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JIN Ying

Ph.D.

Professor, Principal Investigator

Laboratory of Stem Cell Research

Email: yjin@sibs.ac.cn

Tel: 86-21-54923342

Research Areas:

Over the years, Dr. Jin’s group has investigated embryonic stem cells, especially human embryonic stem cells. They focuse on elucidating the regulatory mechanism governing self-renewal and pluripotency of embryonic stem cells, by addressing the question of how extracellular signals, intracellular transcriptional factors and epigenetic regulators coordinate to determine the cell fate of pluripotent stem cells. The goal is to understand the developmental principle and optimize the in vitro culture system of pluripotent stem cells. They are also interested in how human embryonic stem cells are directed to neural cell fate, particularly how to regionalize the neural progenitor cells in the central nervous system. All the effort would lay the foundation for the generation of clinical applicable functional cells.

Brief Biography:

2017 - Present: Professor, Principal Investigator, Shanghai Institute of Nutrition and Health, CAS

2002 - 2016: Professor, Principal Investigator, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine

2006 - 2016: Director of Key Laboratory of Stem Cell Biology, Chinese Academy of Sciences

1999 - 2002: Researcher, Developmental Biology Research Laboratory of Shanghai JiaoTong University School of Medicine

1994 - 1998: Research fellow, Molecular Immunology Center, Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas

1988-1994: Postdoctoral fellow, Department of Pharmacology, The University of North Texas Health Science Center, Fort Worth, Texas

1983 - 1988: Ph.D., Peking Union Medical College (PUMC) and Chinese Academy of Medical Science (CAMS)

Selected Publications: (*Corresponding Author)

  1. Sun Y, Zhang L, Fang Z, Liu D, Shao M, Liu Y, Liao B, Jin Y*. PRPF8 controls alternative splicing of PIRH2 to modulate the p53 pathway and survival of human ESCs. J Cell Physiol 2023 Jun 25. doi: 10.1002/jcp.31066.<.li>
  2. Chen H, Zeng Y, Shao M, Zhao H, Fang Z, Gu J, Liao B, Jin Y*. Calcineurin A gamma and NFATc3/SRPX2 axis contribute to human embryonic stem cell differentiation. J Cell Physiol 2021 Aug;236(8):5698-5714.
  3. Ding J, Fang Z, Liu X, Zhu Z, Wen C, Wang H, Gu J, Li QR, Zeng R, Li H, Jin Y*. CDK11 safeguards the identity of human embryonic stem cells via fine-tuning signaling pathways. J Cell Physiol 2020 May;235(5):4279-4290.
  4. Li T, Zhao H, Han X, Yao J, Zhang L, Guo Y, Shao Z, Jin Y*, Lai D*. The spontaneous differentiation and chromosome loss in iPSCs of human trisomy 18 syndrome. Cell Death Dis 2017;8(10):e3149.
  5. Xiao F, Liao B, Hu J, Li S, Zhao H, Sun M, Gun J, Jin Y*. Jmjd1c Ensures Mouse Embryonic Stem Cell Self-renewal and Somatic Cell Reprogramming through Controlling MicroRNA expression. Stem Cell Rep 2017;9(3):927-942.
  6. Wang L, Yu H*, Cheng H, He K, Fang Z, Ge L, Cheng T, Jin Y*. Deletion of Stk40 impairs definitive erythropoiesis in the mouse fetal liver. Cell Death Dis 2017;8(3):e2722.
  7. Wen J, Zeng Y, Fang Z, Gu J, Ge L, Tang F, Qu Z, Hu J, Cui Y, Zhang K, Wang J, Li S, Sun Y, Jin Y*. Single-cell analysis reveals lineage segregation in early post-implantation mouse embryos. J Biol Chem 2017;292(23):9840-9854.
  8. Zhao H, Han Z, Liu X, Gu J, Tang F, Wei G, Jin Y*. The chromatin remodeler protein Chd4 maintains embryonic stem cell identity by controlling pluripotency- and differentiation-associated genes. J Biol Chem 2017;292(20):8507-8519.
  9. Zhu Z, Li C, Zeng Y, Ding J, Qu Z, Gu J, Ge L, Tang F, Huang X, Zhou C, Wang P, Zheng D, Jin Y*. PHB associates with the HIRA complex to control an epigenetic-metabolic circuit in human ESCs. Cell Stem Cell 2017;20(2):274-289.
  10. He K, Hu J, Yu H, Wang L, Tang F, Gu J, Ge L, Wang H, Li S, Hu P, Jin Ying*. Serine/threonin kinase 40 (Stk40) functions as a novel regulator of skeletal muscle differentiation. J Biol Chem 2017;292(1):351-360.
  11. Zhou C, Yang X, Sun Y, Yu H, Zhang Y*, Jin Y*. Comprehensive profiling reveals mechanisms of SOX2-mediated cell fate specification in human ESCs and NPCs. Cell Res 2016;26(2):171-189.
  12. Sun M, Liao B, Tao Y, Chen H, Xiao F, Gu J, Gao S, Jin Y*. Calcineurin-NFAT signaling controls somatic cell reprogramming in a stage-dependent manner. J Cell Physiol 2015;231(5):1151-1162.
  13. Qu Z, Guan Y, Cui L, Song J, Gu J, Zhao H, Xu L, Lu L, Jin Y*, Xu G*. Transplantation of rat embryonic stem cell-derived retinal progenitor cells preserves the retinal structure and function in rat retinal degeneration. Stem Cell Res Ther 2015;6:219-237.
  14. Yu H, He K, Wang L, Hu J, Gu J, Zhou C, Lu R, Jin Y*. Stk40 represses adipogenesis through translational control of CCAAT/enhancer-binding proteins. J Cell Sci 2015;128(15):2881-2890.
  15. Zhu L, Zhang S, Jin Y*. Foxd3 suppresses NFAT-mediated differentiation to maintain self-renewal of embryonic stem cells. EMBO Rep 2014;15(12):1286-1296.
  16. Guan Y, Cui L, Qu Z, Lu L, Wang F, Wu Y, Zhang J, Gao F, Tian H, Xu L, Xu G, Li W*, Jin Y*, Xu G*. Subretinal transplantation of rat MSCs and erythropoietin gene modified rat MSCs for protecting and rescuing degenerative retina in rats. Curr Mol Med 2013;13(9):1419-1431.
  17. Yang H, Liu Z, Ma Y, Zhong C, Yin Q, Zhou C, Shi D, Cai Y, Zhao H, Wang H, Tang F, Wang Y, Zhang C, Lai D, Jin Y*, Sun Q*, Li J*. Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes. Cell Res 2013;23(10):1187-1200.
  18. Zhou Y, Jiang H, Gu J, Tang Y, Shen N, Jin Y*. MicroRNA-195 targets ADP-ribosylation factor like protein 2 inducing apoptosis in human embryonic stem cell-derived neural progenitor cells. Cell Death Dis 2013;4:e695-706.
  19. Cui L, Guan Y, Qu Z, Zhang J, Liao B, Ma B, Qian J, Li D, Li W, Xu G*, Jin Y*. Wnt signaling determines tumorigenicity and function of ESC-derived retinal progenitors. J Clin Invest 2013;123(4):1647-1661.
  20. Liao B, Zhong, X, Xu H, Xiao F, Fang Z, Gu J, Chen Y, Zhao Y, Jin Y*. Itch, an E3 ligase of Oct4, is required for embryonic stem cell self-renewal and pluripotency induction. J Cell Physiol 2013;228(7):1443-1451.
  21. Yu H, He K, Li L, Sun L, Tang F, Li R, Ning W, Jin Y*. Deletion of Stk40 in the mouse causes respiratory failure and death at birth. J Biol Chem 2013;288(8):5342-5352.
  22. Ma Y, Li C, Gu J, Tang F, Li C, Li P, Ping P, Yang S, Li Z*, Jin Y*. Aberrant gene expression profiles in pluripotent stem cells induced fro fibroblasts of a Klinefelter syndrome patient. J Biol Chem 2012;287(46):38970-38979.
  23. Ma Y, Gu J, Li C, Wei X, Tang F, Shi G, Jiang J, Kuang J, Li J, Wang Z, Xie X, Jin Y*. Human foreskin fibroblast produces interleukin-6 to support derivation and self-renewal of mouse embryonic stem cells. Stem Cell Res Ther 2012;3(4):29-40.
  24. Zhang H, Ma Y, Gu J, Liao B, Li J, Wong J*, Jin Y*. Reprogramming of somatic cells via TAT-mediated protein transduction of recombinant factors. Biomaterials 2012;33(20):5047-5055.
  25. Yang A, Shi G, Zhou C, Lu R, Li H, Sun L, Jin Y*. Nucleolin maintains embryonic stem cell self-renewal by suppression of p53 protein-dependent pathway. J Biol Chem 2011;286(50):43370-43382.
  26. Shi G, Gao F, Jin Y*. The regulatory role of histone deacetylase inhibitors in Fgf4 expression is dependent on the differentiation state of pluripotent stem cells. J Cell Physiol 2011;226(12):3190-3196.
  27. Lu R, Yang A, Jin Y*. Dual functions of T-box3 in the control of self-renewal and extraembryonic endoderm differentiation in mouse embryonic stem cells. J Biol Chem 2011;286(10):8425-8436.
  28. Li X, Zhu L, Yang A, Lin J, Tang F, Jin S, Wei Z, Li J, Jin Y*. Calcineurin-NFAT signaling critically regulates early lineage specification in mouse embryonic stem cells and embryos. Cell Stem Cell 2011;8(1):46-58.
  29. Fang H, Yang Y, Li C, Fu S, Yang Z, Jin G, Wang, K, Zhang J*, Jin Y*. Transcriptome analysis of early organogenesis in human embryos. Dev Cell 2010;19(1):174-184.
  30. Li C, Yang Y, Lu X, Sun Y, Gu J, Feng Y, Jin Y*. Efficient derivation of Chinese human embryonic stem cell lines from frozen embryos. In Vitro Cell Dev Biol Anim 2010;46(3-4):186-191.
  31. Li L, Sun L, Gao F, Jiang J, Yang Y, Li C, Gu J, Wei Z, Yang A, Lu R, Ma Y, Tang F, Kwon S, Zhao Y, Li J, Jin Y*. Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation. PNAS 2010;107(4):1402-1407.
  32. Liao B, Jin Y*. Wwp2 mediates Oct4 ubiquitination and its auto-ubiquitination in a dosage-dependent manner. Cell Res 2010;20(3):332-344.

Collaborative Publications:

  1. Shan J, Zhao B,Shan Z,Nie J,Deng R, Xiong R, Tsun A, Pan W, Zhao H, Chen L, Jin Y, Qian Z, Lui K, Li B*. Histone restricts influenza A virus infection by erasing IFITM3-K88 demethylase LSD1 monomethylation. PLOS Pathogens 2017;13(12):e1006773.
  2. Ju X, Hou Q, Sheng A, Wu K, Zhou Y, Jin Y, Wen T, Yang Z, Wang X, Luo Z*. The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice. Elife 2016;5:e18197-18222.
  3. Fang L, Zhang J, Zhang H, Yang X, Jin X, Zhang L, Skalnik D, Jin Y, Zhang Y, Huang X, Li J, Wong J*. H3K4 methyltransferase Set1a is a key Oct4 coactivator essential for generation of Oct4 positive inner cell mass. Stem Cells 2016;34(3):565-580.
  4. Hu W, Qiu B, Guan W, Wang Q, Wang M, Li W, Gao L, Shen L, Huang Y, Xie G, Zhao H, Jin Y, Tang B, Yu Y*, Zhao J*, Pei G*. Direct Conversion of Normal and Alzheimer’s Disease Human Fibroblasts into Neuronal Cells by Small Molecules. Cell Stem Cell 2015;17(2):204-212.
  5. Zhang Y, Xie S, Zhou Y, Xie Y, Liu P, Sun M, Xiao H, Jin Y, Sun X, Chen Z, Huang Q, Chen S. H3K36 histone methyltransferase Setd2 is required for murine embryonic stem cell differentiation toward endoderm. Cell Rep 2014;8(6):1989-2002.
  6. Yang Y, Liao B, Wang S, Yan B, Jin Y, Shu H, Wang Y*. E3 ligase WWP2 negatively regulates TLR3- mediated innate immune response by targeting TRIF for ubiquitination and degradation. P Natl Acad Sci USA 2013;110(13):5115-5120.
  7. Cao N, Liu Z, Chen Z, Wang J, Chen T, Zhao X, Ma Y, Qin L, Kang J, Wei B, Wang L, Jin Y, Yang H*. Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells promoting the proliferation of cardiac progenitor cells. Cell Res 2012;22(1):219-236.
  8. Fang H, Jin W, Yang Y, Jin Y, Zhang J*, Wang K*. An organogenesis network-based comparative transcriptome analysis for understanding early human development in vivo and in vitro. BMC Syst Biol 2011;5:108-119.
  9. Li Q, Xing X, Chen T, Li R, Dai J, Sheng Q, Xin S, Zhu L, Jin Y, Pei G, Kang J, Li Y, Zeng R*. Large Scale Phosphoproteome Profiles Comprehensive Features of Mouse Embryonic Stem Cells. Mol Cell Proteomics 2011;10(4):1-14.
  10. International Stem Cell Initiative, Amps K, Andrews PW, Anyfantis G, Armstrong L, Avery S, Baharvand H, Baker J, Baker D, Munoz MB, Beil S, Benvenisty N, Ben-Yosef D, Biancotti JC, Bosman A, Brena RM, Brison D, Caisander G, Camarasa MV, Chen J, Chiao E, Choi YM, Choo AB, Collins D, Colman A, Crook JM, Daley GQ, Dalton A, De Sousa PA, Denning C, Downie J, Dvorak P, Montgomery KD, Feki A, Ford A, Fox V, Fraga AM, Frumkin T, Ge L, Gokhale PJ, Golan-Lev T, Gourabi H, Gropp M, Lu G, Hampl A, Harron K, Healy L, Herath W, Holm F, Hovatta O, Hyllner J, Inamdar MS, Irwanto AK, Ishii T, Jaconi M, Jin Y, Kimber S, Kiselev S, Knowles BB, Kopper O, Kukharenko V, Kuliev A, Lagarkova MA, Laird PW, Lako M, Laslett AL, Lavon N, Lee DR, Lee JE, Li C, Lim LS, Ludwig TE, Ma Y, Maltby E, Mateizel I, Mayshar Y, Mileikovsky M, Minger SL, Miyazaki T, Moon SY, Moore H, Mummery C, Nagy A, Nakatsuji N, Narwani K, Oh SK, Oh SK, Olson C, Otonkoski T, Pan F, Park IH, Pells S, Pera MF, Pereira LV, Qi O, Raj GS, Reubinoff B, Robins A, Robson P, Rossant J, Salekdeh GH, Schulz TC, Sermon K, Sheik Mohamed J, Shen H, Sherrer E, Sidhu K, Sivarajah S, Skottman H, Spits C, Stacey GN, Strehl R, Strelchenko N, Suemori H, Sun B, Suuronen R, Takahashi K, Tuuri T, Venu P, Verlinsky Y, Ward-van Oostwaard D, Weisenberger DJ, Wu Y, Yamanaka S, Young L, Zhou Q. Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol 2011;29(12):1132-1144.
  11. Zhang X, Huang C, Chen J, Pankratz M, Xi J, Li J, Yang Y, LaVaute T, Li X, Ayala M, Bondarenko G, Du Z, Jin Y, Golos T, Zhang S*. Pax6 is a human neuroectoderm cell fate determinant. Cell Stem Cell 2010;7(1):90-100.

Invitation Review:

  1. Zhao H, Jin Y*. Signaling networks in the control of pluripotency. Current Opinion in Genetics & Development 2017;46:141-148.
  2. Zhang H, Jin Y*. Mouse induced pluripotent stem cells. In: J.Z. Kubiak (ed.), Mouse Development, Results and Problems in Cell Differentiation 55, DOI 10.1007/978-3-642-30406-4_20, Springer-Verlag Berlin Heidelber 2012, pages 395-411.
  3. Zhou Y, Jin Y*. Differentiation of Human Embryonic Stem Cells into Neural Lineage Cells. In M.A. Hayat (ed.), Stem Cells and Cancer Stem Cells 2012;7:229-239.
  4. Shi G, Jin Y*. Role of Oct4 in maintaining and regaining stem cell pluripotency. Stem Cell Res Ther 2010;1(5):39.