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LU Wei

Ph.D.

Professor, Principal Investigator

Laboratory of Immunogenetics

Email:lvwei@sibs.ac.cn

Tel: 86-21-54923370

Research Areas:

“Immuno-metabolism” is an emerging field, in which the molecular and functional linkages among metabolism, immunity, and human immunological disease are just beginning to be explored. Consequently, there are many untapped opportunities to apply our growing understanding of immuno-metabolism to disease diagnosis and treatment. In my lab, we plan to study both genetically-altered mouse models and human patient samples to unravel how metabolic dysregulation contributes to human immunological diseases such as lymphoma, primary immunodeficiency (PID), and inflammatory disease. Ultimately, I hope that our work will identify new targets for precision medicine directed against these and other genetic metabolic disorders.


Brief Biography:

2017-Present: Professor, Principal Investigator, Shanghai Institute of Nutrition and Health, CAS

2016-2017: Professor, Principal Investigator, Shanghai Institutes for Biological Sciences/Joint Center for Translational Medicine (SIBS - Shanghai Changzheng Hospital), Institute for Translational Medicine (CAS-SMMU), Shanghai, China

2008-2016: Research Fellow, National Institutes of Health, NIAID, Lab of Immunology

2003-2008: Ph.D., Shanghai Institutes for Biological Sciences, CAS

1999-2003: Bachelor, China Pharmaceutical University Bio-technology


Selected Publications: (*Corresponding Author)

  1. Jia P, Li X, Wang X, Yao L, Xu Y, Hu Y, Xu W, He Z, Zhao Q, Deng Y, Zang Y, Zhang M, Zhang Y*, Qin J*, Lu W*. ZMYND8 mediated liquid condensates spatiotemporally decommission the latent super-enhancers during macrophage polarization. Nat Commun 2021 Nov 11;12(1):6535.
  2. Wei Z#, Zhang Y#, Chen J#, Hu Y#, Jia P, Wang X, Zhao Q, Deng Y, Li N, Zang Y, Qin J, Wang X*, Lu W*. Pathogenic CARD11 mutations affect B cell development and differentiation through a noncanonical pathway. Sci Immunol 2019 Nov 29;4(41):eaaw5618.
  3. Lu W#, Sun J#, Yoon J#, Zhang Y, Zheng L, Murphy E, Mattson MP, Lenardo MJ*. Mitochondrial protein PGAM5 regulates mitophagic protection against cell necroptosis. PLoS One 2016 Jan 25;11(1):e0147792.
  4. Lo B#, Zhang K#, Lu W, Zheng L, Zhang Q, Kanellopoulou C, Zhang Y, Liu Z, Fritz JM, Marsh R, Husami A, Kissell D, Nortman S, Chaturvedi V, Haines H, Young LR, Mo J, Filipovich AH, Bleesing JJ, Mustillo P, Stephens M, Rueda CM, Chougnet CA, Hoebe K, McElwee J, Hughes JD, Karakoc-Aydiner E*, Matthews HF, Price S, Su HC, Rao VK, Lenardo MJ*, Jordan MB*. AUTOIMMUNE DISEASE. Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy. Science 2015;349(6246):436-440.
  5. Lu W#, Zhang Y#, McDonald DO, Jing H, Carroll B, Robertson N, Zhang Q, Griffin H, Sanderson S, Lakey JH, Morgan NV, Reynard LN, Zheng L, Murdock HM, Turvey SE, Hackett SJ, Prestidge T, Hall J, Cant AJ, Matthews HM, Santibanez Koref MF, Simon AK, Korolchuk VI, Lenardo MJ, Hambleton S*, Su HC*. Dual Proteolytic Pathways Govern Glycolysis and Immune Competence. Cell 2014;159(7):1578–1590.
  6. Lu W#, Karuppagounder SS#, Springer DA, Allen MD, Zheng LX, Chao B, Zhang Y, Dawson VL, Dawson TM, Lenardo MJ*. Genetic deficiency of the mitochondrial protein PGAM5 causes a Parkinson’s-like movement disorder. Nat Commun 2014;5:4930.