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QIAN Youcun

Ph.D.

Professor, Principal Investigator

Laboratory of Molecular Systems Biology

Email:ycqian@sibs.ac.cn

Tel: 86-21-54923331

Research Areas: Molecular mechanisms of inflammatory diseases including autoimmune diseases, infectious diseases and cancer.  

 

Brief Biography:  

Education  

1996 - 1999: Ph.D. in Molecular Pharmacology, Shanghai Institute of Materia Medica,  

Chinese Academy of Sciences. 

1987 - 1990: MS in cell biology, Nanjing Normal University. 

1983 - 1987: BS in biology, Nanjing Normal University 

Professional experience 

2017 - PresentProfessor, Principal Investigator, Shanghai Institute of Nutrition and Health, CAS  

2007 – 2016: Professor, Principal Investigator, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine 

2005 – 2007: Project Staff, Department of Immunology, Cleveland Clinic Foundation, Ohio.  

2003 – 2005: Research associate, Department of Immunology, Cleveland Clinic Foundation, Ohio.  

2000 – 2003: Post-doctoral fellow, Department of Immunology, Cleveland Clinic Foundation, Ohio. 

1990 1996: Pharmaceutical Engineer, Yangzhou Pharmaceutical Institute, Jiangsu, China. 

 

Selected Publications:*Corresponding Author 

1. Liu R, Lu Z, Gu J, Liu J, Huang E, Liu X, Wang L, Yang J, Deng Y, Qian J, Luo F, Wang Z, Zhang H, Jiang X, Zhang D, Qian J, Liu G, Zhu H, Qian Y, Liu Z, Chu Y. MicroRNAs 15A and 16-1 Activate Signaling Pathways That Mediate Chemotaxis of Immune Regulatory B cells to Colorectal Tumors. Gastroenterology. 2017 Oct 11. pii: S0016-5085(17)36240-6. doi: 10.1053/j.gastro.2017.09.045. 

2. Shao X, Chen S, Yang D, Cao M, Yao Y, Wu Z, Li N, Shen N, Li X, Song X*, Qian Y*. FGF2 cooperates with IL-17 to promote autoimmune inflammation. Sci Rep. 2017 Aug 1;7(1):7024. doi: 10.1038/s41598-017-07597-8. 

3. Yao Y, Chen S, Cao M, Fan X, Yang T, Huang H, Song X, Li Y, Ye L, Shen N, Shi Y, Li X, Wang F*, Qian Y*. Antigen-specific CD8t T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin. Nat. Commun. 2017 May 24;8:15402. doi: 10.1038/ncomms15402. 

4. Xia M, Liu J, Liu S, Chen K, Lin H, Jiang M, Xu X, Xue Y, Liu W, Gu Y, Zhang X, Li Z, Yi L, Qian Y, Zhou C, Li R, Zhang X, Li Z, Cao X. Ash1l and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T cell autoimmunity. Nat Commun. 2017 Jun 9;8:15818. doi: 10.1038/ncomms15818.

5. Wang C, Zhang CJ, Martin BN, Bulek K, Kang Z, Zhao J, Bian G, Carman JA, Gao J, Dongre A, Xue H, Miller SD, Qian Y, Hambardzumyan D, Hamilton T, Ransohoff RM, Li X. IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression. Nat Commun. 2017 May 31;8:15508. doi: 10.1038/ncomms15508.

6. Ma, C., Lin, W., Liu, Z., Tang, W., Gautam, R., Li, H., Qian, Y., Huang, H., Wang, X. NDR1 protein kinase promotes IL-17- and TNF-{alpha}-mediated inflammation by competitively binding TRAF3. EMBO Rep. 2017; 0:embr.201642140v1-e201642140.  

7. Song X, He X, Li X and Qian Y*. The roles and functional mechanisms of Interleukin-17 family cytokines in mucosal immunity. Cell Mol Immunol. 2016 Jul;13(4):418-31.  (Invited review). 

8. Wang J, Song X, Qian Y*. The research progress of IL-17 family cytokines. Biological Science2016, 28(2): 170-181 

9. Song X, Dai D, He X, Zhu S, Yao Y, Gao H, Wang J, Qu F, Qiu J, Wang H, Li X, Shen N*, and Qian Y*. Growth Factor FGF2 Cooperates with Interleukin-17 to Repair Intestinal Epithelial Damage. Immunity 43 (3): 488–501, 15 September 2015. 

10. Zhang L, Ke F, Liu Z, Bai J, Liu J, Yan S, Xu Z, Lou F, Wang H, Zhu H, Sun Y, Cai W1, Gao Y, Li Q, Yu XZ, Qian Y, Hua Z, Deng J, Li QJ, Wang H. MicroRNA-31 negatively regulates peripherally derived regulatory T-cell generation by repressing retinoic acid-inducible protein 3. Nat Commun. 2015 Jul 13;6:7639. doi: 10.1038/ncomms8639. 

11. Pan W, Zhu S, Dai D, Liu Z, Li D, Li B, Gagliani N, Zheng Y, Tang Y, Weirauch MT, Chen X, Zhu W, Wang Y, Chen B, Qian Y, Chen Y, Fang J, Herbst R, Richman L, Jallal B, Harley JB, Flavell RA, Yao Y, Shen N. MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis. Nat Commun. 2015 May 12;6:7096. 

12. Han X, Yang Q, Lin L, Xu C, Zheng C, Chen X, Han Y, Li M, Cao W, Cao K, Chen Q, Xu G, Zhang Y, Zhang J, Schneider RJ, Qian Y, Wang Y, Brewer G, Shi Y. Interleukin-17 Enhances Immunosuppression by Mesenchymal Stem Cells. Cell Death Differ. 2014 Nov;21(11):1758-68. 

13. Song X, Gao H, Qian Y*. Th17 Differentiation and Their Pro-inflammation Function. Adv Exp Med Biol. 2014;841:99-151. 

14. Song X, Gao H, Lin Y, Yao Y, Zhu S, Wang J, Liu Y, Yao X, Meng G, Shen N, Shi Y, Iwakura Y, Qian Y*. Alterations in the Microbiota Drive Interleukin-17C Production from Intestinal Epithelial Cells to Promote Tumorigenesis. Immunity. 2014 Jan 16;40(1):140-52.
(Featured by the journal; evaluated by Faculty of 1000) 

15. Song X, Qian Y*. IL-17 family cytokines mediated signaling in the pathogenesis of inflammatory diseases. Cell Signal. 2013 Jul 31;25(12):2335-2347. 

16. Song X, Qian Y*. Peli1 sets the CNS on fire. Nat Med. 2013 May;19(5):536-8.  

17. Shu Z*, Pan W, Qian Y*. MicroRNA in immunity and autoimmunity. J Mol Med (Berl). 2013 Sep;91(9):1039-50. 

18. Song X, Qian Y*. The activation and regulation of IL-17 receptor mediated signaling. Cytokine. 2013 May;62(2):175-82. 

19. Yao Y, Qian Y*. Expression regulation and function of NLRC5. Protein Cell. 2013 Mar;4(3):168-75. doi: 10.1007/s13238-012-2109-3. Epub 2013 Mar 13.  

20. Qu F, Gao H, Zhu S, Shi P, Zhang Y, Liu Y, Jallal B, Yao Y, Shi Y and Qian Y*. TRAF6 dependent Act1 phosphorylation by the IKK-related kinases suppresses IL-17-induced NF-κB activation. Mol. Cell. Biol.. (2012) 32(19):3925-37.  

21. Zhu S, Pan W, Song X, Liu Y, Shao X, Tang Y, Liang D, He D, Wang H, Liu W, Shi Y, Harley J, Shen N* and Qian Y*. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. Nat. Med. (2012)18(7)1077-1086.  
(News and Views in Nat. Med. 18,1009–1010,2012; Research highlighted in Nat. Rev. Immunol., doi:10.1038/nri3250, 2012; evaluated by F1000, 2012).  

22. Yao Y, Wang Y, Chen F, Huang Y, Zhu S, Leng Q, Wang H, Shi Y, Qian Y*. NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens. Cell Res. (2012) 22(5):836-47.  (Research highlighted by Cell Res. (2012) 22(7):1099-101; Research highlighted by A IBMN. Featured article in NPG immunology website.) 

23. Zhu S and Qian Y*. IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential. Clinical Science (2012) 122(11), 487-511.  

24. Shi P, Zhu S, Lin YY, Liu YF, Liu Y, Chen Z, Shi Y, Qian Y*. Persistent Stimulation with Interleukin-17 Desensitizes Cells through SCF-TrCP–Mediated Degradation of Act1. Sci. Signal. 4(197), ra73, 2011. 

25. Song X, Zhu S, Shi P, Liu Y, Shi Y, Levin SD, Qian Y* (2011) IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens. Nat Immunol. 12(12) 1151-1158.  (News and views in Nature Immunology12121131–11332011. Research highlighted in Nature Reviews Immunology, doi:10.1038/nri3118. Previewed in Immunity 35, 498-500, October 28, 2011. Featured article in NPG website. Evaluated twice as top 2% in Faculty of 1000 Biology and medicine).  

26. Shi P, Zhu S and Y Qian*. Research on IL-17 mediated signaling and function. Chinese Journal of Cell Biology 2011, 33(4): 345-357.  

27. Zhu S, Pan W, Shi P, Gao H, Zhao F, Song X, Liu Y, Zhao L, Li X, Shi Y, Qian Y*. (2010) Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling. J Exp Med. 207(12):2647-62.  (Research highlighted by Nat. Med. (2011) 17: 52by Nat. Immunol. (2011) 12: 19 and by SciBX (the Science Business eXchange); evaluated as top 2% in Faculty of 1000 Biology and Medicine.  

28. Qian Y*, Kang Z, Liu C, Li X*. 2010IL-17 signaling in host defense and inflammatory diseases. Cell Mol Immunol. 7(5):328-33.  

29. Qian Y, Shi Y. 2009Natural killer cells go inside: entosis versus cannibalism. Cell Res. 19(12):1320-1. 

30. Liu C, Qian W, Qian Y, Giltiay NV, Lu Y, Swaidani S, Misra S, Deng L, Chen ZJ, Li X. 2009Act1, a U-box E3 ubiquitin ligase for IL-17 signaling. Sci Signal. 2(92):ra63.  

31. Qian Y, Giltiay N, Xiao J, Wang Y, Tian J, Han S, Scott M, Carter R, Jorgensen T and Li X. (2008) Deficiency of Act1, a critical modulator of B cell function, leads to development of Sjogren’s syndrome. Eur J Immunol. 38(8):2219-28. (evaluated in Faculty of 1000 Biology). 

32. Xiao H, Qian W, Staschke K, Qian Y, Cui G, Deng L, Ehsani M, Wang X, Qian YW, Chen ZJ, Gilmour R, Jiang Z, Li X 2008Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kappaB activation. J Biol Chem. 83(21): 14654-64. 

33. Qian Y, Liu C, Hartupee J, Altuntas CZ, Gulen MF, Jane-Wit D, Xiao J, Lu Y, Giltiay N, Liu J, Kordula T, Zhang QW, Vallance B, Swaidani S, Aronica M, Tuohy VK, Hamilton T, Li X. (2007) The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease. Nat Immunol. 8(3):247-56.  (Previewed in Nat Immunol., 2007, 8(3):232-234 and Highlighted in Cell Leading Edge20071281019). 

34. Yao J, Kim T, Qin J, Jiang Z, Qian Y, Xiao H, Lu Y, Wen Q, Gulen MF, Sizemore N, Didonato J, Sato S, Akira S, Su B, Li X. (2007) IL-1-induced TAK1- versus MEKK3-dependent NFkB activation pathways bifurcate at IRAK modification. J Biol Chem. 282(9):6075-89. 

35. Qin J, Qian Y, Yao J, Cui G, Li X. (2005) SIGIRR inhibits IL-1R-and TLR4-mediated signaling through different mechanisms. J Biol Chem. 280(26):25233-41. 

36. Qian Y, Qin J, Cui G, Naramura M, Snow EC, Ware CF, Fairchild RL, Omori SA, Rickert RC, Scott M, Kotzin BL, Li X. (2004) Act1, a negative regulator in CD40- and BAFF- mediated B cell survival. Immunity. 21(4): 575-587. 

37. Qin J, Jiang Z, Qian Y, Casanova JL, Li X. (2004) IRAK4 kinase activity is redundant for interleukin-1 (IL-1) receptor-associated kinase phosphorylation and IL-1 responsiveness. J Biol Chem. 279(25):26748-53. 

38. Zhao Z, Qian Y, Wald D, Xia YF, Geng JG, Li X. (2003) IFN regulatory factor-1 is required for the up-regulation of the CD40-NF-kappa B activator 1 axis during airway inflammation. J Immunol. 170(11):5674-80. 

39. Wald D, Qin J, Zhao Z, Qian Y, Naramura M, Tian L, Towne J, Sims JE, Stark GR, Li X. (2003) SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol. 4(9):920-7. 

40. Qian Y., Zhao Z., Jiang Z., and Li, X. (2002) Role of NF-kB activator Act1 in CD40-mediated signaling in epithelial cells. Proc. Natl. Acad. Sci. USA. 99: 9386-9391. 

41. Jiang Z., Ninomiya-Tsuji J., Qian Y., Matumoto K., and Li X. (2002) IRAK-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol. Mol. Cell. Biol. 20(20): 7158-7167. 

42. Qian Y, Commane M, Ninomiya-Tsuji J, Matsumoto K, Li X. (2001) IRAK-mediated translocation of TRAF6 and TAB2 in the IL-1-induced activation of NFkB. J. Biol. Chem. 276(45): 41661-41667. 

43. Yang YG, Tong Q, Zheng WD, Qian YC, Yang SL and Gong Y. The effect of over-expression of chaperones on the secretion and solubility of proteins. Chin. J. Biochem. Mol. Biol., 2000, 16(3): 382-387. 

44. Qian YC, Shen Y, Fan CY, Hu TS, Yang SL and Gong Y. Expression and characterization of two kinds of recombinant snake neurotoxins. Chin. J. Biotechnol., 2000, 16(3):312-5. 

45. Yang YG, Tong Q, Hu TS, Qian YC, Yang SL and Gong Y. The application of a novel lytic system to the recovery of recombinant proteins in E. coli. Acta Biochimia et Biophysica Sinica, 2000, 32(3): 211-216. 

46. Hu TS, Chen HU, Yang YG, Qian YC, Qu XM and Yang SL. Construction and Expression of ScFv Against Antibacterial Peptide Magainin II. Journal of Cellular and Molecular Immunology 2000, 16(4): 317-320. 

47. Qian YC, Hu TS, Fan CY, Yang YG, Yang SL and Gong Y. The immunological analyses of ten neurotoxin-like proteins from snakes. Chin. J. Biochem. Mol. Biol. 2000, 16(3): 340-345. 

48. Hu TS, Qian YC, Yang YG, Hu YL, Qu XM and Yang SL. Preparation and cDNA sequence analysis of two novel monoclonal antibodies against Magainin II. Hybridoma, 2000, 19(1): 95-99. 

49. Qian YC, Fan CY, Hu TS, Yang YG, Yang SL and Gong Y. cDNA cloning and functional expression of a-bungarotoxin (V31) from Chinese continental banded krait. Animal Research, 2000, 21(1): 41-47. 

50. Yang YG, Xu JN, Hu TS, Qian YC, Yang SL and Gong Y. Increase in hydrophobility of signal peptide enhances the secretion of penicillin G acylase. Acta Biochimia et Biophysica Sinica, 1999, 32(2): 48-52. 

51. Fan CY, Qian YC, Shen Y, Yang SL and Gong Y. Molecular cloning and expression of the cDNA for Disintegrin from Agkistrodon acutus. Acta Biochimica et Biophysica Sinica, 1999, 31(5): 531-536. 

52. Qian YC, Fan CY, Liu XL, Hu TS, Yang SL and Gong Y. Molecular cloning and expression of a new A chain of beta-Bungarotoxin. Acta Biochimica et Biophysica Sinica, 1999, 31(6): 689-694. 

53. Fan CY, Qian YC, Yang SL and Gong Y. Molecular cloning and sequence analysis of the cDNA for metalloproteinase from the venom of Agkistrodon acutus. Chin. J. Biochem. Mol. Biol., 1999, 15(5): 687-691. 

54. Fan CY, Qian YC, Yang SL and Gong Y. Cloning, sequence analysis and expression in E. coli of the cDNA of thrombin-like enzyme (pallabin) from the venom of Agkistrodon acutus. Biochem. Mol. Biol. Int., 1999, 47(2): 217-225. 

55. Qian YC, Fan CY, Gong Y and Yang SL. CDNA sequence analysis of a novel member of the three loop protein family from Chinese continental banded krait, Biosci. Biotechnol. Biochem., 1999, 63(5): 940-942.  

56. Fan CY, Qian YC, Yang SL and Gong Y. cDNA cloning and sequence analysis of the cDNA for lys-49 phospholipase A2 from Agkistrodon acutus. Genetic Analysis (Biomolecular Engineering). 1999, 15: 15-18. 

57. Qian YC, Fan CY, Gong Y and Yang SL. cDNA cloning and sequence analysis of six neurotoxin-like proteins form Chinese continental banded krait. Biochem. Mol. Biol. Int., 1998, 46(4): 821-828.  

58. Qian YC, Fan CY, Gong Y and Yang SL. cDNA sequence analysis and expression of four long neurotoxin homologues from Naja naja atra. Biochim. Biophys. Acta, 1998, 1443: 233-238.