Research Areas
Molecular mechanisms of inflammatory diseases including autoimmune diseases, infectious diseases and cancer.

Brief Biography
Education
1996 - 1999: Ph.D. in Molecular Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
1987 - 1990: MS in cell biology, Nanjing Normal University
1983 - 1987: BS in biology, Nanjing Normal University
Professional experience
2017 - Present： Professor, Principal Investigator, Shanghai Institute of Nutrition and Health, CAS
2007 – 2016: Professor, Principal Investigator, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine
2005 – 2007: Project Staff, Department of Immunology, Cleveland Clinic Foundation, Ohio
2003 – 2005: Research associate, Department of Immunology, Cleveland Clinic Foundation, Ohio
2000 – 2003: Post-doctoral fellow, Department of Immunology, Cleveland Clinic Foundation, Ohio
1990 – 1996: Pharmaceutical Engineer, Yangzhou Pharmaceutical Institute, Jiangsu, China

Selected Publications (*Corresponding Author)

1. Zeng F#, Chen H#, Chen L, Mao J, Cai S, Xiao Y, Li J, Shi J, Li B, Xu Y, Tan Z, Gong F, Li B, Qian Y, Dong L, Zheng F*. An Autocrine Circuit of IL-33 in Keratinocytes Is Involved in the Progression of Psoriasis. J Invest Dermatol 2021 Mar;141(3):596-606.
2. Yang D, Chen X, Wang J, Lou Q, Lou Y, Li L, Wang H, Chen J, Wu M, Song X, Qian Y*. Dysregulated Lung Commensal Bacteria Drive Interleukin-17B Production to Promote Pulmonary Fibrosis through Their Outer Membrane Vesicles. Immunity 2019 Mar 19;50(3):692-706.
3. Liu R, Lu Z, Gu J, Liu J, Huang E, Liu X, Wang L, Yang J, Deng Y, Qian J, Luo F, Wang Z, Zhang H, Jiang X, Zhang D, Qian J, Liu G, Zhu H, Qian Y, Liu Z, Chu Y. MicroRNAs 15A and 16-1 Activate Signaling Pathways That Mediate Chemotaxis of Immune Regulatory B cells to Colorectal Tumors. Gastroenterology 2018 Feb;154(3):637-651.
4. Shao X, Chen S, Yang D, Cao M, Yao Y, Wu Z, Li N, Shen N, Li X, Song X*, Qian Y*. FGF2 cooperates with IL-17 to promote autoimmune inflammation. Sci Rep 2017 Aug 1;7(1):7024.
5. Xia M, Liu J, Liu S, Chen K, Lin H, Jiang M, Xu X, Xue Y, Liu W, Gu Y, Zhang X, Li Z, Yi L, Qian Y, Zhou C, Li R, Zhang X, Li Z, Cao X. Ash1l and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T cell autoimmunity. Nat Commun 2017 Jun 9;8:15818.
6. Yao Y, Chen S, Cao M, Fan X, Yang T, Huang H, Song X, Li Y, Ye L, Shen N, Shi Y, Li X, Wang F*, Qian Y*. Antigen-specific CD8t T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin. Nat Commun 2017 May 24;8:15402.
7. Wang C, Zhang CJ, Martin BN, Bulek K, Kang Z, Zhao J, Bian G, Carman JA, Gao J, Dongre A, Xue H, Miller SD, Qian Y, Hambardzumyan D, Hamilton T, Ransohoff RM, Li X. IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression. Nat Commun 2017 May 31;8:15508.
8. Ma C, Lin W, Liu Z, Tang W, Gautam R, Li H, Qian Y, Huang H, Wang X. NDR1 protein kinase promotes IL-17- and TNF-{alpha}-mediated inflammation by competitively binding TRAF3. EMBO Rep 2017 Apr;18(4):586-602.
9. Song X, He X, Li X, Qian Y*. The roles and functional mechanisms of Interleukin-17 family cytokines in mucosal immunity. Cell Mol Immunol 2016 Jul;13(4):418-431. (Invited review)
10. Wang J, Song X, Qian Y*. The research progress of IL-17 family cytokines. Biological Science 2016;28(2):170-181。
11. Song X, Dai D, He X, Zhu S, Yao Y, Gao H, Wang J, Qu F, Qiu J, Wang H, Li X, Shen N*, Qian Y*. Growth Factor FGF2 Cooperates with Interleukin-17 to Repair Intestinal Epithelial Damage. Immunity 2015 Sep 15;43(3):488–501.
12. Zhang L, Ke F, Liu Z, Bai J, Liu J, Yan S, Xu Z, Lou F, Wang H, Zhu H, Sun Y, Cai W1, Gao Y, Li Q, Yu XZ, Qian Y, Hua Z, Deng J, Li QJ, Wang H. MicroRNA-31 negatively regulates peripherally derived regulatory T-cell generation by repressing retinoic acid-inducible protein 3. Nat Commun 2015 Jul 13;6:7639.
13. Pan W, Zhu S, Dai D, Liu Z, Li D, Li B, Gagliani N, Zheng Y, Tang Y, Weirauch MT, Chen X, Zhu W, Wang Y, Chen B, Qian Y, Chen Y, Fang J, Herbst R, Richman L, Jallal B, Harley JB, Flavell RA, Yao Y, Shen N. MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis. Nat Commun 2015 May 12;6:7096.
14. Han X, Yang Q, Lin L, Xu C, Zheng C, Chen X, Han Y, Li M, Cao W, Cao K, Chen Q, Xu G, Zhang Y, Zhang J, Schneider RJ, Qian Y, Wang Y, Brewer G, Shi Y. Interleukin-17 Enhances Immunosuppression by Mesenchymal Stem Cells. Cell Death Differ 2014 Nov;21(11):1758-1768.
15. Song X, Gao H, Qian Y*. Th17 Differentiation and Their Pro-inflammation Function. Adv Exp Med Biol 2014:841:99-151.
16. Song X, Gao H, Lin Y, Yao Y, Zhu S, Wang J, Liu Y, Yao X, Meng G, Shen N, Shi Y, Iwakura Y, Qian Y*. Alterations in the Microbiota Drive Interleukin-17C Production from Intestinal Epithelial Cells to Promote Tumorigenesis. Immunity 2014 Jan 16;40(1):140-152.
    (Featured by the journal; evaluated by Faculty of 1000)
17. Shu Z*, Pan W, Qian Y*. MicroRNA in immunity and autoimmunity. J Mol Med (Berl) 2013 Sep;91(9):1039-1050.
18. Song X, Qian Y*. IL-17 family cytokines mediated signaling in the pathogenesis of inflammatory diseases. Cell Signal 2013 Jul 31;25(12):2335-2347.
19. Song X, Qian Y*. The activation and regulation of IL-17 receptor mediated signaling. Cytokine 2013 May;62(2):175-182.
20. Song X, Qian Y*. Peli1 sets the CNS on fire. Nat Med 2013 May;19(5):536-538.
21. Yao Y, Qian Y*. Expression regulation and function of NLRC5. Protein Cell 2013 Mar;4(3):168-175.
22. Qu F, Gao H, Zhu S, Shi P, Zhang Y, Liu Y, Jallal B, Yao Y, Shi Y, Qian Y*. TRAF6-dependent Act1 phosphorylation by the IκB kinase-related kinases suppresses interleukin-17-induced NF-κB activation. Mol Cell Biol 2012 Oct;32(19):3925-3937.
23. Zhu S, Pan W, Song X, Liu Y, Shao X, Tang Y, Liang D, He D, Wang H, Liu W, Shi Y, Harley J, Shen N*, Qian Y*. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. Nat Med 2012 Jul;18(7):1077-1086.
    (News and Views in Nat Med 2012;18:1009–1010; Research highlighted in Nat Rev Immunol 2012;doi:10.1038/nri3250; evaluated by F1000, 2012).
24. Zhu S, Qian Y*. IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential. Clinical Science 2012 Jun;122(11):487-511.
25. Yao Y, Wang Y, Chen F, Huang Y, Zhu S, Leng Q, Wang H, Shi Y, Qian Y*. NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens. Cell Res 2012 May;22(5):836-847.
    (Research highlighted by Cell Res 2012;22(7):1099-1101; Research highlighted by A IBMN. Featured article in NPG immunology website.)
26. Shi P, Zhu S, Lin YY, Liu YF, Liu Y, Chen Z, Shi Y, Qian Y*. Persistent stimulation with interleukin-17 desensitizes cells through SCFβ-TrCP-mediated degradation of Act1. Sci Signal 2011 Nov 1;4(197):ra73.
27. Song X, Zhu S, Shi P, Liu Y, Shi Y, Levin SD, Qian Y*. IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens. Nat Immunol 2011 Oct 12;12(12):1151-1158.
    (News and views in Nature Immunol 2011 Oct;12(12):1131–1133. Research highlighted in Nature Reviews Immunology doi:10.1038/nri3118. Previewed in Immunity 2011 Oct 28;35:498-500. Featured article in NPG website. Evaluated twice as top 2% in Faculty of 1000 Biology and medicine)
28. Shi P, Zhu S, Qian Y*. Research on IL-17 mediated signaling and function. Chinese Journal of Cell Biology 2011 Apr;33(4):345-357.
29. Zhu S, Pan W, Shi P, Gao H, Zhao F, Song X, Liu Y, Zhao L, Li X, Shi Y, Qian Y*. Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling. J Exp Med 2010 Nov 22;207(12):2647-2662.
    (Research highlighted by Nat Med 2011;17:52, by Nat Immunol 2011;12:19 and by SciBX (the Science Business eXchange); evaluated as top 2% in Faculty of 1000 Biology and Medicine)
30. Qian Y*, Kang Z, Liu C, Li X*. IL-17 signaling in host defense and inflammatory diseases. Cell Mol Immunol 2010 Sep;7(5):328-333.
31. Qian Y, Shi Y. Natural killer cells go inside: entosis versus cannibalism. Cell Res 2009 Dec;19(12):1320-1321.
32. Liu C, Qian W, Qian Y, Giltiay NV, Lu Y, Swaidani S, Misra S, Deng L, Chen ZJ, Li X. Act1, a U-box E3 ubiquitin ligase for IL-17 signaling. Sci Signal 2009 Oct 13;2(92):ra63.
33. Qian Y, Giltiay N, Xiao J, Wang Y, Tian J, Han S, Scott M, Carter R, Jorgensen T and Li X. Deficiency of Act1, a critical modulator of B cell function, leads to development of Sjogren’s syndrome. Eur J Immunol 2008 Aug;38(8):2219-2228.
    (evaluated in Faculty of 1000 Biology)
34. Xiao H, Qian W, Staschke K, Qian Y, Cui G, Deng L, Ehsani M, Wang X, Qian YW, Chen ZJ, Gilmour R, Jiang Z, Li X. Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kappaB activation. J Biol Chem 2008 May 23;283(21):14654-14664.
35. Qian Y, Liu C, Hartupee J, Altuntas CZ, Gulen MF, Jane-Wit D, Xiao J, Lu Y, Giltiay N, Liu J, Kordula T, Zhang QW, Vallance B, Swaidani S, Aronica M, Tuohy VK, Hamilton T, Li X. The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease. Nat Immunol 2007 Mar;8(3):247-256.
    (Previewed in Nat Immunol 2007;8(3):232-234 and Highlighted in Cell Leading Edge：2007;128:1019)
36. Yao J, Kim T, Qin J, Jiang Z, Qian Y, Xiao H, Lu Y, Wen Q, Gulen MF, Sizemore N, Didonato J, Sato S, Akira S, Su B, Li X. IL-1-induced TAK1- versus MEKK3-dependent NFkB activation pathways bifurcate at IRAK modification. J Biol Chem 2007 Mar 2;282(9):6075-6089.
37. Qin J, Qian Y, Yao J, Cui G, Li X. SIGIRR inhibits IL-1R-and TLR4-mediated signaling through different mechanisms. J Biol Chem 2005 Jul 1;280(26):25233-25241.
38. Qian Y, Qin J, Cui G, Naramura M, Snow EC, Ware CF, Fairchild RL, Omori SA, Rickert RC, Scott M, Kotzin BL, Li X. (2004) Act1, a negative regulator in CD40- and BAFF- mediated B cell survival. Immunity 2004 Oct;21(4):575-587.
39. Qin J, Jiang Z, Qian Y, Casanova JL, Li X. IRAK4 kinase activity is redundant for interleukin-1 (IL-1) receptor-associated kinase phosphorylation and IL-1 responsiveness. J Biol Chem 2004 Jun 18;279(25):26748-26753.
40. Zhao Z, Qian Y, Wald D, Xia YF, Geng JG, Li X. IFN regulatory factor-1 is required for the up-regulation of the CD40-NF-kappa B activator 1 axis during airway inflammation. J Immunol 2003 Jun 1;170(11):5674-5680.
41. Wald D, Qin J, Zhao Z, Qian Y, Naramura M, Tian L, Towne J, Sims JE, Stark GR, Li X. SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol 2003 Sep;4(9):920-927.
42. Qian Y, Zhao Z, Jiang Z, Li X. Role of NF-kB activator Act1 in CD40-mediated signaling in epithelial cells. Proc Natl Acad Sci USA 2002 Jul 9;99(14):9386-9391.
43. Jiang Z, Ninomiya-Tsuji J, Qian Y, Matumoto K, Li X. IRAK-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol. Mol Cell Biol 2002 Oct;22(20):7158-7167.
44. Qian Y, Commane M, Ninomiya-Tsuji J, Matsumoto K, Li X. IRAK-mediated translocation of TRAF6 and TAB2 in the IL-1-induced activation of NFkB. J Biol Chem 2001 Nov 9;276(45):41661-41667.
45. Yang YG, Tong Q, Zheng WD, Qian YC, Yang SL, Gong Y. The effect of over-expression of chaperones on the secretion and solubility of proteins. Chin J Biochem Mol Biol 2000 Jun;16(3):382-387.
46. Qian YC, Shen Y, Fan CY, Hu TS, Yang SL, Gong Y. Expression and characterization of two kinds of recombinant snake neurotoxins. Chin J Biotechnol 2000 May;16(3):312-315.
47. Yang YG, Tong Q, Hu TS, Qian YC, Yang SL, Gong Y. The application of a novel lytic system to the recovery of recombinant proteins in E. coli. Acta Biochimia et Biophysica Sinica 2000 Jun;32(3):211-216.
48. Hu TS, Chen HU, Yang YG, Qian YC, Qu XM, Yang SL. Construction and Expression of ScFv Against Antibacterial Peptide Magainin II. Journal of Cellular and Molecular Immunology 2000 Jan;16(4):317-320.
49. Qian YC, Hu TS, Fan CY, Yang YG, Yang SL, Gong Y. The immunological analyses of ten neurotoxin-like proteins from snakes. Chin J Biochem Mol Biol 2000 Jun;16(3):340-345.
50. Hu TS, Qian YC, Yang YG, Hu YL, Qu XM, Yang SL. Preparation and cDNA sequence analysis of two novel monoclonal antibodies against Magainin II. Hybridoma 2000 Feb;19(1):95-99.
51. Qian YC, Fan CY, Hu TS, Yang YG, Yang SL, Gong Y. cDNA cloning and functional expression of a-bungarotoxin (V31) from Chinese continental banded krait. Animal Research 2000;21(1):41-47.
52. Qian YC, Fan CY, Liu XL, Hu TS, Yang SL, Gong Y. Molecular cloning and expression of a new A chain of beta-Bungarotoxin. Acta Biochimica et Biophysica Sinica 1999 Dec;31(6):689-694.
53. Fan CY, Qian YC, Yang SL, Gong Y. Molecular cloning and sequence analysis of the cDNA for metalloproteinase from the venom of Agkistrodon acutus. Chin J Biochem Mol Biol 1999 Oct;15(5):687-691.
54. Fan CY, Qian YC, Shen Y, Yang SL, Gong Y. Molecular cloning and expression of the cDNA for Disintegrin from Agkistrodon acutus. Acta Biochimica et Biophysica Sinica 1999 Oct;31(5):531-536.
55. Qian YC, Fan CY, Gong Y, Yang SL. cDNA sequence analysis of a novel member of the three loop protein family from the Chinese continental banded krait. Biosci Biotechnol Biochem 1999 May;63(5):940-942.
56. Fan CY, Qian YC, Yang SL, Gong Y. cDNA cloning and sequence analysis of the cDNA for lys-49 phospholipase A2 from Agkistrodon acutus. Genet Anal 1999 Mar;15(1):15-18.
57. Fan CY, Qian YC, Yang SL, Gong Y. Cloning, sequence analysis and expression in E. coli of the cDNA of thrombin-like enzyme (pallabin) from the venom of Agkistrodon acutus. Biochem Mol Biol Int 1999 Feb;47(2):217-225.
58. Qian YC, Fan CY, Gong Y, Yang SL. cDNA cloning and sequence analysis of six neurotoxin-like proteins form Chinese continental banded krait. Biochem Mol Biol Int 1998 Nov;46(4):821-828.
59. Qian YC, Fan CY, Gong Y, Yang SL. cDNA sequence analysis and expression of four long neurotoxin homologues from Naja naja atra. Biochim Biophys Acta 1998 Nov 26;1443(1-2):233-238.