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YANG Huangtian


Professor, Principal Investigator

Laboratory of Molecular Cardiology

Email: htyang@@sibs.ac.cn

Research Areas:

The long-term goal of Dr. Yang′s lab is to identify the mechanisms that underlie the physiological and pathological alterations in cardiac contractile function, myocardial ischemia/reperfusion injury and protection, and myocardial repair; and to develop novel targets and therapeutic strategies related to prevention and treatment of ischemic diseases and heart failure. The lab is currently conducting the researches in the following aspects:
1. Identification of regulatory mechanisms underlying cardiomyocyte fate decision of pluripotent stem cells and development of effective cardiac differentiation approaches;
2. Characterization of pluripotent stem cell-derived cardiomyocytes and application in myocardial repair and drug screen;
3. Elucidation of the regulatory mechanisms underlying Ca2+ signaling in cardiogenesis, and protection;
4. Exploration of the new effect and mechanisms of intermittent hypoxic adaptation-, natural compounds- and endogenous factors-induced cardioprotection against ischemic injury and explore their therapeutic significance.


Brief Biography:

1978 - 1982: B.S in Medicine, Nantong Medical College, China
1985 - 1988: M.D in Medicine, Su Zhou Medical College, China
1992 - 1994: Ph.D. in Medicine, Yamagata University, School of Medicine, Japan

Major Academic Appointments
1982 - 1985: Instructor, Nantong Medical College, China
1989 - 1992: Assistant Professor, Nantong Medical College, China
1992 - 1997: Instructor, research fellow, Dept. of Pharmacology, Yamagata University School of Medicine, Japan
1997 - 2001: Researcher fellow, Laboratory of Cardiovascular Science, Gerontology Research Center, NIA, NIH, USA
2000 - 2016: Principal Investigator, Professor, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine
2003 - 2004: Director Assistant, Institute of Health Sciences, SIBS, CAS/SJTUSM, China
2005 - 2014: Associate Director, Institute of Health Sciences, SIBS, CAS/SJTUSM, China
2017 - Present: Professor, Principal Investigator, Shanghai Institute of Nutrition and Health, CAS


American Heart Association/American Stroke Association Professional Membership
Chinese Association for Physiological Sciences, Circulation Committee (Council member)
Chinese Association of Pathophysiology, Cardiovascular Sciences and Receptor/Signal Transduction Professional Committee (Council member)
Chinese Association of Plastics and Aesthetics Branch of Stem Cell & Application (Executive member
Chinese Medical Association for Cardiovascular Disease Branch (Council member)
Chinese Pharmacological Society for Cardiovascular Pharmacology (member of the standing committee)
Chinese Medical Association for Heart Regeneration (Council member)
Chinese Society of Cardiovascular Pharmacology (Council member)
International Society for Heart Research-China Section (Vice Chairman)
Shanghai Society for Cell Biology (Vice-Chairman)
The International Society for Heart Research (Fellow)
The 11th Council of the Chinese Association of Pathophysiology (Council member)


Acta Pharmacol. Sinica
Acta Physiologica Sinica (Editorial Board of the Standing Committee)
AJP-Heart and Circulatory Physiology
Cardiovascular Drugs and Therapy
Cell Death Disease
Chinese Journal of Applied Physiology
Chinese Journal of Molecular Cardiology
Current Opinion in Physiology
Engineering-Tissue Engineering
Frontier in Pharmacology
J Mol Cell Cardiol (Associate Editor)
Pflügers Archiv - European Journal of Physiology (Executive Editor)


Selected Publications: (# Contributed equally, * Corresponding Author)

  1. Jiang Y, Zhang LL, Zhang F, Bi W, Zhang P, Yu YJ, Rao SL, Wang SH, Li Q, Ding C, Jin Y, Liu ZM, Yang HT*. Dual human iPSC-derived cardiac lineage cell-seeding extracellular matrix patches promote regeneration and long-term repair of infarcted hearts. Bioact Mater 2023 Oct;28:206-226.
  2. Luo XX, Jiang Y, Li Q, Yu XJ, Ma T, Cao H, Ke MX, Zhang P, Tan JL, Gong YS, Wang L, Gao L*, Yang HT*. hESC‐derived epicardial cells promote repair of infarcted hearts in mouse and swine. Adv Sci (Weinh) 2023 Sep;10(27):2300470.
  3. Gao L*, Qiu F, Cao H, Li H, Dai G, Ma T, Gong Y, Luo W, Zhu D, Qiu Z, Zhu P, Chu S*, Yang HT*, Liu Z*. Therapeutic delivery of microRNA-125a-5p oligonucleotides improves recovery from myocardial ischemia/reperfusion injury in mice and swine. Theranostics 2023 Jan;13(2):685-703.
  4. Li XX#, Zhang P#, Yang Y#, Wang JJ, Zheng YJ, Tan JL, Liu SY, Yan YM, Zhang YY, Cheng YX*, Yang HT*. Small molecule QF84139 ameliorates cardiac hypertrophy via activating the AMPK signaling pathway. Acta Pharmacol Sin 2022 Mar;43(3):588-601.
  5. Li J, Wang K, Zhang Y, Qi T, Yuan J, Zhang L, Qiu H, Wang J, Yang HT, Dai Y, Song Y, Chang X*. Therapeutic exon skipping via a CRISPR-guided cytidine deaminase rescues dystrophic cardiomyopathy in vivo. Circulation 2021 Nov;144(22):1760-1776.
  6. Luo XL, Zhang P, Liu X, Huang S, Rao SL, Ding Q, Yang HT*. Myosin light chain 2 marks differentiating ventricular cardiomyocytes derived from human embryonic stem cells. Pflügers Archiv - Eur J Physiol 2021 Jul;473(7):991-1007.
  7. Bi W#, Wang JX#, Jiang Y, Li Q, Wang SH, Liu ML, Liu Q, Li F, Paul C, Wang YG, Yang HT*. Neurotrophin-3 contributes to benefits of human embryonic stem cell-derived cardiovascular progenitor cells against reperfused myocardial infarction. Stem Cells Transl Med 2021 May;10(5):756-772.
  8. Chu LM, Yin HM, Gao L, Xia Yu, Zhang CY, Chen Y, Liu TX, Huang JJ, Boheler KR, Zhou Y*, Yang HT*. Cardiac Na+-Ca2+ exchanger 1 (ncx1h) is critical for the ventricular cardiomyocyte formation via regulating the expression levels of gata4 and hand2 in zebrafish. Sci China Life Sci 2021 Feb;64(2):255-268.
  9. Xing M#, Jiang Y#, Bi W, Gao L, Zhou YL, Rao SL, Ma LL, Zhang ZWB, Yang HT*, Chang J*. Strontium ions protect the hearts against myocardial ischemia/reperfusion injury. Sci Adv 2021 Jan 15;7(3):eabe0726.
  10. Zhang P, Huang JJ, Ou-yang KF, Liang H, Li ML, Wang YJ, Yang HT*. Minimal contribution of IP3R2 in cardiac differentiation and derived ventricular-like myocytes from human embryonic stem cells. Acta Pharmacologica Sinica 2020 Dec;41(12):1576-1586.
  11. Gu SS, Tan JL, Li Q, Liu SY, Ma J,Zheng YJ, Liu JL, Bi W, Sha P, Li XX, Wei M, Cao N*, Yang HT*. Downregulation of LAPTM4B Contributes to the Impairment of the Autophagic Flux via Unopposed Activation of mTORC1 Signaling during Myocardial Ischemia/Reperfusion Injury. Circ Res 2020 Sep 11;127(7):e148-e165.
  12. Poon E*, Luo XL, Webb S, Yan B, Zhao R, Wu S, Yang Y, Zhang P, Bai HJ, Shao JF, Chan C, Chan G, Tsang S, Gundry R, Yang HT, Boheler K*. The Cell Surface Marker CD36 Selectively identifies Matured, Mitochondria-rich hPSC-Cardiomyocytes. Cell Res 2020 Jul;30(7):626-629.
  13. Liang H#, Zhang P#, Bai H J#, Huang JJ, Yang HT*. TATA-box-binding protein-related factor 3 drives the mesendoderm specification of human embryonic stem cells by globally interacting with the TATA box of key mesendodermal genes. Stem Cell Res Ther 2020 May 24;11(1):196.
  14. Wu Q#, Wang JX#, Tan WLW, Jiang Y, Wang SH, Li Q, Yu XJ, Tan JL, Liu SY, Zhang P, Tiang Z, Chen ZY, Foo RSY, Yang HT*. Extracellular vesicles from human embryonic stem cell-derived cardiovascular progenitor cells promote cardiac infarct healing through reducing cardiomyocyte death and promoting angiogenesis. Cell Death & Disease 2020 May 11;11(5):354.
  15. Liu YP#, Bai HJ#, Yang CL, Luo XL, Zhang P, Guo FF, Fen XQ, Phung T, Zhu D, Guo J, Liang P, Xu Z, Yang HT*, Lu XY*. PGC-1α Activator ZLN005 Promotes Maturation of Cardiomyocytes Derived from Human Embryonic Stem Cells. Aging 2020 Apr 28;12(8):7411-7430.
  16. Hu JL#, Liang H#, Zhang H#, Yang MZ#, Sun W, Zhang P, Luo L, Feng JX, Bai HJ, Liu F, Zhang TP, Yang JY, Gao QS, Long YK, Ma XY, Chen Y, Zhong Q, Yu B, Liao S, Wang YB, Zhao Y, Zeng MS, Cao N, Wang JC, Chen W*, Yang HT*, Gao S*. FAM46B is a prokaryote-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells. Nucleic Acids Res 2020 Mar 18;48(5):2733-2748.
  17. Bai HJ, Zhang P, Ma L, Liang H, Wei G, Yang HT*. SMYD2 drives mesendodermal differentiation of human embryonic stem cells through mediating the transcriptional activation of key mesendodermal genes. Stem Cells 2019 Nov;37(11):1401-1415.
  18. Rusinkevich V, Huang Y, Chen ZY, Qiang W, Wang YG, Shi YF, Yang HT*. Temporal dynamics of immune response following prolonged myocardial ischemia/reperfusion with and without cyclosporine A. Acta Pharmacol Sin 2019 Sep;40(9):1168-1183.
  19. Wang JX, Liu ML, Wu Q, Li Q, Gao L, Jiang Y, Deng B, Huang W, Bi W, Chen Z, Chin Y, Paul C, Wang Y, Yang HT*. Human Embryonic Stem Cell-Derived Cardiovascular Progenitors Repair Infarcted Hearts through Modulation of Macrophages via Activation of STAT6. Antioxid Redox Signal 2019 Aug 10;31(5):369-386.
  20. Tan JL, Gu SS, Zheng YJ, Yang HT. Expression Profile of Circular RNAs in Myocardial Ischemia/Reperfusion with and without Intermittent Hypobaric Hypoxia Preconditioning. Sci China Life Sci 2019 Aug;62(8):1104-1106.
  21. Fang X, Wang H, Han D, Xie E, Yang X, Wei J, Gu S, Gao F, Zhu N, Yin X, Cheng Q, Zhang P, Dai W, Chen J, Yang F, Yang HT, Linkermann A, Gu W, Min J, Wang F. Ferroptosis as a target for protection against cardiomyopathy. Proc Natl Acad Sci U S A 2019 Feb 12;116(7):2672-2680.
  22. Wang X, Wang L, Wu Q, Bao F, Yang HT*, Qiu X*, Chang J*. Chitosan/Calcium Silicate Cardiac Patch Stimulates Cardiomyocyte Activity and Myocardial Performance after Infarction by Synergistic Effect of Bioactive Ions and Aligned Nanostructure. ACS Appl Mater Interfaces 2019 Jan 9;11(1):1449-1468.
  23. Zhu K, Wu Q, Ni C, Zhang P, Zhong Z, Wu Y, Wang Y, Xu Y, Kong M, Cheng H, Tao Z, Yang Q, Liang H, Jiang Y, Li Q, Zhao J, Huang J, Zhang F, Chen Q, Li Y, Chen J, Zhu W, Yu H, Zhang J, Yang HT*, Hu X*, Wang J*. Lack of remuscularization following transplantation of human embryonic stem cell-derived cardiovascular progenitor cells in infarcted nonhuman primates. Circ Res 2018 Mar 30;122(7):958-969.
  24. Wang YJ, Huang J, Liu W, Kou X, Tang H, Wang H, Yu X, Gao S, Ouyang K, Yang HT*. IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway. J Mol Cell Biol 2017 Aug 1;9(4):274-288. (cover article)
  25. Chen ZY, Chen F, Cao N, Zhou ZW, Yang HT*. miR-142-3p contributes to early cardiac fate decision of embryonic stem cells. Stem Cells Int 2017;2017:1769298.
  26. Lu J, Kaestle K, Huang J, Liu Q, Zhang P, Gao L, Gardiner J, Thissen H, Yang HT*. Interactions of human embryonic stem cell-derived cardiovascular progenitor cells with immobilized extracellular matrix proteins. J Biomed Mater Res A 2017 Apr;105(4):1094-1104.
  27. Zheng Y, Gu S, Li X, Tan J, Liu S, Jiang Y, Zhang C, Gao L, Yang HT*. Berbamine postconditioning protects the heart from ischemia/reperfusion injury through modulation of autophagy. Cell Death Dis 2017 Feb 2;8(2):e2577.
  28. Wang Z, Zhang XJ, Ji YX, Zhang P, Deng KQ, Gong J, Ren S, Wang X, Chen I, Wang H, Gao C, Yokota T, Ang YS, Li S, Cass A, Vondriska TM, Li G, Deb A, Srivastava D, Yang HT, Xiao X, Li H, Wang Y. The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy. Nat Med 2016 Oct;22(10):1131-1139.
  29. Huang J, Zhang M, Zhang P, Liang H, Ouyang K, Yang HT*. Coupling switch of P2Y-IP3 receptors mediates differential Ca2+ signaling in human embryonic stem cells and derived cardiovascular progenitor cells. Purinergic Signal 2016 Sep;12(3):465-478.
  30. Tang Y, Hong YZ, Bai HJ, Wu Q, Chen CD, Lang JY, Boheler KR, Yang HT*. PHF8 regulates mesodermal and cardiac differentiation of embryonic stem cells through mediating the histone demethylation of pmaip1. Stem Cells 2016 Jun;34(6):1527-1540.
  31. Wu L, Tan JL, Wang ZH, Chen YX, Gao L, Liu JL, Yun-Hua S, Endoh M, Yang HT*. ROS generated during early reperfusion contribute to intermittent hypobaric hypoxia-afforded cardioprotection against postischemia-induced Ca2+ overload and contractile dysfunction via the JAK2/STAT3 pathway. J Mol Cell Cardiol 2015 Apr;81:150-161.
  32. Chen YX, Liu JL, Zheng YJ, Wang JX, Wang ZH, Gu SS, Tan JL, Jing Q, Yang HT*. Uncoupling Protein 3 Mediates H2O2 Preconditioning-Afforded Cardioprotection through the Inhibition of MPTP Opening. Cardiovasc Res 2015 Feb 1;105(2):192-202.
  33. Ling Gao, Yanjun Zheng, Shanshan Gu, Jiliang Tan, Christian Paul, Yigang Wang, Huangtian Yang*. Degradation of cardiac myosin light chain kinase by matrix metalloproteinase-2 contributes to myocardial contractile dysfunction during ischemia/reperfusion. J Mol Cell Cardiol 2014 Dec;77:102-112.
  34. Tang Y, Chen ZY, Hong YZ, Wu Q, Lin HQ, Chen CD, Yang HT*. Expression profiles of histone lysine demethylases during cardiomyocyte differentiation of mouse embryonic stem cells. Acta Pharmacol Sin 2014 Jul;35(7):899-906.
  35. Wang ZH, Liu JL, Wu L, Yu Z, Yang HT*. Concentration-dependent wrestling between detrimental and protective effects of H2O2 during myocardial ischemia/reperfusion. Cell Death Dis 2014 Jun 19;5:e1297.
  36. Gao L, Chen L, Lu ZZ, Gao H, Wu L, Chen YX, Zhang CM, Jiang YK, Jing Q, Zhang Y, Yang HT*. Activation of α1B-adrenoceptors contributes to intermittent hypobaric hypoxia-improved post-ischemic myocardial performance via inhibiting MMP-2 activation. Am J Physiol Heart Circ Physiol 2014 Jun 1;306(11):H1569-H1581.
  37. Cao N, Liang H, Huang J, Wang J, Chen Y, Chen Z, Yang HT*. Highly efficient induction and long-term maintenance of multipotent cardiovascular progenitors from human pluripotent stem cells under defined conditions. Cell Res 2013 Sep;23(9):1119-1132.
  38. Zhang CM, Gao L, Zheng YJ, Yang HT*. Berbamine Protects the Heart From Ischemia/Reperfusion Injury by Maintaining Cytosolic Ca2+ Homeostasis and Preventing Calpain Activation. Circ J 2012;76(8):1993-2002.
  39. Wang ZH, Cai XL, Wu L, Zhuo Y, Liu JL, Zhou ZN, Liu JK, Yang HT*. Mitochondrial Energy Metabolism Plays a Critical Role in the Cardioprotection Afforded by Intermittent Hypobaric Hypoxia. Exp Physiol 2012 Oct;97(10):1105-1118.
  40. Wang J, Cao N, Yuan M, Cui H, Tang Y, Qin LJ, Huang X, Shen N, Yang HT*. MicroRNA-125b/Lin28 pathway contributes to the mesendodermal fate decision of embryonic stem cells. Stem Cells Dev 2012 Jun 10;21(9):1524-1537.
  41. Cao N, Liu Z, Chen Z, Wang J, Chen T, Zhao X, Ma Y, Qin L, Kang J, Wei B, Wang L, Jin Y, Yang HT*. Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells through promoting the proliferation of cardiac progenitor cells. Cell Res 2012 Jan;22(1):219-236.
  42. Wang ZH, Chen YX, Zhang CM, Wu L, Yu Z, Cai XL, Guan Y, Zhou ZN, Yang HT*. Intermittent Hypobaric Hypoxia Improves Post-ischemic Recovery of Myocardial Contractile Function via Redox Signaling during Early Reperfusion. Am J Physiol Heart Circ Physiol 2011 Oct;301(4):H1695-H1705.
  43. Cao N, Liao J, Liu Z, Zhu W, Wang J, Liu L, Yu L, Xu P, Cui C, Xiao L, Yang HT*. In vitro differentiation of rat embryonic stem cells into functional cardiomyocytes. Cell Res 2011 Sep;21(9):1316-1331.
  44. Zhang CM, Gao L, Zheng YJ, Yang HT*. Berbamine Increases Myocardial Contractility via a Ca2+-independent Mechanism. J Cardiovasc Pharmacol 2011 Jul;58(1):40-48.
  45. Xu WQ, Yu Z, Xie Y, Huang GQ, Shu XH, Zhu Y, Zhou ZN, Yang HT*. Therapeutic effect of intermittent hypobaric hypoxia on myocardial infarction in rats. Basic Res Cardiol 2011 May;106(3):329-342.
  46. Liang J, Wang YJ, Tang Y, Cao N, Wang J, Yang HT*. Type 3 inositol 1,4,5-trisphosphate receptor negatively regulates apoptosis during mouse embryonic stem cell differentiation. Cell Death Differ 2010 Jul;17(7):1141-1154.
  47. Guo A, Yang HT*. Ca2+ removal mechanisms in mouse embryonic stem cell-derived cardiomyocytes. Am J Physiol Cell Physiol 2009 Sep;297(3):C732-C741.
  48. Yu Z, Wang ZH, Yang HT*. Calcium/calmodulin-dependent protein kinase II mediates cardioprotection of intermittent hypoxia against ischemic-reperfusion-induced cardiac dysfunction. Am J Physiol Heart Circ Physiol 2009 Aug;297(2):H735-H742.
  49. Yang WW, Shu B, Zhu Y, Yang HT*. E2F6 Inhibits Cobalt Chloride-Mimetic Hypoxia-induced Apoptosis through E2F1. Mol Biol Cell 2008 Sep;19(9):3691-3700. (cover article)
  50. Xiyuan Lu, Le Chen, Xiaolong Cai, Huangtian Yang*. Overexpression of heat shock protein 27 against ischemia/reperfusion-induced cardiac contractile dysfunction via stabilization of troponin I and troponin T. Cardiovasc Res 2008 Aug 1;79(3):500-508.
  51. Huimei Yu, Jing Wen, Rong Wang, Wanhua Shen, Shumin Duan, Huangtian Yang*. Critical role of type 2 ryanodine receptor in mediating activing-depent neurogensis from embryonic stem cells. Cell Calcium 2008 Jun;43:417-431.
  52. Rong Wang, Ji Liang, Lianju Qin, Huangtian Yang*. Promoter-dependent EGFP expressions during embryonic stem cell propagation and differentiation. Stem Cells Dev 2008 Apr;17(2):279-289.
  53. Shu B, Yang WW, Yang HT*. Expression pattern of E2F6 in physical and chemical hypoxia-induced apoptosis. Sheng Li Xue Bao 2008 Feb 25;60(1):1-10.
  54. Gao H, Chen L, Yang HT*. Activation of alpha(1B)-adrenoceptors alleviates ischemia/reperfusion injury by limitation of mitochondrial Ca2+ overload in cardiomyocytes. Cardiovasc Res 2007 Aug 1;75(3):584-595.
  55. Li J, Zhang H, Zhu WZ, Yu Z, Guo A, Yang HT*, Zhou ZN. Preservation of the pHi during ischemia via PKC by intermittent hypoxia. Biochem Biophys Res Commun 2007 May 4;356(2):329-333.
  56. Yang WW, Wang ZH, Zhu Y, Yang HT*. E2F6 negatively regulates ultraviolet-induced apoptosis via modulation of BRCA1. Cell Death Differ 2007 Apr;14(4):807-817.
  57. Jidong Fu, Huimei Yu, Rong Wang, Ji Liang, Huangtian Yang*. Developmental regulation of intracellular calcium transients during cardiomyocyte differentiation of mouse embryonic stem cells. Acta Pharmacol Sin 2006 Jul;27(7):901-910.
  58. Le Chen, Xiyuan Lu, Jun Li, Jidong Fu, Zhaonian Zhou, Huangtian Yang*. Intermittent hypoxia protects cardiomyocytes against I/R-induced alterations in Ca2+ homeostasis and contraction via the SR and Na+/Ca2+ exchange mechanisms. Am J Physiol Cell Physiol 2006 Apr;290(4):C1221-C1229.
  59. Jidong Fu, Jun Li, David Tweedie, Huimei Yu, Le Chen, Rong Wang, Daniel R. Riordon, Sheryl A. Brugh, Shiqiang Wang, Kenneth R. Boheler, Huangtian Yang*. Crucial role of the sarcoplasmic reticulum in the developmental regulation of Ca2+ transients and contraction in cardiomyocytes derived from embryonic stem cells. FASEB J 2006 Jan;20(1):181-183.
  60. Zhang FB, Li L, Fang B, Zhu DL, Yang HT*, Gao PJ*. Passage-restricted differentiation potential of mesenchymal stem cells into cardiomyocyte-like cells. Biochem Biophys Res Commun 2005 Oct 28;336(3):784-792.
  61. Xie Y, Zhu Y, Zhu WZ, Chen L, Zhou ZN, Yuan WJ, Yang HT*. Role of dual-site phospholamban phosphorylation in intermittent hypoxia-induced cardioprotection against ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 2005 Jun;288(6):H2594-H2602.
  62. Yan Xie, Weizhong Zhu, Zhaonian Zhou, Zhu Yi, Huangtian Yang*. Intermittent high altitude hypoxia protects the heart against lethal Ca2+ overload injury. Life Sci 2004 Dec 17;76(5):559-572.
  63. Anna M. Wobus, K Guan, Huangtian Yang, Kenneth R. Boheler. Embryonic stem cells as a model to study cardiac, skeletal muscle, and vascular smooth muscle cell differentiation. Methods in Molecular Biology 2002;185:127-156.
  64. Huangtian Yang*, David Tweedie, Su Wang, Antonio Guia, Tatiana Vinogradova, Konstantin Bogdanov, Paul D. Allen, Michael D. Stern, Edward G. Lakatta, Kenneth R. Boheler. The ryanodine receptor modulates the spontaneous beating rate of cardiomyocytes during development. Proc Natl Acad Sci USA 2002 Jul 9;99(14):9225-9230.
  65. Huangtian Yang*, Kiyoharu sakurai, Hiromi Sugawara, Tomoo Watanabe, Ikuo Norota, Masao Endoh. Contribution of Na+/Ca2+ exchange to the endothelin-1-induced increases in Ca2+ transient and contractility in rabbit ventricular cardiac myocytes: pharmacological analysis with KB-R7943. Br J Pharmacol 1999 Apr;126(8):1785-1795.
  66. Huangtian Yang, Masao Endoh. Pharmacological evidence for a1D-adrenoceptors in the rabbit ventricular myocardium: analysis with BMY 7378. Br J Pharmacol 1997 Dec;122(8):1541-1550.
  67. Y Zhu, HT Yang, M Endoh. Does nitric oxide contribute to the negative choronotropic and inotropic effects of endothelin-1 in the heart? Eur J Pharmacol 1997 Aug 6;332(2):195-199.
  68. Yi Zhu, Huangtian Yang, Masao Endoh. Negative chronotropic and inotropic effects of endothelin isopeptides in mammalian cardiac muscle. Am J Physiol 1997 Jul;273(1 Pt 2):H119-H127.
  69. Huangtian Yang, Yi Zhu, Masao Endoh. Species-dependent differences in inotropic effects and phosphoinositide hydrolysis induced by endothelin-3 in relation to specific binding sites in mammalian ventricular myocardium. Br J Pharmacol 1997 Apr;120(8):1497-1504.
  70. Huangtian Yang, Masao Endoh. (±)-Tamsulosin, an a1A-adrenoceptor antagonist, inhibits the positive inotropic effect but not the accumulation of inositol phosphates in rabbit heart. Eur J Pharmacol 1996 Oct 3;312(3):281-291.
  71. Huangtian Yang, Ikuo Norota, Yi Zhu, Masao Endoh. Methoxamine-induced inhibition of the positive inotropic effect of endothelin via a1-adrenoceptors in the rabbit heart. Eur J Pharmacol 1996 Jan 18;296(1):47-54.
  72. Huangtian Yang, Ikuo Norota, Yi Zhu, Masao Endoh. Mechanisms for the inhibitory action of methoxamine on the receptor-mediated inotropic response. Heart 1995;27(2):16-19.
  73. Huangtian Yang, Ikuo Norota, Masao Endoh. Positive inotropic effect and acceleration of phosphoinositide hydrolysis by methoxamine. Heart 1994;26(4):24-28.
  74. Yang Huangyian, Yang Yulin. Study of alpha-1 adrenoceptors in heart: mechanisms of positive inotropic effects and receptor subtypes. Chinese Pharmacological Bulletin 1994;10:411-414.
  75. Huangtian Yang and Masao Endoh. Dissociation of the methoxamine-induced positive inotropic effect and phosphoinositide hydrolysis in rabbit ventricular myocardium: comparison with phenylephrine and alpha-1 adrenoceptor subtype involved. J Pharmacol Exp Ther 1994 May;269(2):732-742.
  76. Kohi M, Yang HT, Endoh M. Myocardial a 1A-adrenoceptor subtypes in rabbit: differentiation by a selective antagonist, HV723. Eur J Pharmacol 1993;250:95-101.
  77. Yang Huangtian, Yang Yulin, Peng Sixun, Huang Wenlong. Hypotensive effect of naphthylmethyl isoquinoline. Acta Pharmaceutica Sinica 1990;25(7):551-554.
  78. Yang Huangtian, Yang Yulin. Effect of naphthylmethyl isoquinoline on the isolated guinea pig myocardium. Acta Pharmaceutica Sinica 1990;25(7):485-489.

Invited reviews, comments (# Contributed equally, * Corresponding Author)

  1. Yu M, Lei W, Cao J, Wang L, Ma A, Zhao ZA, Yang HT, Shen Z, Lan F, Cao F, Liang P, Pei X, Xiang AP, Yu J, Zhang Y, Zhang Y, Li Q, Zhou J, Wei J, Peng Y, Zhu H, Liang L, Cao N, Fu B, Hao J*, Zhao T*, Hu S*. Requirements for human cardiomyocytes. Cell Prolif 2021 Oct 27:e13150.
  2. Boheler KR*, Meli AC*, Yang HT*. Special issue on recent progress with hPSC-derived cardiovascular cells for organoids, engineered myocardium, drug discovery, disease models, and therapy. Pflügers Archiv - Eur J Physiol 2021 Jul;473(7):983-988.
  3. Klionsky DJ,...Yang HT...Tong CK. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 2021 Jan;17(1):1-382.
  4. Li Q#, Wang J#, Wu Q, Cao N*, Yang HT*. Perspective on Human Pluripotent Stem Cell-Derived Cardiomyocytes in Heart Disease Modeling and Repair. Stem Cells Transl Med 2020 Jul 29;9(10):1121-1128.
  5. Berry JL, Zhu W, Tang YL, Krishnamurthy P, Ge Y, Cooke JP, Chen Y, Garry DJ, Yang HT, Rajasekaran NS, Koch WJ, Li S, Domae K, Qin G, Cheng K, Kamp TJ, Ye L, Hu S, Ogle BM, Rogers JM, Abel ED, Davis ME, Prabhu SD, Liao R, Pu WT, Wang Y, Ping P, Bursac N, Vunjak-Novakovic G, Wu JC, Bolli R, Menasché P, Zhang J. Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure. Circ Res 2019 Jan 4;124(1):161-169.
  6. Wu Q, Yang HT*. Roles of Exosomes Secreted from Stem Cells and Their Derived Cells in Cardiac Repair Following Myocardial Infarction. Chinese Journal of Cell Biology 中文版本. 2018;40(13):2198-2208.
  7. Xinyang Hu, HuangTian Yang, Yuangui Zhu, Jian'an Wang, Erdan Dong. Chinese Basic Cardiovascular Research in Transition. Circ Res 2016;118(12):1876-1879. (viewpoint)
  8. Yang HT*, Zhang M, Huang JJ, Liang H, Zhang P, Boheler KR. Cardiomyocytes derived from pluripotent stem cells: progress and prospects from China. Exp Cell Res 2013;319(2):120-125.
  9. Feng Y, Wang Y, Cao N, Yang H, Wang Y*. Progenitor/stem cell transplantation for repair of myocardial infarction: Hype or hope? Ann Palliat Med 2012;1(1):65-77.
  10. Yang HT*. Adaptation to Intermittent Hypoxia Protects the Heart from Ischemia/Reperfusion Injury and Myocardial Infarction. Science 2012.P47-48.
  11. Huangtian Yang, Chaoshu Tan. Spotlight on cardioprotection against ischemia-reperfusion injury (Editorial Comment). Acta Physiologica Sinica Special Issue on Cardiovascular Injury and Protection. 2007;59(5):540-541.
  12. Zhang Yi, Yang HT, Zhou ZN. The Cardioprotection of intermittent hypoxic adaptation. Acta Physiologica Sinica 2007;59(5):601-613.
  13. Jidong Fu, Huangtian Yang*. Developmental regulation of intracellular calcium homeostasis in early cardiac myocytes. Acta Physiologica Sinica 2006;58(2):95-103.
  14. Zhang FB, Yang HT*. Plasticity of bone marrow mesenchymal stem cells differentiating into cardiomyocytes and the potential of cardiac therapeutics. Progress in Physiological Sciences 2006;37(3):199-204.
  15. Yang HT. Stem Cells. Science (Chinese) 2005;57(5):54-55.
  16. Yang HT. Stem Cells: Hot Field in life science. Science (Chinese) 2002;54(3):12-14.
  17. KR Boheler, J Czyz, D Tweedie, HT Yang, SV Anisimov, AW Wobus. Differentiation of pluripotent embryonic stem cells into cardiomyocytes. Circ Res 2002;91:189-201.
  18. Endoh M, Maruya J, Norota I, Yang HT, Talukder MA, Hassan, Watanabe T, Sakurai K. Cardiac effects of endothelin: difference between signals in myocytes and intact ventricular myocardium. Current Topics in Pharmacology 1998;4:293-300.
  19. Yang HT, Yang YL. Study of alpha-1 adrenoceptors in heart: mechanisms of positive inotropic effects and receptor subtypes. Chinese Pharmacological Bulletin 1994;10:411-414.

Book chapters

  1. Wu Q, Ke MX, Yang HT*. Charpter 7 in part II. Isolation and characterization of extracellular vesicles secreted from human pluripotent stem cell-derived cardiovascular progenitor cells. Edited by Maurizio Federico and Barbara Ridolfi, Extracellular Vesicles in Diagnosis and Therapy in Methods in Molecular Biology, published by Springer Nature, 2022;2504:91-100.
  2. Nan Cao, He Liang, Huangtian Yang*. Generation, Expansion, and Differentiation of Cardiovascular Progenitor Cells from Human Pluripotent Stem Cells. Edited by Kursad Turksen, Ph.D., Cell-Cell Communications in Stem Cell Renewal: Methods Mol Biol. published by Springer 2015;1212:113-25. doi: 10.1007/7651_2014_119
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