Brief Biography
Jan 2017 – present: Professor, Principal Investigator, Shanghai Institute of Nutrition and Health (SINH), CAS
Feb 2010 – Dec 2016: Professor, Institute for Nutritional Sciences, SIBS, CAS
Nov 2004 – Feb 2010: Postdoctoral researcher, Cold Spring Harbor laboratory, New York, USA
Aug 1998 – Aug 2003: M.D., Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China
Aug 1991 – Jul 1996: Bachelor of Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

Selected Publications (*Corresponding Author)

1. Jiazheng Jiao, Lele Song, Shengjun Xu, Yuan Xue, Yanyan Liao, Keying Xu, Qian Wen, Kai Xiang, Rongrong Chen, Xiaoxia Dong, Yinlong Guo, Gang Li*, Haibiao Bao*, Xiao Xu*,Lixing Zhan*. Selenoprotein P Deficiency Drives Hepatocellular Carcinoma Progression via Induction of Neutrophil Senescence and Immunosuppressive Microenvironment. Gut. 2026, online. doi: 10.1136/gutjnl-2025-336422
2. Keying Xu, Xiaoxia Dong, Huiheng Qu, Jiayang Hu, Jiazheng Jiao, Rongrong Chen, Gang Li*, Zhaoshen Li*, Xiao Xu*, Jiazeng Xia*, and Lixing Zhan*. AF6 knockout-induced upregulation of bile acid production promotes CXCL14-mediated antitumor immunity in HCC. Journal of Hepatology. 2026, 84(5): 976-992.
3. Yingchao Liu, Jiahui Bai, Xiaoxia Dong, Yuqi Cao, Mingmai Bao, Yingjie Lu, Hui Zeng, Lixing Zhan*, Yinlong Guo*. Online Charge-Generation Derivatization by Electrochemical Radical Cations of Thianthrene: Mass Spectrometry Imaging of Estrogens in Biological Tissues. Analytical Chemistry. 2024, 96, 30, 12473–12481.
4. Xiuqi Gui, Jing Huang, Linjie Ruan, Yanjun Wu, Xuan Guo, Ruifang Cao, Shuhan Zhou, Fengxiang Tan, Hongwen Zhu, Mushan Li, Guoqing Zhang, Hu Zhou, Lixing Zhan*, Xin Liu*, Shiqi Tu*, Zhen Shao*. zMAP toolset: model-based analysis of large-scale proteomic data via a variance stabilizing z-transformation. Genome Biol. 2024, 25(1): 267.
5. Xinyu Wang, Qian Wen, Yanjun Wu, Jingwen Kong, Keying Xu, Jiazheng Jiao, Haibing Zhang*, Kai Wang*, Xiao Xu*,Lixing Zhan*. Polarity protein AF6 functions as a modulator of necroptosis by regulating ubiquitination of RIPK1 in liver diseases. Cell Death and Disease, 2023, 14:673.
6. Yanjun Wu, Lele Song, Jingwen Kong, Qian Wen, Jiazheng Jiao, Xinyu Wang, Gang Li, Xiao Xu*, Lixing Zhan*. Scribble promotes fibrosis-dependent mechanisms of hepatocarcinogenesis by p53/PUMA-mediated glycolysis. Biochim Biophys Acta Mol Basis Dis, 2023, 1869(8):166823.
7. Meiyan Qi, Yun Xia, Yanjun Wu, Zhuo Zhang, Xinyu Wang, Liying Lu, Cheng Dai, Yanan Song, Keying Xu, Weiwei Ji, Lixing Zhan*. Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression. Nature Communications, 2022, 13:897.
8. Lele Song, Renxu Chang, Xia Sun; Liying Lu, Han Gao, Huiying Lu, Ritian Lin, Xiaorong Xu, Zhanju Liu*, Lixing Zhan*. Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice, Communications Biology. 2021, 4(1): 213.
9. Cheng Dai, Xinyu Wang, Yanjun Wu, Yi Xu, Shu Zhuo, Meiyan Qi, Weiwei Ji, Lixing Zhan*. Polarity Protein AF6 Controls Hepatic Glucose Homeostasis and Insulin Sensitivity by Modulating IRS1/AKT Insulin Pathway in a SHP2-dependent Manner. Diabetes. 2019, 68:1577-1590.
10. Na Wang, Lele Song, Yi Xu, Longfu Zhang, Yanjun Wu, Jingyu Guo, Weiwei Ji, Li Li, Jingya Zhao, Xin Zhang*, Lixing Zhan*. Loss of Scribble confers cisplatin resistance during NSCLC chemotherapy via Nox2/ROS and Nrf2/PD-L1 signaling. EBioMedicine. 2019,47:65-77.
11. Renxu Chang, Lele Song, Yi Xu, Yanjun Wu, Cheng Dai, Xinyu Wang, Xia Sun, Yingyong Hou, Wei Li, Xiaobao Zhan, Zhan,Lixing*, Loss of Wwox drives metastasis 1 in triple-negative breast cancer by upregulating the IL6/JAK2/STAT3 axis, Nature Communications. 2018, 9:3486.
12. Xiaojiao Li, Lele Song, Xingjie Hu, Chang Liu, Jiye Shi, Hui Wang*, Lixing Zhan*, Haiyun Song*. Inhibition of Epithelial-Mesenchymal Transition and Tissue Regeneration by Waterborne Titanium Dioxide Nanoparticles, ACS Appl Mater Interfaces, 2018, 10(4): 3449-3458.
13. Yi Zhou, Renxu Chang, Weiwei Ji, Na Wang, Meiyan Qi, Yi Xu, Jingyu Guo, Lixing Zhan *. Loss of Scribble Promotes Snail Translation through Translocation of HuR and Enhances Cancer Drug Resistance. Journal of Biological Chemistry. 2016, 291(1):291-302.
14. Yi Xu, Renxu Chang, Zhiyong Peng, Yanmei Wang, Weiwei Ji, Jingyu Guo, Lele Song, Cheng Dai, Wei Wei, Yanjun Wu, Xinjian Wan, Chenghao Shao, Lixing Zhan*. Loss of polarity protein AF6 promotes pancreatic cancer metastasis by inducing Snail expression. Nat Commun. 2015, 6:7184.
15. Lixing Zhan, Avi Rosenberg, Kenneth C Bergami, Min Yu, Zhenyu Xuan, Aron B Jaffe, Craig Allred, Senthil K Muthuswamy*. Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma. Cell. 2008, 135(5):865-78.
16. Lixing Zhan, Bin Xiang, Senthil K. Muthuswamy*.Controlled Activation of ErbB1/ErbB2 Heterodimers Promote Invasion of Three-Dimensional Organized Epithelia in an ErbB1-Dependent Manner: Implications for Progression of ErbB2-Overexpressing Tumor. Cancer Res. 2006, 66(10):5201-5208.