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XIAO Yichuan

Ph.D.

Professor, Principal Investigator

Laboratory of Inflammation and Molecular Immunology

Email: ycxiao@sinh.ac.cn

Tel: 86-21-54923276

Research Areas:

Post-translational modifications (PTM) are enzymatic reactions that adding functional group to the substrate during or after protein biosynthesis. These modifications, such as ubiquitination, phosphorylation, etc., play important roles in the regulation of immune cell function by modulating the protein degradation, trafficking, activation and protein-protein interaction. Therefore, identifying and understanding the molecular mechanisms that regulate PTMs is critical in the study of immune activation and related disease treatment and prevention. Taking advantage of genetic mutant mice and related disease models as well as clinical patient samples, our lab mainly focus on studying the function of the dynamic modulation of PTM in:

1. Immune cell activation and related inflammatory and autoimmune diseases

2. Anti-tumor immunity and its molecular mechanism

3. Neuro-inflammation and its pathological and molecular mechanism

Brief Biography:

2017 - Present Professor, Principal Investigator, Shanghai Institute of Nutrition and Health, CAS

2015 - 2016 Professor, Principal Investigator, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine

2010 - 2015 Postdoctoral Fellow, MD Anderson Cancer Center, Houston, USA

2007 - 2010 Ph.D., Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

2006 - 2007 Scientific Editor, Acta Biochimica et Biophysica Sinica, Shanghai, China

2003 - 2006 M.S., East China University of Science & Technology, Shanghai, China

1999 - 2003 B.S., Hubei University, Wuhan, China

Selected Publications: (*Corresponding Author)

  1. Wang Y, Fu Z, Li X, Liang Y, Pei S, Hao S, Zhu Q, Yu T, Pei Y, Yuan J, Ye J, Fu J, Xu J, Hong J, Yang R, Hou H, Huang X, Peng C, Zheng M*, Xiao Y*. Cytoplasmic DNA sensing by KU complex in aged CD4+ T cell potentiates T cell activation and aging-related autoimmune inflammation. Immunity 2021 Mar 4. doi: 10.1016/j.immuni.2021.02.003.
  2. Pei S, Huang M, Huang J, Zhu X, Wang H, Romano S, Deng X, Wang Y, Luo Y, Hao S, Xu J, Yu T, Zhu Q, Yuan J, Shen K, Liu Z, Hu G, Peng C, Luo Q*, Wen Z*, Dai D*, Xiao Y*. BFAR coordinates TGFβ signaling to modulate Th9-mediated cancer immunotherapy. J Exp Med 2021, In press. doi: 10.1084/jem.20202144
  3. Huang X#*, Hao S#, Liu J#, Huang Y, Liu M, Xiao C, Wang Y, Pei S, Yu T, Xu J, Wang H, Dai D*, Su X*, Xiao Y*. The ubiquitin ligase Peli1 inhibits ICOS and thereby Tfh-mediated immunity. Cell Mol Immunol 2021 Mar 11. doi: 10.1038/s41423-021-00660-5
  4. Xu J#, Yu T#, Pietronigro EC, Yuan J, Arioli J, Pei Y, Luo X, Ye J, Constantin G, Mao C*, Xiao Y*. Peli1 impairs microglial Aβ phagocytosis through promoting C/EBPβ degradation. PLoS Biol 2020 Oct 5;18(10):e3000837
  5. Zhu Q, Yu T, Gan S, Wang Y, Pei Y, Zhao Q, Pei S, Hao S, Yuan J, Xu J, Hou F, Wu X, Peng C, Wu P, Qin J, Xiao Y*. TRIM24 facilitates antiviral immunity through mediating K63-linked TRAF3 ubiquitination. J Exp Med 2020 Jul 6;217(7):e20192083.
    (Recommended by Faculty Opinion)
  6. Yu T#, Gan S#, Zhu Q#, Dai D, Li N, Wang H, Chen X, Hou D, Wang Y, Pan Q, Xu J, Zhang X, Liu J, Pei S, Peng C, Wu P, Romano S, Mao C, Huang M, Zhu X, Shen K, Qin J*, Xiao Y*. Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24. Nat Commun 2019 Sep 25;10(1):4353
  7. Xu J, Pei S, Wang Y, Liu J, Qian Y, Huang M*, Zhang Y*, Xiao Y*. Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells. Front Immunol 2019 Aug 20;10:1980
  8. Zhang X, Wang Y, Yuan J, Li N, Pei S, Xu J, Luo X, Mao C, Liu J, Yu T, Gan S, Zheng Q, Liang Y, Guo W, Qiu J, Constantin G, Jin J, Qin J*, Xiao Y*. Macrophage/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3. J Exp Med 2018 May 7;215(5):1365-1382
    (Selected and highlighted in J Exp Med 2018;215(5):1269–1271)
  9. Liu J, Huang X, Hao S, Wang Y, Liu M, Xu J, Zhang X, Yu T, Gan S, Dai D, Luo X, Lu Q, Mao C, Zhang Y, Shen N, Li B, Huang M, Zhu X, Jin J, Cheng X, Sun SC, Xiao Y*. Peli1 negatively regulate noncanonical NF-κB signaling to restrain systemic lupus erythematosus. Nat Commun 2018 Mar 19;9(1):1136
  10. Xiao Y#, Zou Q#, Xie X#, Liu T, Li HS, Jie Z, Jin J, Hu H, Manyam G, Zhang L, Cheng X, Wang H, Marie I, Levy DE, Watowich SS, Sun SC*. The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity. J Exp Med 2017 May 1;214(5):1493-1507 (# Equal contribution)
  11. Xiao Y, Jin J, Chang M, Nakaya M, Hu H, Zou Q, Zhou X, Brittain GC, Cheng X, Sun SC*. TPL2 mediates autoimmune inflammation through activation of the TAK1 axis of IL-17 signaling. J Exp Med 2014 Jul 28;211(8):1689-1702
  12. Xiao Y, Jin J, Chang M, Chang JH, Hu H, Zhou X, Brittain GC, Stansberg C, Torkildsen ？, Wang X, Brink R, Cheng X, Sun SC. Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation. Nat Med 2013 May;19(5):595-602
    (News and Views in Nat Med 2013;19:536-538. Research highlighted in Nat Immunol 2013;14:535. doi:10.1038/ni.2628)