Research Areas:
1. Risk assessment on co-occurring Fusarium mycotoxin contaminants originated from mycotoxin-producing fungal isolates in foods, via the normal human cells (gastrointestinal, kidney and liver) and target animals (pig, broiler chicken) models.
2. Elucidation of contamination patterns, regulatory and control mechanisms of mycotoxin production in foods, as well as novel nano-materials and natural anti-toxic strains via confrontation for neutralization, detoxification, and early-stage inhibition, of mycotoxins contamination.
3. Establishment and validation of chromatographic approaches (LC-MS/MS) and immunological rapid assays for multi-component mycotoxins in a variety of food matrices.

Brief Biography:
I. Education
1999-2004: Ph.D. Molecular Plant Pathology, Huazhong Agricultural University, Wuhan, China.
1995-1999: B.S. Plant Science, Huazhong Agricultural University, Wuhan, China.
II. Professional Experience
2017-present: Professor, Principal Investigator, Shanghai Institute of Nutrition and Health (SINH), CAS
2015-2016: Professor and Principal Investigator, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
2013-2015: Professor, Institute for Agri-food Standards and Testing Technology, Shanghai Academy of Agricultural Sciences, Shanghai, China.
2011-2012: Associate Professor, Institute for Agri-food Standards and Testing Technology, Shanghai Academy of Agricultural Sciences, Shanghai, China.
2007-2010: Associate Professor, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
2009/2010/2011 one month/per year, Visiting scientist Ghent University, Université Catholique de Louvain, Belgium.
2005-2007: Assistant Professor, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.

Selected Publications: (*Corresponding Author）

1. Zhang DC#, Xing HD#, Liu DL#, Han MY, Cai PL, Lin HK, Tian Y, Guo YH, Sun B, Le YY, Tian Y*, Wu AB*, Hu QN*. Discovery of Toxin-Degrading Enzymes with Positive Unlabeled Deep Learning. ACS Catalysis 2024;14:3336–3348.
2. Jia BX, Lin HK, Yu S, Liu N, Yu DZ, Wu AB*. Mycotoxin deoxynivalenol-induced intestinal flora disorders, dysfunction and organ damage in broilers and pigs. Journal of Hazardous Materials 2023 Mar 7;451:131172.
3. Lin HK, Jia BX, Wu AB*. Cytotoxicities of Co-occurring alternariol, alternariol monomethyl ether and tenuazonic acid on human gastric epithelial cells. Food and Chemical Toxicology 2023 Jan;171:113524.
4. Tian Y, Abdallah M. F, De Boevre M, Audenaert K, Wang C, De Saeger S, Wu AB*. Deciphering Alternaria metabolic responses in microbial confrontation via an integrated mass spectrometric targeted and non-targeted strategy. Food Chemistry 2022 Oct 20;404(Pt B):134694.
5. Sun F, Yu DZ, Zhou HY, Lin HK, Yan Z, Wu AB*. CotA laccase from Bacillus licheniformis ZOM-1 effectively degrades zearalenone, aflatoxin B1 and alternariol. Food Control 2022 Oct 145;ISSN 0956-7135.
6. Zhou HY, Sun F, Lin HK, Fan YY, Wang C, Yu DZ, Liu N, Wu AB*. Food bioactive compounds with prevention functionalities against fungi and mycotoxins: developments and challenges. Current Opinion in Food Science 2022;48:100916, S2214-7993(22)00118-7.
7. Wang L, Yan Z, Zhao QY, Liu N, Yu DZ, Jia BX, Li KL, Gao Y, Wu AB*. A prospective study of total urinary deoxynivalenol in adolescents in Shanghai, China. Chemosphere 2022 Jul 18:135727.
8. Li KL, Yu DZ, Yan Z, Liu N, Fan YY, Wang C, Wu AB*. Exploration of Mycotoxin Accumulation and Transcriptomesof Different Wheat Cultivars duringFusarium graminearum Infection. Toxins 2022 Jul 13;14(7):482.
9. Wang JH, Lin SH, Zhu GH, Zhao ZY, Wang HY, Zhou MP, Zhao XM, Wu AB*. Identification of Candidate Genes Associated with Trichothecene Biosynthesis in Fusarium graminearum Species Complex Combined with Transcriptomic and Proteomic Analysis. Microorganisms 2022 Jul 22;10(8):1479.
10. Tian Y, Zhang DC, Cai PL, Lin HK, Ying H, Hu QN*, Wu AB*. Elimination of Fusarium mycotoxin deoxynivalenol (DON) via microbial and enzymatic strategies: current status and future perspectives. Trends in Food Science and Technology 2022 Jun;124:96-107.
11. Sun F, Cao XQ, Yu DZ, Hu DQ, Yan Z, Fan YY, Wang C, Wu AB*. AaTAS1 and AaMFS1 genes for biosynthesis or efflux transport of tenuazonic acid and pathogenicity of Alternaria alternata. Molecular Plant-Microbe Interactions 2022 May;35(5):416-427.
12. Li KL, Wang L, Yu DZ, Yan Z, Liu N, Wu AB*. Cellobiose inhibits the release of deoxynivalenol from transformed deoxynivalenol-3-glucoside from Lactiplantibacillus plantarum. Food Chemistry: Molecular Sciences 2022 Jan 20;4:100077.
13. Yu S, Jia BX, Lin HK, Zhang S, Yu DZ, Liu N, Wu AB*. Effects of Fumonisin B and Hydrolyzed Fumonisin B on Growth and Intestinal Microbiota in Broilers. Toxins 2022 Mar;14(3):163.
14. Li KL, Yu S, Yu DZ, Lin HK, Liu N, Wu AB*. Biodegradation of fumonisins by the consecutive action of a fusion enzyme. Toxins 2022 Apr;14(4):266.
15. Jia BX, Yu S, Yu, DZ, Liu N, Zhang S, Wu AB*. Mycotoxin deoxynivalenol affects myoblast differentiation via downregulating cytoskeleton and ECM-integrin-FAK-RAC-PAK signaling pathway. Ecotoxicology and Environmental Safety 2021 Oct 1;226:112850.
16. Wang L, Yan Z, Zhou HY, Fan YY, Wang C, Zhang JB, Liao YC, Wu AB*. Validation of LC-MS/MS Coupled with a Chiral Column for the Determination of 3- or 15-Acetyl Deoxynivalenol Mycotoxins from Fusarium graminearum in Wheat. Toxins 2021 Sep 16;13(9):659.
17. Yu S, Jia BX, Liu N, Yu DZ, Zhang S, Wu AB*. Fumonisin B1 triggers carcinogenesis via HDAC/PI3K/Akt signaling pathway in human esophageal epithelial cells. Science of the Total Environmental 2021 Sep 15;787:147405.
18. Zhang DC, Tian Y, Tian Y, Xing HD, Liu S, Zhang HY, Ding SZ, Cai PL, Sun DD, Zhang T, Hong YH, Dai HK, Tu WZ, Chen JN, Wu AB*, Hu QN*. A data-driven integrative platform for computational prediction of toxin biotransformation with a case study. Journal of Hazardous Materials 2021 Apr 15;408:124810.
19. Zhou HY, Liu N, Yan Z, Yu DZ, Wang L, Wang KB, Wei XL, Wu AB*. Development and Validation of the One-step Purification Method Coupled to LC-MS/MS for Simultaneous Determination of Four Aflatoxins in Fermented Tea. Food Chemistry 2021 Aug 30;354:129497.
20. Tian Y, Yu DZ, Liu N, Tang Y, Yan Z, Wu AB*. Confrontation assays and mycotoxin treatment reveal antagonistic activities of Trichoderma and the fate of Fusarium mycotoxins in microbial interaction. Environmental Pollution 2020 Dec;267:115559.
21. Yu S, Jia BX, Liu N, Yu DZ and Wu AB*. Evaluation of the Individual and Combined Toxicity of Fumonisin Mycotoxins in Human Gastric Epithelial Cells. International Journal of Molecular Sciences 2020 Aug 18;21(16):E5917.
22. Yu S, Jia BX, Li KL, Zhou HY, Lai WS, Tang Y, Yan Z, Sun W, Liu N, Yu DZ, Wu AB*. Pre-warning of abiotic factors in maize required for potential contamination of fusarium mycotoxins via response surface analysis. Food Control 2020 Mar 21;121:107570.
23. Yang YX, Yu S, Jia BX, Liu N, Wu AB*. Metabolomic profiling reveals similar cytotoxic effects and protective functions of quercetin during deoxynivalenol- and 15-acetyl deoxynivalenol-induced cell apoptosis. Toxicology in Vitro 2020 Aug;66:104838.
24. Yang XL, Zhao ZY, Tan YL, Chen B, Zhou CY, Wu AB*. Risk profiling of exposures to multiclass contaminants through cereals and cereal-based products consumption: A case study for the inhabitants in Shanghai, China. Food Control 2020 Mar;109:106964.
25. Yu S, Jia BX, Yang YX, Liu N, Wu AB*. Involvement of PERK-CHOP pathway in fumonisin B1- induced cytotoxicity in human gastric epithelial cells. Food and Chemical Toxicology 2020 Feb;136:111080.
26. Wang JH, Wang SX, Zhao ZY, Lin SH, Francois VH, Wu AB*. Species Composition and Toxigenic Potential of Fusarium Isolates Causing Fruit Rot of Sweet Pepper in China. Toxins 2019 Nov 24;11(12):690.
27. Hu DQ, Yu S, Yu DZ, Liu N, Tang Y, Fan YY, Wang C, Wu AB*. Biogenic Trichoderma harzianum-derived selenium nanoparticles with control functionalities originating from diverse recognition metabolites against phytopathogens and mycotoxins. Food Control 2019 Dec;106:106748.
28. Md Shofiul Azam, Yu DZ, Liu N, Wu AB*. Degrading Ochratoxin A and Zearalenone Mycotoxins Using a Multifunctional Recombinant Enzyme. Toxins 2019 May 27;11(5):301.
29. Wang L, Zhang QY, Yan Zheng, Tan YL, Zhu RY, Yu DZ, Yang H*, Wu AB*. Occurrence and Quantitative Risk Assessment of Twelve Mycotoxins in Eggs and Chicken Tissues in China. Toxins 2018 Nov 16;10(11):477.
30. Yang YX, Yu S, Liu N, Xu HB, Gong YY, Wu YN, Wang PL, Su XO, Liao YC, Sarah De Saeger S, Humpf H, Wu AB*. Transcription factor FOXO3a is a negative regulator of cytotoxicity of Fusarium mycotoxin in GES-1 cells. Toxicological Sciences 2018 Dec 1;166(2):370-381.
31. Yan Z, Wang L, Wang J, Tan YL, Yu DZ, Chang XJ, Fan YY, Zhao DY, Wang C, De Boevre M, De Saeger Sarah, Sun CP*, Wu AB*. A QuEChERS-Based Liquid Chromatography-Tandem Mass Spectrometry Method for the Simultaneous Determination of Nine Zearalenone-Like Mycotoxins in Pigs. Toxins 2018 Mar 20;10(3):129.
32. Tian Y, Tan YL, Yan Z, Liao YC, Chen J, Marthe De Boevre, Sarah De Saeger, Aibo Wu*. Antagonistic and Detoxification Potentials of Trichoderma Isolates for Control of Zearalenone (ZEN) Producing Fusarium graminearum. Frontiers in Microbiology 2018 Jan 18;8:2710.
33. Hu DQ, Fan YY, Tan YL, Tian Y, Liu N, Wang L, Zhao DY, Wang C*, Wu AB*. Metabolic Profiling on Alternaria Toxins and Components of Xinjiang Jujubes Incubated with Pathogenic Alternaria alternata and Alternaria tenuissima via Orbitrap High-Resolution Mass Spectrometry. Journal of Agricultural and Food Chemistry 2017 Sep 27;65(38):8466-8474.
34. Yang YX, Yu S, Tan YL, Liu N, Wu AB*. Individual and Combined Cytotoxic Effects of Co-Occurring Deoxynivalenol Family Mycotoxins on Human Gastric Epithelial Cells. Toxins 2017 Mar 9;9(3):96.
35. Liu N, Nie DX, Tan YL, Zhao ZY, Liao YC, Wang H, Saeger SD, Wu AB*. An ultrasensitive amperometric immunosensor for zearalenones based on oriented antibody immobilization on a glassy carbon electrode modified with MWCNTs and AuPt nanoparticles. Microchimica Acta 2017 Jan;184(1):147-153.
36. Shi W, Tan YL, Wang SX, Gardiner D, Saeger SD, Liao YC, Wang C, Fan YY, Wang ZP*, Wu AB*. Mycotoxigenic Potentials of Fusarium Species in Various Culture Matrices Revealed by Mycotoxin Profiling. Toxins 2016 Dec 26;9(1):6.
37. Tian Y, Tan YL, Liu N, Yan Y, Liao YC, Chen J, Saeger SD, Yang H, Zhang QY, Wu AB*. Detoxification of Deoxynivalenol via Glycosylation Represents Novel Insights on Antagonistic Activities of Trichoderma when Confronted withFusarium graminearum. Toxins 2016 Nov 15;8(11):335.
38. Tian Y, Tan YL, Liao YC, Sun CP, Wang SX, Wu AB*. Functional agents to biologically control deoxynivalenol contamination in cereal grains. Frontiers in Microbiology 2016 Mar 30;7:395.
39. Liu N, Zhao ZY, Tan YL, Lu L, Wang L, Liao YC, Natalia B, Saeger SD, Zheng XD*, Wu AB*. Simultaneous raising of rabbit monoclonal antibodies to fluoroquinolones with diverse recognition functionalities via single mixture immunization. Analytical Chemistry 2016 Jan 19;88(2):1246-1252.
40. Zhao ZY, Liu N, Yang LC, Wang JH, Song SQ, Nie DX, Yang XL, Hou JF, Wu AB*. Cross-linked chitosan polymers as generic adsorbents for simultaneous adsorption of multiple mycotoxins. Food Control 2015 Nov;57:362-369.
41. Liu N, Nie DX, Zhao ZY, Meng XJ, Wu AB*. Ultrasensitive immunoassays based on biotin–streptavidin amplified system for quantitative determination of family zearalenones. Food Control 2015 Nov;57:202-209.
42. Sun WS, Han Z, Johan A, Nie DX, Jin MT, Shi W, Zhao ZY, Saeger SD, Zhao Y*, Wu AB*. A reliable liquid chromatography–tandem mass spectrometry method for simultaneous determination of multiple mycotoxins in fresh fish and dried seafoods. Journal of Chromatography A 2015 Mar 27;1387:42-48.
43. Song SQ, Liu N, Zhao ZY, Ediage E.M, Wu SL, Sun CP, Saeger SD, Wu AB*. Multiplex Lateral Flow Immunoassay for Mycotoxin Determination. Analytical Chemistry 2014 May 20;86(10):4995-5001.