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HU Guohong


Professor, Principal Investigator

Laboratory of Tumor Metastasis

Email: ghhu@sinh.ac.cn

Tel: 86-21-54923296

Research Areas:

We are interested in elucidating how and where cancer cells metastasize. We primarily aim to study the molecular mechanisms governing tumor adaptation and remodeling of distant microenvironment for metastatic colonization, and how these processes can be prevented and reversed. Recently we are working on the followingspecific aspects regarding tumor-microenvironment interaction: (1) the regulation of breast cancer metastasis organotropism; (2) cancer stem cell heterogeneity and metastasis regulation; (3) glucose and lipid metabolic regulation during metastasis.


Brief Biography:

2017-Present: Professor, Principal Investigator, President Assistant, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences

2009-2016: Professor, Principal Investigator, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine

2005-2009: Postdoctoral Research Associate/Associate Research Scholar, Department of Molecular Biology, Princeton University, Princeton, NJ, USA

2000-2005: Ph.D. of Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA

1996-2000: B.S. of Biology, Tsinghua University, Beijing, China


Selected Publications: (*Co-corresponding author; #Co-first author)

  1. Wu Q, Tian P, He D, Jia Z, He Y, Luo W, Lv X, Wang Y, Zhang P, Liang Y, Zhao W, Qin J, Su P, Jiang YZ, Shao ZM, Yang Q*, Hu G*. SCUBE2 mediates bone metastasis of luminal breast cancer by modulating immune-suppressive osteoblastic niches. Cell Res 2023 Jun;33(6):464-478
  2. Wang Y, Jia Z, Liang C, He Y, Cong M, Wu Q, Tian P, He D, Miao X, Sun B, Yin Y, Peng C, Yao F, Fu D, Liang Y, Zhang P*, Xiong H*, Hu G*. MTSS1 curtails lung adenocarcinoma immune evasion by promoting AIP4-mediated PD-L1 monoubiquitination and lysosomal degradation. Cell Discov 2023 Feb 21;9(1):20
  3. He Y, Luo W, Liu Y, Wang Y, Ma C, Wu Q, Tian P, He D, Jia Z, Lv X, Ma YS, Yang H, Xu K, Zhang X, Xiao Y, Zhang P, Liang Y, Fu D*, Yao F*, Hu G*. IL-20RB mediates tumoral response to osteoclastic niches and promotes bone metastasis of lung cancer. J Clin Invest 2022 Oct 17;132(20):e157917
  4. Ma C, He D, Tian P, Wang Y, He Y, Wu Q, Jia Z, Zhang X, Zhang P, Ying H, Jin ZB, Hu G*. miR-182 targeting reprograms tumor-associated macrophages and limits breast cancer progression. Proc Natl Acad Sci U S A 2022 Feb 8;119(6):e2114006119
  5. Xiao Y#, Cong M#, Li J, He D, Wu Q, Tian P, Wang Y, Yang S, Liang C, Liang Y, Wen J, Liu Y, Luo W, Lv X, He Y, Cheng DD, Zhou T, Zhao W, Zhang P, Zhang X, Xiao Y, Qian Y, Wang H, Gao Q, Yang QC, Yang Q, Hu G*. Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation. Cancer Cell 2021 Mar 8;39(3):423-437.e7
  6. Li Y, Lv Z, Zhang S, Wang Z, He L, Tang M, Pu W, Zhao H, Zhang Z, Shi Q, Cai D, Wu M, Hu G, Lui KO, Feng J, Nieto MA, Zhou B. Genetic Fate Mapping of Transient Cell Fate Reveals N-Cadherin Activity and Function in Tumor Metastasis. Dev Cell 2020 Sep 14;54(5):593-607
  7. Zhang P, Liu Y, Lian C, Cao X, Wang Y, Li X, Cong M, Tian P, Zhang X, Wei G, Liu T*, Hu G*. SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation. Nat Commun 2020 May 19;11(1):2487
  8. Cong M, Wang Y, Yang Y, Lian C, Zhuang X, Li X, Zhang P, Liu Y, Tang J, Yang Q, Zhang X, Xiong H*, Hu R*, Hu G*. MTSS1 suppresses mammary tumor-initiating cells by enhancing RBCK1-mediated p65 ubiquitination. Nat Cancer 2020 Jan 20;1(2):222-234
  9. Ma Q, Wu K, Li H, Li H, Zhu Y, Hu G, Hu L, Kong X. ONECUT2 overexpression promotes RAS-driven lung adenocarcinoma progression. Sci Rep 2019 Dec 27;9(1):20021
  10. Zhuang X, Zhang H, Li X, Li X, Cong M, Peng F, Yu J, Zhang X, Yang Q*, Hu G*. Differential effects on lung and bone metastasis of breast cancer by Wntsignalling inhibitor DKK1. Nat Cell Biol 2017 Oct;19(10):1274-1285
  11. Huang H, Zhang W, Pan Y, Gao Y, Deng L, Li F, Li F, Ma X, Hou S, Xu J, Li P, Li X, Hu G, Li C, Chen H, Zhang L, Ji H*. YAP suppresses lung squamous cell carcinoma progression via deregulation of the DNp63-GPX2 axis and ROS accumulation. Cancer Res 2017 Nov 1;77(21):5769-5781
  12. Li N, Xue W, Yuan H, Dong B, Ding Y, Liu Y, Jiang M, Kan S, Sun T, Ren J, Pan Q, Li X, Zhang P, Hu G, Wang Y, Wang X, Li Q, Qin J*. AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis. J Clin Invest 2017 Apr 3;127(4):1284-1302
  13. Hu J#, Li G#, Zhang P, Zhuang X, Hu G*. A CD44v+ subpopulation of breast cancer stem-like cells with enhanced lung metastasis capacity. Cell Death Dis 2017 Mar 16;8(3):e2679
  14. Li G, Li M, Hu J, Lei R, Xiong H, Ji H, Yin H, Wei Q*, Hu G*. The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis. Oncogene 2017 Feb 16;36(7):989-998
  15. Yu PF, Huang Y, Xu CL, Lin LY, Han YY, Sun WH, Hu G, Rabson AB, Wang Y, Shi Y*. Downregulation of CXCL12 in mesenchymal stromal cells by TGFβ promotes breast cancer metastasis. Oncogene 2017 Feb 9;36(6):840-849
  16. Yu J#, Lei R#, Zhuang X, Li X, Li G, Lev S, Segura MF, Zhang X, Hu G*. MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells. Nat Commun 2016 Dec 20;7:13884
  17. Chen X, Cao X, Sun X, Lei, Chen P, Zhao Y, Jiang Y, Yin J, Chen R, Ye D, Wang Q, Liu Z, Liu S, Cheng C, Mao J, HouY, Wang M, SiebenlistUt, Chin E, Wang Y, Cao L, Hu G*, Zhang X*. Bcl-3 regulates TGFβ signaling by stabilizing Smad3 during breast cancer pulmonary metastasis. Cell Death Dis 2016 Dec 1;7(12):e2508
  18. Liang Y#, Hu J#, Li J, Liu Y, Yu J, Zhuang X, Mu L, Kong X, Hong D, Yang Q, Hu G*. Epigenetic activation of TWIST1 by MTDH promotes cancer stem-like Cell traits in breast cancer. Cancer Res 2015 Sep 1;75(17):3672-3680
  19. Chen F, Zhuang X, Lin L, Yu P, Wang Y, Shi Y, Hu G, Sun Y*. New horizons in tumor microenvironment biology: challenges and opportunities. BMC Med 2015 Mar 5;13:45
  20. Wei Q,Lei R, Hu G*. Roles of miR-182 in sensory organ development and cancer. Thorac Cancer 2015 Jan;6(1):2-9
  21. Wan L, Hu G, Wei Y, Yuan M, Bronson RT, Yang Q, Siddiqui J, Pienta KJ, Kang Y*. Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis. Cancer Res 2014 Sep 15;74(18):5336-5347
  22. Zhang N, Wang X, Huo Q, Sun M, Cai C, Liu Z, Hu G, Yang Q*. MicroRNA-30a suppresses breast tumor growth and metastasis by targeting metadherin. Oncogene 2014 Jun 12;33(24):3119-3128
  23. WangY, Lei R, Zhuang X, Zhang N, Pan H, Li G, Hu J, Pan X, Tao Q, Fu D, Xiao J, Chin E, Kang Y, Yang Q*, Hu G*. DLC1-dependent parathyroid hormone-like hormone inhibition suppresses breast cancer bone metastasis. J Clin Invest 2014 Apr;124(4):1646-1659
  24. Zhang N, Wang X, Huo Q, Li X, Wang H-Y, Schneider P, Hu G*, Yang Q*. The oncogene metadherin modulates the apoptotic pathway based on thetumor necrosis factor superfamily member TRAIL in breast cancer. J Biol Chem 2013 Mar 29;288(13):9396-9407
  25. Lei R#,Tang J#, Zhuang X, Deng R, Li G, Yu J, Liang Y, Xiao J, Wang H-Y, Yang Q, Hu G*. Suppression of MIM by microRNA-182 activates RhoA and promotes breast cancer metastasis. Oncogene 2014 Mar 6;33(10):1287-1296
  26. Lin B#, Wang Y#, Wang Z, Tan H, Kong X, Shu Y, Zhang Y, Huang Y, Zhu Y, Xu H, Wang Z, Wang P, Ning G, Kong X*, Hu G*, Hu L*. Uncovering the rare variants of DLC1 isoform 1 and their functional effects in a Chinese sporadic congenital heart disease cohort. PLoS One 2014 Feb 28;9(2):e90215
  27. Liang Y, Wu H, Lei R, Chong RA, Wei Y, Lu X, Tagkopoulos I, Kung S-Y, Yang Q, Hu G*, Kang Y*. Transcriptional network analysis identifies BACH1 as amaster regulator of breast cancer bone metastasis. J Biol Chem 2012 Sep 28;287(40):33533-33544
  28. Jin L#, Zhang Y#, Li H, Yao L, Fu D, Yao X, Xu L*, Hu X*, Hu G*. Differential secretomeanalysis reveals CST6 as a suppressor of breast cancer bone metastasis. Cell Res 2012 Sep;22(9):1356-1373
  29. Yu X, Wang F, Liu H, Adams G, Aikhionbare F, Liu D, Cao X, Fan L, Hu G, Chen Y, Frost A, Partridge E, Ding X, Yao X*. ACAP4 cooperates with GRB2 to orchestrate EGF-stimulated integrin beta1 recycling in cell migration. J Biol Chem 2011 Dec 23;286(51):43735-43747
  30. Liang Y, Fu D, Hu G*. MTDH: An emerging key regulator of malignant progression in multiple cancers. Thorac Cancer 2011 Nov;2(4):143-148
  31. Korpal M, Ell B, Buffa F, Khan Z, Blanco M, Hua Y, Wei Y, Hu G, Garcia B, Ragoussis J, Singh M, Harris A, Kang Y*. Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med 2011 Aug 7;17(9):1101-1108
  32. Shan J#, Budijono S#, Hu G#, Yao N, Kang Y, Ju Y*, Prud’homme R*. PEGylated composite nanoparticles containing upconverting phosphors and meso-tetraphenylporphine (TPP) for photodynamic therapy. Adv Funct Mater 2011 May 5;21(13):2488-2495
  33. Lu X, Yan C, Yuan M, Wei Y, Hu G, Kang Y*. In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropicmetastasis of breast cancer. Cancer Res 2010 May 15;70(10):3905-3914