Research Areas
Our laboratory interests on the regulatory cell signaling network in vascular and hematopoietic system, and recently focus on 1) hematopoietic stem cell emergence from and retention into proliferative vascular niche and 2) adaptation of naive or transplanted HSC into its niche to re/establish blood circulation.

Brief Biography
Education
1999 - 2005: Ph.D., Molecular Biology and Biochemistry, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Science, Shanghai, China
1995 - 1999: B.S., Biochemistry, East China University of Science and Technology, Shanghai, China
Professional Experience
2017 - Present: Professor, Principal Investigator, Shanghai Institute of Nutrition and Health, CAS
2012 - 2016: Professor, Principal Investigator, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, China
2009 - 2012: Research Fellow, Program in Genomics of Differentiation, NICHD, NIH, Bethesda, Maryland, USA
2005 - 2009: Associate Research Scientist, Department of Pharmacology, School of Medicine, Yale University, New Haven, Connecticut, USA

Selected Publications (*Corresponding Author)

1. Wu S#, Chen K#, Xu T#, Ma K, Gao L, Fu C, Zhang W, Jing C, Ren C, Deng M, Chen Y, Zhou Y, Pan W*, Jia X*. Tpr Deficiency Disrupts Erythroid Maturation With Impaired Chromatin Condensation in Zebrafish Embryogenesis. Front Cell Dev Biol 2021 Oct 13;9:709923.
2. Zhao W, Cao L, Ying H, Zhang W, Li D, Zhu X, Xue W, Wu S, Cao M, Fu C, Qi H, Hao Y, Tang YC, Qin J, Zhong TP, Lin X, Yu L, Li X, Li L, Wu D, Pan W*. Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition. Cell Res 2019 Nov;29(11):895-910.
3. Li D^#, Xue W^#, Li M^#, Dong M, Wang J, Wang X, Li X, Chen K, Zhang W, Wu S, Zhang Y, Gao L, Chen Y, Chen J, Zhou BO, Zhou Y, Yao X, Li L, Wu D, Pan W*. VCAM-1+ macrophages guide the homing of HSPCs to a vascular niche. Nature 2018 Dec;564(7734):119-124.
4. He X^#, Zhang W^#, Yan C^#, Nie F, Li C, Liu X, Fei C, Li S, Song X, Jia Y, Zeng R, Wu D, Pan W*, Hao X*, Li L*. Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/β-catenin transcriptional activity. Cell Discov 2017 Jan 31;3:17003.
5. Gao L, Li D, Ma K, Zhang W, Xu T, Fu C, Jing C, Jia X, Wu S, Sun X, Dong M, Deng M, Chen Y, Zhu W, Peng J, Wan F, Zhou Y, Zon LI, Pan W*. TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis. PLoS Genet 2015 Jul 1;11(7):e1005346.
6. Jia XE^#, Ma K^#, Xu T^#, Gao L, Wu S, Fu C, Zhang W, Wang Z, Liu K, Dong M, Jing C, Ren C, Dong Z, Chen Y, Jin Y, Huang Q, Chang X, Deng M, Li L, Luo L, Zhu J, Dang Y, Chang HC, Zon LI, Zhou Y*, Chen S*, Pan W*. Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction. Cell Res 2015 Aug;25(8):946-962.
7. Kim I^#, Pan W^#*, Jones SA, Zhang Y, Zhuang X, Wu D*. Clathrin and AP2 are required for PtdIns(4,5)P2-mediated formation of LRP6 signalosomes. J Cell Biol 2013 Feb 18;200(4):419-428.
8. Pan W^#, Pham VN, Stratman AN, Castranova D, Kamei M, Kidd KR, Lo BD, Shaw KM, Torres-Vazquez J, Mikelis CM, Gutkind JS, Davis GE, Weinstein BM. CDP-diacylglycerolsynthetase-controlled phosphoinositide availability limitsVEGFA signaling and vascular morphogenesis. Blood 2012 Jul 12;120(2):489-498.