Home >> People >> Faculty
ZHAN Lixing


Professor, Principal Investigator

Laboratory of Cell Polarity & Cancer Metabolism

Email: lxzhan@sibs.ac.cn

Tel: 86-21-54920978

Research Areas: 

Disruption of cell polarity is an important hallmark of cancer. The role polarity proteins play during tumorigenesis is poorly understood. Using cell culture studies and mouse tumor models, we will identify novel polarity pathways play in normal cell architecture and tissue morphogenesis. Through the molecular analysis of aberrant genetic and epigenetic pathways in epithelia cancer, we want to characterize the molecular basis of cell architecture during tumor initiation and identify potential diagnosis marker or drug targets. 


Brief Biography: 

Jan 2017 – present  Professor, Principal Investigator, Shanghai Institute of Nutrition and Health (SINH), CAS 

Feb 2010 – Dec 2016  Professor, Institute for Nutritional Sciences, SIBS, CAS

Nov 2004 – Feb 2010  Postdoctoral researcher, Cold Spring Harbor laboratory, New York, USA

Aug 1998 – Aug 2003  M.D., Second Military Medical University, Dept. of gastroenterology of changhai hospital, Shanghai, China

Aug 1991Jul 1996  Bachelor of Medicine, Zhejiang University School of Medicine.Hangzhou, Zhejiang, China


Selected Publications:*Corresponding Author 

1Chang,Renxu; Song,Lele; Xu,Yi; Wu,Yanjun; Dai,Cheng; Wang,Xinyu; Sun,Xia; Hou,Yingyong; Li,Wei; Zhan,Xiaobao; Zhan,Lixing(*), Loss of Wwox drives metastasis 1 in triple-negative breast cancer by upregulating the IL6/JAK2/STAT3 axis, nature communicationsaccepted  

2Li,Xiaojiao; Song,Lele; Hu,Xingjie; Liu,Chang; Shi,Jiye; Wang,Hui(*); Zhan,Lixing(*); Song,Haiyun(*), Inhibition of Epithelial-Mesenchymal Transition and Tissue Regeneration by Waterborne Titanium Dioxide Nanoparticles, ACS Appl Mater Interfaces, 2018.1.10, 10(4): 3449~3458     

3Zhou,Yi; Chang,Renxu; Ji,Weiwei; Wang,Na; Qi,Meiyan; Xu,Yi; Guo,Jingyu; Zhan,Lixing(*), Loss of Scribble Promotes Snail Translation through Translocation of HuR and Enhances Cancer Drug Resistance, Journal of Biological Chemistry, 2016.1.1, 291(1): 291~302  

4Xu,Yi; Chang,Renxu; Peng,Zhiyong; Wang,Yanmei; Ji,Weiwei; Guo,Jingyu; Song,Lele; Dai,Cheng; Wei,Wei; Wu,Yanjun; Wan,Xinjian; Shao,Chenghao; Zhan,Lixing(*), Loss of polarity protein AF6 promotes pancreatic cancer metastasis by inducing Snail expression, Nature Communications, 2015.5, 6: 7184      

5Song,Lele; Chang,Renxu; Dai,Cheng; Wu,Yanjun; Guo,Jingyu; Qi,Meiyan; Zhou,Wu(*); Zhan,Lixing(*), SORBS1 suppresses tumor metastasis and improves the sensitivity of cancerto chemotherapy drug, Oncotarget, 2016.10.24, 8(6): 9108~9122      

6Guo,Jingyu; Xu,Yi; Ji,Weiwei; Song,Lele; Dai,Cheng; Zhan,Lixing(*), Effects of exposure to benzo[a]pyrene on metastasis of breast cancer are mediated through ROS-ERK-MMP9 axis signaling, Toxicology Letters, 2015.2.23, (234): 201~210     

7Guo,Jingyu; Wei,Wei; Zhan,Lixing(*), Red and processed meat intake and risk of breast cancer:a meta-analysis of prospective studies, Breast Cancer Res Treat, 2015.4.19, 151: 191~198   

8Liu,Fatao; Zhou,Yi; Zhou,Daizhan; Kan,Mengyuan; Niu,Xiaomin; Zhang,Zhou; Zhang,Di; Tao,Liming; He,Lin; Zhan,Lixing(*); Liu,Yun(*), Whole DNA methylome profiling in lung cancer cells before and after epithelial-to-mesenchymal transition, Diagnostic Pathology, 2014.3.20, 9: 66   

9Zheng, Chao; Wang, Yuetong; Yang, Liu; Zhou, Shuhua; Gao, Yijun; Li, Fuming; Feng, Yan; Wang, Zuoyun; Zhan, Lixing; Yan, Qin; Zhu, Xueliang; Wong, Kwok-Kin; Chen, Zhengjun; Ji, Hongbin(*), Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis, Scientific Reports, 2017.9.4, 7(1)  

10Wang,G.; Yu,Y.; Sun,C.; Liu,T.; Liang,T.; Zhan,Lixing; Lin,X.; Feng,Xinhua(*), STAT3 selectively interacts with Smad3 to antagonize TGF-beta signalling, Oncogene, 2016.8, 35(33): 4388~4398     

11Gu,Shuchen; Liu,Yanjing; Zhu,Bowen; Ding,Ke; Yao,Tso-Pang; Chen,Fenfang; Zhan,Lixing; Xu,Pinglong; Marcelo,Ehrlich; Liang,Tingbo; Lin,Xia; Feng,Xin-Hua(*), Loss of α-Tubulin Acetylation isAssociated with TGF-β-induced EpithelialMesenchymal Transition, Journal of Biological Chemistry, 2016.3.4, 291(10): 5396~5405    

12Anczukow,Olga; Rosenberg,Avi Z.; Akerman,Martin; Das,Shipra; Zhan,Lixing; Karni,Rotem; Muthuswamy,Senthil K.; Krainer,Adrian R.(*), The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation, Nature Structural & Molecular Biology, 2012.2, 19(2): 220~228    

13Ju,Dapeng; Zhan,Lixing(*),Developments in Regulation of Adipocytes Differentiation. Chinese Journal of Cell Bioligy. 32(5), 690-695     

14Zhan,Lixing; Rosenberg,Avi; Bergami,Kenneth C.; Yu,Min; Xuan,Zhenyu; Jaffe,Aron B.; Allred,Craig; Muthuswamy,Senthil K.(*), Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma, Cell, 2008.11.28, 135(5): 865~878   

15Zhan,Lixing; Xiang,Bin; Muthuswamy,Senthil K.(*), Controlled activation of ErbB1/ErbB2 heterodimers promote invasion of three-dimensional organized epithelia in an ErbB1-dependent manner: Implications for progression of ErbB2-overexpressing tumors, Cancer Research, 2006.5.15, 66(10): 5201~5208