Research Areas:

1. Regulation on differentiation of human stem cells to cardiovascular cell lineages.

2. Metabolism and molecular mechanism of atherosclerosis and vascular remodeling.

3. Mechanism of non-coding RNAs on post-transcriptional gene regulation in cardiovascular systems and their physiological, pathological significance.

Brief Biography:

I. Education

1994-1997 Ph.D. Second Military Medical University, Shanghai, China

1984-1990 M.D. Second Military Medical University, Shanghai, China

II. Major Academic Appointments

2007-Present Professor, Principal Investigator, Shanghai Institute of Nutrition and Health, CAS

2005-2006 Professor, Principal Investigator, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine

2000-2004 Guest Scientist, The Scripps Research Institute, San Diego, USA

1997-1999 Postdoctoral fellow, Shanghai Institute of Cell Biology, Chinese Academy of Sciences, Shanghai, China

1990-1997 Physician, Department of Cardiology, Changhai Hospital, Shanghai, China

Honors:

2012-present Fellow of American Heart Association (FAHA)

Selected Publications: (*Corresponding Author)

1. Guo FH^#, Guan YN^#, Guo JJ, Zhang LJ, Qiu JJ, Ji Y, Chen AF, Jing Q*. Single-Cell Transcriptome Analysis Reveals Embryonic Endothelial Heterogeneity at Spatiotemporal Level and Multifunctions of MicroRNA-126 in Mice. Arterioscler Thromb Vasc Biol 2022 Mar;42(3):326-342
2. Gao LB, Wang YH, Liu ZH, Sun Y, Cai P, Jing Q*. Identification of a small molecule SR9009 that activates NRF2 to counteract cellular senescence. Aging Cell 2021 Oct;20(10):e13483
3. Guan YN, Li Y, Roosan M, Jing Q*. Single-cell transcriptomics of murine mural cells reveals cellular heterogeneity. Sci China Life Sci 2021 Jul;64(7):1077-1086
4. Li FF, Liang YL, Han XS, Guan YN, Chen J, Wu P, Zhao XX, Jing Q*. ADP receptor P2y12 prevents excessive primitive hematopoiesis in zebrafish by inhibiting Gata1. Acta Pharmacol Sin 2021 Mar;42(3):414-421
5. Hu YX, Zhu RF, Qin YW, Zhao XX, Jing Q*. Zfp36l1b protects angiogenesis through Notch1b/Dll4 and Vegfa regulation in zebrafish. Atherosclerosis 2020 Sep;309:56-64.
6. Wang C, Yang ZZ, Guo FH, Shi S, Han XS, Zeng A, Lin H, Jing Q*. Heat shock protein DNAJA1 stabilizes PIWI proteins to support regeneration and homeostasis of planarian Schmidtea mediterranea. J Biol Chem 2019 Jun 21;294(25):9873-9887
7. Han XS, Wang C, Guo FH, Huang S, Qin YW, Zhao XX, Jing Q*. Neoblast-enriched zinc finger protein FIR1 triggers local proliferation during planarian regeneration. Protein Cell 2019 Jan;10(1):43-59
8. Song XW^#, Zou LL^#, Cui L, Li SH, Qin YW, Zhao XX, Jing Q*. Plasma miR-451 with echocardiography serves as a diagnostic reference for pulmonary hypertension. Acta Pharmacol Sin 2018 Jul;39(7):1208-1216
9. Wang C, Jing Q*. Non-coding RNAs as biomarkers for acute myocardial infarction. Acta Pharmacol Sin 2018 Jul;39(7):1110-1119
10. Qi MY^*#, Song JW^#, Zhang Z, Huang S, Jing Q*. P38 activation induces the dissociation of tristetraprolin from Argonaute 2 to increase ARE-mRNA stabilization. Mol Biol Cell 2018 Apr 15;29(8):988-1002
11. Li Y*, Zeng A, Han XS, Li G, Li YQ, Shen B**, Jing Q*. Small RNAome sequencing delineates the small RNA landscape of pluripotent adult stem cells in the planarian Schmidtea mediterranea. Genom Data 2017 Oct 25;14:114-125
12. Dong J^#, Bao J^#, Feng R^#, Zhao Z, Lu Q, Wang G, Li H, Su D, Zhou J*, Jing Q*, Jing Z*. Circulating microRNAs: a novel potential biomarker for diagnosing acute aortic dissection. Sci Rep 2017 Oct 6;7(1):12784
13. Qiu XX, Liu Y, Zhang YF, Guan YN, Jia QQ, Wang C, Liang H, Li YQ, Yang HT, Qin YW, Huang S, Zhao XX, Jing Q*. Rapamycin and CHIR99021 Coordinate Robust Cardiomyocyte Differentiation From Human Pluripotent Stem Cells Via Reducing p53-Dependent Apoptosis. J Am Heart Assoc 2017 Oct 2;6(10):e005295
14. Li Y*, Zeng A, Li G, Guan YN, Yang HT, Shen B**, Jing Q*. Dynamic regulation of small RNAome during the early stage of cardiac differentiation from pluripotent embryonic stem cells. Genom Data 2017 May 3;12:136-145
15. Chen J, Zhu RF, Li FF, Liang YL, Wang C, Qin YW, Huang S, Zhao XX*, Jing Q*. MicroRNA-126a Directs Lymphangiogenesis Through Interacting With Chemokine and Flt4 Signaling in Zebrafish. Arterioscler Thromb Vasc Biol 2016 Dec;36(12):2381-2393
16. Zeng A, Li YQ, Wang C, Han XS, Li G, Wang JY, Li DS, Qin YW, Shi Y, Brewer G, Jing Q*. Heterochromatin protein 1 promotes self-renewal and triggers regenerative proliferation in adult stem cells. J Cell Biol 2013 Apr 29;201(3):409-425
17. Zou J, Li WQ, Li Q, Li XQ, Zhang JT, Liu GQ, Chen J, Qiu XX, Tian FJ, Wang ZZ, Zhu N, Qin YW, Shen B, Liu TX*, Jing Q*. Two Functional MicroRNA-126s Repress a Novel Target Gene P21-Activated Kinase1 to Regulate Vascular Integrity in Zebrafish. Circ Res 2011 Jan 21;108(2):201-209
18. Wang GK, Zhu JQ, Zhang JT, Li Q, Li Y, He J, Qin YW*, Jing Q*. Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans. Eur Heart J 2010 Mar;31(6):659-666