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WEI Gang


Professor, Principal Investigator

Laboratory of Epigenome Biology

Lab Page Link: http://www.picb.ac.cn/epigenome/

Email: weigang@picb.ac.cn

Tel: 86-21-54920557

Research Areas:

Epigenetic regulation in cell fate determination

Epigenetic regulation in diseases

Dynamic change and regulatory function of higher-order chromatin structure


Brief Biography:

2012-present Professor, Principal Investigator, CAS-MPG Partner Institute for Computational Biology, China.

2005-2011 Postdoc at National Institutes of Health, Bethesda, MD, USA

2000-2005 PhD in Biochemistry and Molecular Biology at Peking University, Beijing, China

1996-2000 BS in Biochemistry and Molecular Biology at Peking University, Beijing, China


Selected Publications: (*Corresponding Author)

  1. Wang X, Yan J, Shen B*, Wei G*. Integrated chromatin accessibility and transcriptome landscapes of doxorubicin-resistant breast cancer cells. Front Cell Dev Biol 2021 Jul 30;9:708066
  2. Lu B, Liu M, Gu L, Li Y, Shen S, Guo G, Wang F, He X, Zhao Y, Shang X, Wang L, Yang G, Zhu Q, Cao J, Jiang C, Culleton R, Wei G*, Zhang Q*. The Architectural Factor HMGB1 Is Involved in Genome Organization in the Human Malaria Parasite Plasmodium falciparum. mBio 2021 Apr 27;12(2):e00148-21
  3. Lai Y, Cao X, Chen J, Wang L, Wei G*, Wang S*. Coordinated regulation of infection-related morphogenesis by the KMT2-Cre1-Hyd4 regulatory pathway to facilitate fungal infection. Sci Adv 2020 Mar 25;6(13):eaaz1659
  4. Zhang Z, Gu J, Yin M, Wang D, Ma C, Du J, Lin Z, Hu S, Wang X, Li Y, Tan G*, Luo H*, Wei G*. Establishment and investigation of a multiple gene expression signature to predict long-term survival in pancreatic cancer. Biomed Res Int 2020 Sep 15;2020:1570862
  5. Zhang Y, Zou X, Qian W, Weng X, Zhang L, Zhang L, Wang S, Cao X, Ma L, Wei G*, Wu Y*, Hou Z*. Enhanced PAPSS2/VCAN sulfation axis is essential for Snail-mediated breast cancer cell migration and metastasis. Cell Death Differ 2019 Mar;26(3):565-579
  6. Li QL, Lei PJ, Zhao QY, Li L, Wei G*, Wu M*. Epigenomic analysis in a cell-based model reveals the roles of H3K9me3 in breast cancer transformation. Epigenomics 2017 Aug;9(8):1077-1092
  7. Gao Y, Zhang X, Zhang L, Cen J, Ni X, Liao X, Yang C, Li Y, Chen X, Zhang Z, Shu Y, Cheng X, Hay DC, Lai D, Pan G, Wei G*, Hui L*. Distinct gene expression and epigenetic signatures in hepatocyte-like cells produced by different strategies from the same donor. Stem Cell Reports 2017 Dec 12;9(6):1813-1824
  8. Han Z, Wei G*. Computational tools for Hi-C data analysis. Quant Biol 2017 Sep;5(3):215-225
  9. Ji S, Zhu L, Gao Y, Zhang X, Yan Y, Cen J, Li R, Zeng R, Liao L, Hou C, Gao Y, Gao S, Wei G*, Hui L*. Baf60B-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening. Cell Res 2017 May;27(5):642-656
  10. Lv X, Han Z, Chen H, Yang B, Yang X, Xia Y, Pan C, Fu L, Zhang S, Han H, Wu M, Zhou Z, Zhang L, Li L, Wei G*, Zhao Y*. A positive role for polycomb in transcriptional regulation via H4K20me1. Cell Res 2016 May;26(5):529-542
  11. Zhao QY, Lei PJ, Zhang X, Zheng JY, Wang HY, Zhao J, Li YM, Ye M, Li L, Wei G*, Wu M*. Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model. Clin Epigenetics 2016 Mar 31;8:34
  12. Gu J, Wang D, Zhang J, Zhu Y, Li Y, Chen H, Shi M, Wang X, Shen B, Deng X, Zhan Q, Wei G*, Peng C*. GFRalpha2 prompts cell growth and chemoresistance through down-regulating tumor suppressor gene PTEN via Mir-17-5p in pancreatic cancer. Cancer Lett 2016 Oct 1;380(2):434-441
  13. Chepelev I#, Wei G#, Wangsa D, Tang Q, Zhao K*. Characterization of genome-wide enhancer-promoter interactions reveals co-expression of interacting genes and modes of higher order chromatin organization. Cell Res 2012 Mar;22(3):490-503
  14. Wei G#, Abraham BJ#, Yagi R#, Jothi R#, Cui K, Sharma S, Narlikar L, Northrup DL, Tang Q, Paul WE, Zhu J*, Zhao K*. Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types. Immunity 2011 Aug 26;35(2):299-311