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YANG Huang-Tian


Professor, Principal Investigator

Laboratory of Molecular Cardiology

Email: htyang@@sibs.ac.cn

Research Areas:

The long-term goal of Dr. Yang′s lab is to identify the mechanisms that underlie the physiological and pathological alterations in cardiac contractile function, myocardial ischemia/reperfusion injury and protection, and myocardial repair; and to develop novel targets and therapeutic strategies related to prevention and treatment of ischemic diseases and heart failure. The lab is currently conducting the researches in the following aspects:
1. Identification of regulatory mechanisms underlying cardiomyocyte fate decision of pluripotent stem cells and development of effective cardiac differentiation approaches;
2. Characterization of pluripotent stem cell-derived cardiomyocytes and application in myocardial repair and drug screen;
3. Elucidation of the regulatory mechanisms underlying Ca2+ signaling in cardiogenesis, and protection;
4. Exploration of the new effect and mechanisms of intermittent hypoxic adaptation-, natural compounds- and endogenous factors-induced cardioprotection against ischemic injury and explore their therapeutic significance.


Brief Biography:

1978 - 1982: B.S in Medicine, Nantong Medical College, China
1985 - 1988: M.D in Medicine, Su Zhou Medical College, China
1992 - 1994: Ph.D. in Medicine, Yamagata University, School of Medicine, Japan

Major Academic Appointments
1982 - 1985: Instructor, Nantong Medical College, China
1989 - 1992: Assistant Professor, Nantong Medical College, China
1992 - 1997: Instructor, research fellow, Dept. of Pharmacology, Yamagata University School of Medicine, Japan
1997 - 2001: Researcher fellow, Laboratory of Cardiovascular Science, Gerontology Research Center, NIA, NIH, USA
2000 - 2016 : Principal Investigator, Professor, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine
2003 - 2004: Director Assistant, Institute of Health Sciences, SIBS, CAS/SJTUSM, China
2005 - 2014: Associate Director, Institute of Health Sciences, SIBS, CAS/SJTUSM, China
2017 - Present: Professor, Principal Investigator, Shanghai Institute of Nutrition and Health, CAS


American Heart Association/American Stroke Association Professional Membership
Chinese Association for Physiological Sciences, Circulation Committee (Council member)
Chinese Association of Pathophysiology, Cardiovascular Sciences and Receptor/Signal Transduction Professional Committee (Council member)
Chinese Association of Plastics and Aesthetics Branch of Stem Cell & Application (Executive member
Chinese Medical Association for Cardiovascular Disease Branch (Council member)
Chinese Pharmacological Society for Cardiovascular Pharmacology (member of the standing committee)
Chinese Medical Association for Heart Regeneration (Council member)
Chinese Society of Cardiovascular Pharmacology (Council member)
International Society for Heart Research-China Section (Vice Chairman)
Shanghai Society for Cell Biology (Vice- Chairman)
The International Society for Heart Research (Fellow)


Acta Pharmacol. Sinica
Acta Physiologica Sinica(Editorial Board of the Standing Committee)
AJP-Heart and Circulatory Physiology
Cardiovascular Drugs and Therapy
Cell Death Disease
Chinese Journal of Applied Physiology
Chinese Journal of Molecular Cardiology
Current Opinion in Physiology
Engineering-Tissue Engineering
Frontier in Pharmacology
J Mol Cell Cardiol (Associate Editor)
Pflügers Archiv - European Journal of Physiology (Executive Editor)


Selected Publications:(*Corresponding Author)

  1. Liu YP#, Bai HJ#, Yang CL, Luo XL, Zhang P, Guo FF, Fen XQ, Phung T, Zhu D, Guo J, Liang P, Xu Z, Yang HT*, Lu XY*. PGC-1α Activator ZLN005 Promotes Maturation of Cardiomyocytes Derived from Human Embryonic Stem Cells. Aging. 2020 Apr 28;12(8):7411-7430.
  2. Wu Q#, Wang JX#, Tan WLW, Jiang Y, Wang SH, Li Q, Yu XJ, Tan JL, Liu SY, Zhang P, Tiang Z, Chen ZY, Foo RSY, Yang HT*. Extracellular vesicles from human embryonic stem cell-derived cardiovascular progenitor cells promote cardiac infarct healing through reducing cardiomyocyte death and promoting angiogenesis. Cell Death & Disease. 2020 May 11;11(5):354.
  3. Hu JL#, Liang H#, Zhang H#, Yang MZ#, Sun W, Zhang P, Luo L, Feng JX, Bai HJ, Liu F, Zhang TP, Yang JY, Gao QS, Long YK, Ma XY, Chen Y, Zhong Q, Yu B, Liao S, Wang YB, Zhao Y, Zeng MS, Cao N, Wang JC, Chen W*, Yang HT*, Gao S*. FAM46B is a prokaryote-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells. Nucleic Acids Research. 2020 Mar 18;48(5):2733-2748.
  4. Poon E*, Luo XL, Webb S, Yan B, Zhao R, Wu S, Yang Y, Zhang P, Bai HJ, Shao JF, Chan C, Chan G, Tsang S, Gundry R, Yang HT, Boheler K*. The Cell Surface Marker CD36 Selectively identifies Matured, Mitochondria-rich hPSC-Cardiomyocytes. Cell Res. 2020 Mar 10. doi: 10.1038/s41422-020-0292-y.
  5. Bai H J, Zhang P, Ma L, Liang H, Wei G, Yang HT*. SMYD2 drives mesendodermal differentiation of human embryonic stem cells through mediating the transcriptional activation of key mesendodermal genes. Stem Cells. 2019 Nov;37(11):1401-1415.
  6. Wang X, Wang L, Wu Q, Bao F, Yang HT*, Qiu X*, Chang J*. Chitosan/Calcium Silicate Cardiac Patch Stimulates Cardiomyocyte Activity and Myocardial Performance after Infarction by Synergistic Effect of Bioactive Ions and Aligned Nanostructure. ACS applied materials & interfaces. 2019;11(1):1449-1468.
  7. Wang JX, Liu ML, Wu Q, Li Q, Gao L, Jiang Y, Deng B, Huang W, Bi W, Chen Z, Chin Y, Paul C, Wang Y, Yang HT*. Human Embryonic Stem Cell-Derived Cardiovascular Progenitors Repair Infarcted Hearts through Modulation of Macrophages via Activation of STAT6. Antioxid Redox Signal. 2019 Aug 10;31(5):369-386.
  8. Rusinkevich V, Huang Y, Chen ZY, Qiang W, Wang YG, Shi YF, Yang HT*. Temporal dynamics of immune response following prolonged myocardial ischemia/reperfusion with and without cyclosporine A. Acta Pharmacol Sin. 2019 Sep;40(9):1168-1183.
  9. Fang X, Wang H, Han D, Xie E, Yang X, Wei J, Gu S, Gao F, Zhu N, Yin X, Cheng Q, Zhang P, Dai W, Chen J, Yang F, Yang HT, Linkermann A, Gu W, Min J, Wang F. Ferroptosis as a target for protection against cardiomyopathy. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2672-2680.
  10. Tan JL, Shanshan Gu, Yanjun Zheng, Yang HT. Expression Profile of Circular RNAs in Myocardial Ischemia/Reperfusion with and without Intermittent Hypobaric Hypoxia Preconditioning. Sci China Life Sci. 2019 Aug;62(8):1104-1106.
  11. Huang C, Tu W, Fu Y, Wang J, Xie X. Chemical-induced cardiac reprogramming in vivo. Cell Res. 2018;28(6):686-689.
  12. Zhu K, Wu Q, Ni C, Zhang P, Zhong Z, Wu Y, Wang Y, Xu Y, Kong M, Cheng H, Tao Z, Yang Q, Liang H, Jiang Y, Li Q, Zhao J, Huang J, Zhang F, Chen Q, Li Y, Chen J, Zhu W, Yu H, Zhang J, Yang HT*, Hu X*, Wang J*. Lack of remuscularization following transplantation of human embryonic stem cell-derived cardiovascular progenitor cells in infarcted nonhuman primates. Circ Res. 2018 Mar 30;122(7):958-969.
  13. Wang YJ, Huang J, Liu W, Kou X, Tang H, Wang H, Yu X, Gao S, Ouyang K, Yang HT*. IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway. J Mol Cell Biol. 2017 Aug 1;9(4):274-288. (cover article)
  14. Chen ZY, Chen F, Cao N, Zhou ZW, Yang HT*. miR-142-3p contributes to early cardiac fate decision of embryonic stem cells. Stem Cells Int. 2017;2017:1769298.
  15. Zheng Y, Gu S, Li X, Tan J, Liu S, Jiang Y, Zhang C, Gao L, Yang HT*. Berbamine postconditioning protects the heart from ischemia/reperfusion injury through modulation of autophagy. Cell Death Dis. 2017 Feb 2;8(2):e2577.
  16. Lu J, Kaestle K, Huang J, Liu Q, Zhang P, Gao L, Gardiner J, Thissen H, Yang HT*. Interactions of human embryonic stem cell-derived cardiovascular progenitor cells with immobilized extracellular matrix proteins. J Biomed Mater Res A. 2017 Apr;105(4):1094-1104.
  17. Wang Z, Zhang XJ, Ji YX, Zhang P, Deng KQ, Gong J, Ren S, Wang X, Chen I, Wang H, Gao C, Yokota T, Ang YS, Li S, Cass A, Vondriska TM, Li G, Deb A, Srivastava D, Yang HT, Xiao X, Li H, Wang Y. The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy. Nat Med. 2016;22(10):1131-1139.
  18. Huang J, Zhang M, Zhang P, Liang H, Ouyang K, Yang HT*. Coupling switch of P2Y-IP3 receptors mediates differential Ca2+ signaling in human embryonic stem cells and derived cardiovascular progenitor cells. Purinergic Signal. 2016 Sep;12(3):465-478.
  19. Tang Y, Hong YZ, Bai HJ, Wu Q, Chen CD, Lang JY, Boheler KR, Yang HT*. PHF8 regulates mesodermal and cardiac differentiation of embryonic stem cells through mediating the histone demethylation of pmaip1. Stem Cells. 2016 Jun;34(6):1527-1540.
  20. Wu L, Tan JL, Wang ZH, Chen YX, Gao L, Liu JL, Yun-Hua S, Endoh M, Yang HT*. ROS generated during early reperfusion contribute to intermittent hypobaric hypoxia-afforded cardioprotection against postischemia-induced Ca2+ overload and contractile dysfunction via the JAK2/STAT3 pathway. J Mol Cell Cardiol. 2015 Apr;81:150-161.
  21. Chen YX, Liu JL, Zheng YJ, Wang JX, Wang ZH, Gu SS, Tan JL, Jing Q, Yang HT*. Uncoupling Protein 3 Mediates H2O2 Preconditioning-Afforded Cardioprotection through the Inhibition of MPTP Opening. Cardiovasc Res. 2015 Feb 1;105(2):192-202.
  22. Ling Gao, Yanjun Zheng, Shanshan Gu, Jiliang Tan, Christian Paul, Yigang Wang, Huangtian Yang*. Degradation of cardiac myosin light chain kinase by matrix metalloproteinase-2 contributes to myocardial contractile dysfunction during ischemia/reperfusion. J Mol Cell Cardiol. 2014 Dec;77:102-112.
  23. Wang ZH, Liu JL, Wu L, Yu Z, Yang HT*. Concentration-dependent wrestling between detrimental and protective effects of H2O2 during myocardial ischemia/reperfusion. Cell Death Dis. 2014 Jun 19;5:e1297.
  24. Tang Y, Chen ZY, Hong YZ, Wu Q, Lin HQ, Chen CD, Yang HT*. Expression profiles of histone lysine demethylases during cardiomyocyte differentiation of mouse embryonic stem cells. Acta Pharmacol Sin. 2014 Jul;35(7):899-906.
  25. Gao L, Chen L, Lu ZZ, Gao H, Wu L, Chen YX, Zhang CM, Jiang YK, Jing Q, Zhang Y, Yang HT*. Activation of α1B-adrenoceptors contributes to intermittent hypobaric hypoxia-improved post-ischemic myocardial performance via inhibiting MMP-2 activation. Am J Physiol Heart Circ Physiol. 2014 Jun 1;306(11):H1569-H1581.
  26. Cao N, Liang H, Huang J, Wang J, Chen Y, Chen Z, Yang HT*. Highly efficient induction and long-term maintenance of multipotent cardiovascular progenitors from human pluripotent stem cells under defined conditions. Cell Res. 2013 Sep;23(9):1119-1132.
  27. Zhang CM, Gao L, Zheng YJ, Yang HT*. Berbamine Protects the Heart From Ischemia/Reperfusion Injury by Maintaining Cytosolic Ca2+ Homeostasis and Preventing Calpain Activation. Circ J. 2012;76(8):1993-2002.
  28. Wang ZH, Cai XL, Wu L, Zhuo Y, Liu JL, Zhou ZN, Liu JK, Yang HT*. Mitochondrial Energy Metabolism Plays a Critical Role in the Cardioprotection Afforded by Intermittent Hypobaric Hypoxia. Exp Physiol. 2012 Oct;97(10):1105-1118.
  29. Wang J, Cao N, Yuan M, Cui H, Tang Y, Qin LJ, Huang X, Shen N, Yang HT*. MicroRNA-125b/Lin28 pathway contributes to the mesendodermal fate decision of embryonic stem cells. Stem Cells Dev. 2012 Jun 10;21(9):1524-1537.
  30. Cao N, Liu Z, Chen Z, Wang J, Chen T, Zhao X, Ma Y, Qin L, Kang J, Wei B, Wang L, Jin Y, Yang HT*. Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells through promoting the proliferation of cardiac progenitor cells. Cell Res. 2012 Jan;22(1):219-236.
  31. Wang ZH, Chen YX, Zhang CM, Wu L, Yu Z, Cai XL, Guan Y, Zhou ZN, Yang HT*. Intermittent Hypobaric Hypoxia Improves Post-ischemic Recovery of Myocardial Contractile Function via Redox Signaling during Early Reperfusion. Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1695-H1705.
  32. Zhang CM, Gao L, Zheng YJ, Yang HT*. Berbamine Increases Myocardial Contractility via a Ca2+-independent Mechanism. J Cardiovasc Pharmacol. 2011 Jul;58(1):40-48.
  33. Cao N, Liao J, Liu Z, Zhu W, Wang J, Liu L, Yu L, Xu P, Cui C, Xiao L, Yang HT*. In vitro differentiation of rat embryonic stem cells into functional cardiomyocytes. Cell Res. 2011 Sep;21(9):1316-1331.
  34. Xu WQ, Yu Z, Xie Y, Huang GQ, Shu XH, Zhu Y, Zhou ZN, Yang HT*. Therapeutic effect of intermittent hypobaric hypoxia on myocardial infarction in rats. Basic Res Cardiol. 2011 May;106(3):329-342.
  35. Liang J, Wang YJ, Tang Y, Cao N, Wang J, Yang HT*. Type 3 inositol 1,4,5-trisphosphate receptor negatively regulates apoptosis during mouse embryonic stem cell differentiation. Cell Death Differ. 2010 Jul;17(7):1141-1154.
  36. Yu Z, Wang ZH, Yang HT*. Calcium/calmodulin-dependent protein kinase II mediates cardioprotection of intermittent hypoxia against ischemic-reperfusion-induced cardiac dysfunction. Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H735-H742.
  37. Guo A, Yang HT*. Ca2+ removal mechanisms in mouse embryonic stem cell-derived cardiomyocytes. Am J Physiol Cell Physiol. 2009 Sep;297(3):C732-C741.
  38. Yang WW, Shu B, Zhu Y, Yang HT*. E2F6 Inhibits Cobalt Chloride-Mimetic Hypoxia-induced Apoptosis through E2F1. Mol Biol Cell. 2008 Sep;19(9):3691-3700. (cover article)
  39. Xi-Yuan Lu, Le Chen, Xiao-Long Cai, Huangtian Yang*. Overexpression of heat shock protein 27 against ischemia/reperfusion-induced cardiac contractile dysfunction via stabilization of troponin I and troponin T. Cardiovasc Res. 2008 Aug 1;79(3):500-508.
  40. Hui-Mei Yu, Jing Wen, Rong Wang, Wan-Hua Shen, Shumin Duan, Huangtian Yang*. Critical role of type 2 ryanodine receptor in mediating activing-depent neurogensis from embryonic stem cells. Cell Calcium. 2008 Jun;43:417-431.
  41. Rong Wang, Ji Liang, Lianju Qin and Huangtian Yang*. Promoter-dependent EGFP expressions during embryonic stem cell propagation and differentiation. Stem Cells Dev. 2008 Apr;17(2):279-289.
  42. Shu B, Yang WW, Yang HT*. Expression pattern of E2F6 in physical and chemical hypoxia-induced apoptosis. Sheng Li Xue Bao. 2008 Feb 25;60(1):1-10.
  43. Gao H, Chen L, Yang HT*. Activation of alpha(1B)-adrenoceptors alleviates ischemia/reperfusion injury by limitation of mitochondrial Ca(2+) overload in cardiomyocytes. Cardiovasc Res. 2007 Aug 1;75(3):584-595.
  44. Li J, Zhang H, Zhu WZ, Yu Z, Guo A, Yang HT*, Zhou ZN. Preservation of the pHi during ischemia via PKC by intermittent hypoxia. Biochem Biophys Res Commun. 2007 May 4;356(2):329-333.
  45. Yang WW, Wang ZH, Zhu Y, Yang HT*. E2F6 negatively regulates ultraviolet-induced apoptosis via modulation of BRCA1. Cell Death Differ. 2007 Apr;14(4):807-817.
  46. Jidong Fu, Huimei Yu, Rong Wang, Ji Liang, Huangtian Yang*. Developmental regulation of intracellular calcium transients during cardiomyocyte differentiation of mouse embryonic stem cells. Acta Pharmacol Sin. 2006 Jul;27(7):901-910.
  47. Le Chen, Xi-Yuan Lu, Jun Li, Ji-Dong Fu, Zhao-Nian Zhou, Huangtian Yang*. Intermittent hypoxia protects cardiomyocytes against I/R-induced alterations in Ca2+ homeostasis and contraction via the SR and Na+/Ca2+ exchange mechanisms. Am J Physiol Cell Physiol. 2006 Apr;290(4):C1221-C1229.
  48. Jidong Fu, Jun Li, David Tweedie, Huimei Yu, Le Chen, Rong Wang, Daniel R. Riordon, Sheryl A. Brugh, Shiqiang Wang, Kenneth R. Boheler, Huangtian Yang*. Crucial role of the sarcoplasmic reticulum in the developmental regulation of Ca2+ transients and contraction in cardiomyocytes derived from embryonic stem cells. FASEB J. 2006 Jan;20(1):181-183.
  49. Zhang FB, Li L, Fang B, Zhu DL, Yang HT*, Gao PJ*. Passage-restricted differentiation potential of mesenchymal stem cells into cardiomyocyte-like cells. Biochem Biophys Res Commun. 2005 Oct 28;336(3):784-792.
  50. Xie Y, Zhu Y, Zhu WZ, Chen L, Zhou ZN, Yuan WJ, Yang HT*. Role of dual-site phospholamban phosphorylation in intermittent hypoxia-induced cardioprotection against ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2005 Jun;288(6):H2594-H2602.
  51. Yan Xie, Weizhong Zhu, Zhaonian Zhou, Zhu Yi, Huangtian Yang*. Intermittent high altitude hypoxia protects the heart against lethal Ca2+ overload injury. Life Sci. 2004 Dec 17;76(5):559-572.
  52. Anna M. Wobus, K Guan, Huangtian Yang, Kenneth R. Boheler. Embryonic stem cells as a model to study cardiac, skeletal muscle, and vascular smooth muscle cell differentiation. Methods in Molecular Biology. 2002;185:127-156.
  53. Huangtian Yang*, David Tweedie, Su Wang, Antonio Guia, Tatiana Vinogradova, Konstantin Bogdanov, Paul D. Allen, Michael D. Stern, Edward G. Lakatta and Kenneth R. Boheler. The ryanodine receptor modulates the spontaneous beating rate of cardiomyocytes during development. Proc Natl Acad Sci USA. 2002;99:9225-9230.
  54. Huangtian Yang*, Kiyoharu sakurai, Hiromi Sugawara, Tomoo Watanabe, Ikuo Norota, Masao Endoh. Contribution of Na+/Ca2+ exchange to the endothelin-1-induced increases in Ca2+ transient and contractility in rabbit ventricular cardiac myocytes: pharmacological analysis with KB-R7943. Br J Pharmacol. 1999;126:1785-1795.
  55. Y Zhu, HT Yang, M Endoh. Does nitric oxide contribute to the negative choronotropic and inotropic effects of endothelin-1 in the heart? Eur J Pharmacol. 1997;332:195-199.
  56. Huangtian Yang, Masao Endoh. Pharmacological evidence for a1D-adrenoceptors in the rabbit ventricular myocardium: analysis with BMY 7378. Br J Pharmacol. 1997;122:1541-1550.
  57. Yi Zhu, Huangtian Yang and Masao Endoh. Negative chronotropic and inotropic effects of endothelin isopeptides in mammalian cardiac muscle. Am J Physiol. 1997;273(42):H119-H127.
  58. Huangtian Yang, Yi Zhu and Masao Endoh. Species-dependent differences in inotropic effects and phosphoinositide hydrolysis induced by endothelin-3 in relation to specific binding sites in mammalian ventricular myocardium. Br J Pharmacol. 1997;120:1497-1504.
  59. Huangtian Yang, Masao Endoh. (±)-Tamsulosin, an a1A-adrenoceptor antagonist, inhibits the positive inotropic effect but not the accumulation of inositol phosphates in rabbit heart. Eur J Pharmacol. 1996;312(3):281-291.
  60. Huangtian Yang, Ikuo Norota, Yi Zhu and Masao Endoh. Methoxamine-induced inhibition of the positive inotropic effect of endothelin via a1-adrenoceptors in the rabbit heart. Eur J Pharmacol. 1996;296(1):47-54.
  61. Huangtian Yang, Ikuo Norota, Yi Zhu and Masao Endoh. Mechanisms for the inhibitory action of methoxamine on the receptor-mediated inotropic response. Heart. 1995;27(2):16-19.
  62. Huangtian Yang, Ikuo Norota and Masao Endoh. Positive inotropic effect and acceleration of phosphoinositide hydrolysis by methoxamine. Heart. 1994;26(4):24-28.
  63. Yang Huangyian, Yang Yu-Lin. Study of alpha-1 adrenoceptors in heart: mechanisms of positive inotropic effects and receptor subtypes. Chinese Pharmacological Bulletin. 1994;10:411-414.
  64. Huangtian Yang and Masao Endoh. Dissociation of the methoxamine-induced positive inotropic effect and phosphoinositide hydrolysis in rabbit ventricular myocardium: comparison with phenylephrine and alpha-1 adrenoceptor subtype involved. J Pharmacol Exp Ther. 1994;269(2):732-742.
  65. Kohi M, Yang HT, Endoh M. Myocardial a 1A-adrenoceptor subtypes in rabbit: differentiation by a selective antagonist, HV723. Eur J Pharmacol. 1993;250:95-101.
  66. Yang Huangtian, Yang Yulin, Peng Sixun, Huang Wenlong. Hypotensive effect of naphthylmethyl isoquinoline. Acta Pharmaceutica Sinica. 1990;25(7):551-554.
  67. Yang Huangtian, Yang Yulin. Effect of naphthylmethyl isoquinoline on the isolated guinea pig myocardium. Acta Pharmaceutica Sinica. 1990;25(7):485-489.

Invited reviews, comments

  1. Berry JL, Zhu W, Tang YL, Krishnamurthy P, Ge Y, Cooke JP, Chen Y, Garry DJ, Yang HT, Rajasekaran NS, Koch WJ, Li S, Domae K, Qin G, Cheng K, Kamp TJ, Ye L, Hu S, Ogle BM, Rogers JM, Abel ED, Davis ME, Prabhu SD, Liao R, Pu WT, Wang Y, Ping P, Bursac N, Vunjak-Novakovic G, Wu JC, Bolli R, Menasché P, Zhang J. Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure. Circ Res. 2019 Jan 4;124(1):161-169. doi: 10.1161/CIRCRESAHA.118.314216.
  2. Wu Q, Yang HT*. Roles of Exosomes Secreted from Stem Cells and Their Derived Cells in Cardiac Repair Following Myocardial Infarction. Chinese Journal of Cell Biology 中文版本. 2018;40(13):2198-2208. doi: 10.11844/cjcb.2018.13.0008.
  3. Xinyang Hu, HuangTian Yang, Yuangui Zhu, Jian'an Wang, Erdan Dong. Chinese Basic Cardiovascular Research in Transition. Circ Res. 2016;118(12):1876-1879. doi: 10.1161/CIRCRESAHA.116.308063. (viewpoint)
  4. Yang HT*, Zhang M, Huang JJ, Liang H, Zhang P, Boheler KR. Cardiomyocytes derived from pluripotent stem cells: progress and prospects from China. Exp Cell Res. 2013;319(2):120-125. doi: 10.1016/j.yexcr.2012.09.011.
  5. Feng Y, Wang Y, Cao N, Yang H, Wang Y*. Progenitor/stem cell transplantation for repair of myocardial infarction: Hype or hope? Ann Palliat Med. 2012;1(1):65-77.
  6. Yang HT*. Adaptation to Intermittent Hypoxia Protects the Heart from Ischemia/Reperfusion Injury and Myocardial Infarction. Science 2012.P47-48.
  7. Huang-Tian Yang and Chao-Shu TAN. Spotlight on cardioprotection against ischemia-reperfusion injury (Editorial Comment). Acta Physiologica Sinica Special Issue on Cardiovascular Injury and Protection. 2007;59(5):540-541.
  8. Zhang Yi, Yang HT, Zhou ZN. The Cardioprotection of intermittent hypoxic adaptation. Acta Physiologica Sinica. 2007;59(5):601-613.
  9. Ji-Dong Fu, Huang-Tian Yang*. Developmental regulation of intracellular calcium homeostasis in early cardiac myocytes. Acta Physiologica Sinica, 2006;58(2):95-103.
  10. Zhang FB, Yang HT*. Plasticity of bone marrow mesenchymal stem cells differentiating into cardiomyocytes and the potential of cardiac therapeutics. Progress in Physiological Sciences. 2006;37(3):199-204.
  11. Yang HT. Stem Cells. Science (Chinese) 2005;57(5):54-55.
  12. Yang HT. Stem Cells: Hot Field in life science. Science (Chinese) 2002;54(3):12-14.
  13. KR Boheler, J Czyz, D Tweedie, Huang-Tian Yang, Anisimov SV, Wobus AW. Differentiation of pluripotent embryonic stem cells into cardiomyocytes. Circ Res, 2002;91:189-201.
  14. Endoh M, Maruya J, Norota I, Yang HT, Talukder M A, Hassan, Watanabe T, Sakurai K. Cardiac effects of endothelin: difference between signals in myocytes and intact ventricular myocardium. Current Topics in Pharmacology. 1998;4:293-300.
  15. Yang Huang-Tian, Yang Yu-Lin. Study of alpha-1 adrenoceptors in heart: mechanisms of positive inotropic effects and receptor subtypes. Chinese Pharmacological Bulletin. 1994;10:411-414.

Book chapters

  1. Nan Cao, He Liang, Huang-TianYang*. Generation, Expansion, and Differentiation of Cardiovascular Progenitor Cells from Human Pluripotent Stem Cells. Edited by Kursad Turksen, Ph.D., Cell-Cell Communications in Stem Cell Renewal: Methods Mol Biol. published by Springer 2015;1212:113-25. doi: 10.1007/7651_2014_119.
  2. Yang HT*, Yi Zhang, Wang ZH and Zhou ZN. Chapter 4. Protective effects of chronic intermittent hypoxia against myocardial ischemia/reperfusion injury, p47-58 in the book Intermittent hypoxia and human diseases, Edited by Dr. Lei Xi and Dr. Tatiana V. Serebrovskaya, published by Springer (http://www.springerlink.com/content/978-1-4471-2905-9/?MUD=MP) in 2012.
  3. Huangtian Yang*, Zhaonian Zhou, Le Chen. Effects and mechanism of hypoxia on cardiovascular function. P416-424. In Cardiovascular Physiology: Basic Science and Clinical Relevance. High Education Press, China, 2010.
  4. Yang WW, Wang ZH, Zhu Y, Yang HT*. Biological roles and regulatory mechanisms of transcription factor E2F6 in Control of Celluar Phyiology by E2F Transcription Factors. Edited by Dr. Kenichi Yoshida, Research Signpost. 2008
  5. Huang-Tian Yang*, Yan Xie, Wei-Zhong Zhu, Yi Zhu, Le Chen, Zhao-Nian Zhou. Intermittent high altitude hypoxia protects the heart against lethal Ca2+ overload injury. In Ge Ri-Li and Peter Hackett 《Life On The QingHai-Tibetan Plateau》. P312-317, Peking University Medical Press, 2007
  6. Huang-Tian Yang*, Le Chen, Zhao-Nian Zhou. Researches of the intermittent hypoxia in prevention and treatment of ischemic heart diseases. In Weifeng Shen ed.: Frontier in Cardiology. People′s Military Medical Press, 2007.
  7. Huangtian Yang*, Zhaonian Zhou, Le Chen. Effects and mechanism of hypoxia on cardiovascular function. In Cardiovascular Physiology: Basic Science and Clinical Relevance. High Education Press, China, 2004.
  8. Anna M Wobus, Guan K, Huang-Tian Yang, Kenneth R Boheler. Embryonic stem cells as a model to study cardiac, skeletal muscle, and vascular smooth muscle cell differentiation. In Turksen K ed.: Embryonic Stem Cells: Method and Protocols. Series: Methods in Molecular Biology, Vol.185: 127-156, Humana Press Inc., Totowa, New ersey, 2002