Brief Biography
Jan 2017 – present: Professor, Principal Investigator, Shanghai Institute of Nutrition and Health (SINH), CAS
Feb 2010 – Dec 2016: Professor, Institute for Nutritional Sciences, SIBS, CAS
Nov 2004 – Feb 2010: Postdoctoral researcher, Cold Spring Harbor laboratory, New York, USA
Aug 1998 – Aug 2003: M.D., Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China
Aug 1991 – Jul 1996: Bachelor of Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

Selected Publications (*Corresponding Author)

1. Lu L, Xu K, Qu H, Song L, Song Y, Wu Y, Sun X, Kong J, Wen Q, Jiao J, Liu Z, Xia J, Zhan L*. AF6 regulates intestinal IgA via crosstalk between intestinal epithelial cells and immune cells in inflammatory bowel disease. iScience 2025 May 13;28(7):112658.
2. Wu Y, Song L, Kong J, Wen Q, Jiao J, Wang X, Li G, Xu X, Zhan L*. Scribble promotes fibrosis-dependent mechanisms of hepatocarcinogenesis by p53/PUMA-mediated glycolysis. Biochim Biophys Acta Mol Basis Dis 2023 Dec;1869(8):166823.
3. Qi M#, Xia Y#, Wu Y, Zhang Z, Wang X, Lu L, Dai C, Song Y, Xu K, Ji W, Zhan L*. Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression. Nat Commun 2022 Feb 16;13(1):897.
4. Song L, Chang R, Sun X, Lu L, Gao H, Lu H, Lin R, Xu X, Liu Z, Zhan L*. Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice. Commun Biol 2021 Feb 16;4(1):213.
5. Dai C, Wang X, Wu Y, Xu Y, Zhuo S, Qi M, Ji W, Zhan L*. Polarity Protein AF6 Controls Hepatic Glucose Homeostasis and Insulin Sensitivity by Modulating IRS1/AKT Insulin Pathway in an SHP2-Dependent Manner. Diabetes 2019 Aug;68(8):1577-1590.
6. Lin J, Wu YJ, Liang X, Ji M, Ying HM, Wang XY, Sun X, Shao CH, Zhan LX*, Zhang Y*. Network-based integration of mRNA and miRNA profiles reveals new target genes involved in pancreatic cancer. Mol Carcinog 2019 Feb;58(2):206-218.
7. Chang R, Song L, Xu Y, Wu Y, Dai C, Wang X, Sun X, Hou Y, Li W, Zhan X, Zhan L*. Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis. Nat Commun 2018 Aug 28;9(1):3486.
8. Li X, Song L, Hu X, Liu C, Shi J, Wang H*, Zhan L*, Song H*. Inhibition of Epithelial-Mesenchymal Transition and Tissue Regeneration by Waterborne Titanium Dioxide Nanoparticles. ACS Appl Mater Interfaces 2018 Jan 31;10(4):3449-3458.
9. Zhou Y, Chang R, Ji W, Wang N, Qi M, Xu Y, Guo J, Zhan L*. Loss of Scribble Promotes Snail Translation through Translocation of HuR and Enhances Cancer Drug Resistance. J Biol Chem 2016 Jan 1;291(1):291-302.
10. Xu Y, Chang R, Peng Z, Wang Y, Ji W, Guo J, Song L, Dai C, Wei W, Wu Y, Wan X, Shao C, Zhan L*. Loss of polarity protein AF6 promotes pancreatic cancer metastasis by inducing Snail expression. Nat Commun 2015 May 26;6:7184.
11. Song L, Chang R, Dai C, Wu Y, Guo J, Qi M, Zhou W*, Zhan L*. SORBS1 suppresses tumor metastasis and improves the sensitivity of cancer to chemotherapy drug. Oncotarget 2017 Feb 7;8(6):9108-9122.
12. Guo J, Xu Y, Ji W, Song L, Dai C, Zhan L*. Effects of exposure to benzo[a]pyrene on metastasis of breast cancer are mediated through ROS-ERK-MMP9 axis signaling. Toxicol Lett 2015 May 5;234(3):201-210.
13. Guo J, Wei W, Zhan L*. Red and processed meat intake and risk of breast cancer: a meta-analysis of prospective studies. Breast Cancer Res Treat 2015 May;151(1):191-198.
14. Liu F, Zhou Y, Zhou D, Kan M, Niu X, Zhang Z, Zhang D, Tao L, He L, Zhan L*, Liu Y*. Whole DNA methylome profiling in lung cancer cells before and after epithelial-to-mesenchymal transition. Diagn Pathol 2014 Mar 20;9:66.
15. Zheng C, Wang Y, Yang L, Zhou S, Gao Y, Li F, Feng Y, Wang Z, Zhan L, Yan Q, Zhu X, Wong KK, Chen Z, Ji H*. Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis. Sci Rep 2017 Sep 4;7(1):10407.
16. Wang G, Yu Y, Sun C, Liu T, Liang T, Zhan L, Lin X, Feng XH*. STAT3 selectively interacts with Smad3 to antagonize TGF-beta signalling. Oncogene 2016 Aug 18;35(33):4388-4398.
17. Gu S, Liu Y, Zhu B, Ding K, Yao TP, Chen F, Zhan L, Xu P, Ehrlich M, Liang T, Lin X, Feng XH*. Loss of α-Tubulin acetylation is associated with TGF-β-induced Epithelial-Mesenchymal Transition. J Biol Chem 2016 Mar 4;291(10):5396-5405
18. Anczuków O, Rosenberg AZ, Akerman M, Das S, Zhan L, Karni R, Muthuswamy SK, Krainer AR*. The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation. Nat Struct Mol Biol 2012 Jan 15;19(2):220-228.
19. Ju D, Zhan L*. Developments in Regulation of Adipocytes Differentiation. Chinese Journal of Cell Bioligy 2010 Oct;32(5):690-695.
20. Zhan L, Rosenberg A, Bergami KC, Yu M, Xuan Z, Jaffe AB, Allred C, Muthuswamy SK*. Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma. Cell 2008 Nov 28;135(5):865-878.
21. Zhan L, Xiang B, Muthuswamy SK*. Controlled activation of ErbB1/ErbB2 heterodimers promote invasion of three-dimensional organized epithelia in an ErbB1-dependent manner: implications for progression of ErbB2-overexpressing tumors. Cancer Res 2006 May 15;66(10):5201-5208.