju,Dapeng; Zhan,Lixing^(*),Developments in Regulation of Adipocytes Differentiation. Chinese Journal of Cell Bioligy. 32(5), 690-695     

14．Zhan,Lixing; Rosenberg,Avi; Bergami,Kenneth C.; Yu,Min; Xuan,Zhenyu; Jaffe,Aron B.; Allred,Craig; Muthuswamy,Senthil K.^(*), Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma, Cell, 2008.11.28, 135(5): 865~878   

15．Zhan,Lixing; Xiang,Bin; Muthuswamy,Senthil K.^(*), Controlled activation of ErbB1/ErbB2 heterodimers promote invasion of three-dimensional organized epithelia in an ErbB1-dependent manner: Implications for progression of ErbB2-overexpressing tumors, Cancer Research, 2006.5.15, 66(10): 5201~5208