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GAO Ying

MD,Ph.D.

Professor, Principal Investigator

Laboratory of Epigenetics and nutrition-related chronic diseases

Email: yinggao@sibs.ac.cn

Tel: 86-21-54920985

Research Areas: 

My lab is interested in exploring the complex interactions between nutritional factors and modifiable epigenetic factors, and the health outcomes across life span. My lab focuses on studying the roles of fatty acids intake and metabolism in metabolic disorder, cancer, growth and development with population based methods. We are also interested in searching novel epigenetic factors that interact with nutritional factors in the disease etiology. Our studies should provide novel insights into the etiology of these diseases. In the future we plan to conduct nutritional intervention studies to further evaluate the prevention/therapeutic potential of nutritional factors.  

  1. Use GC-MS and LC-MS to quantify the fatty acids profiles in human specimen from population-based studies, and evaluate the association between each fatty acid and health outcomes, including cancer, metabolic disorders, and growth and development of young children.  

  2. Use sequencing and other high through-put technology to assay genotype and DNA methylation variation, and explore the relationship between the genetic/epigenetic variations and cancer etiology with population-based studies. Cell and animal study will be conducted to validate the function of the top targets. 

  3. Conduct human dietary intervention studies to evaluate the health promoting effect of specific nutrient/food item. 

 

Brief Biography: 

2017-present: Professor, Principal Investigator, Shanghai Institute of Nutrition and Health (SINH), CAS 

2012-2016: Professor, Principal Investigator, Shanghai Institutes for Biological Sciences, CAS  

2007-2012: Postdoctoral fellow, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD  

2001-2007 Ph.D. , Nutrition, Division of Nutritional Sciences, Cornell University, Ithaca, NY 

2001-2007 M.S., Statistics, Department of Statistical Sciences, Cornell University, Ithaca, NY  

1998-2001 M.S., Nutrition, School of Public Health, Peking University, Beijing, China  

1998 M.D., Beijing Medical University, Beijing, China  

 

Selected Publications:*Corresponding Author 

  1. Jie Liu, ShengQuan Mi, Li Du, Xiang Li , Jing Zhao, Hong Zhang, WenHua Zhao* and Ying Gao* The association between plasma phytoestrogen concentration and metabolic syndrome risks in Chinese population, Plos One 2018 in press. 

  2. Peiqin Li, Jing Zhao, Kumar Kothapalli, Xiang Li, .Hui Li, Yuxuan Han, Shengquan Mi, Wenhua Zhao, Qizhai Li, Hong Zhang, Yiqing Song, J. Thomas Brenna, Ying Gao*. A regulatory insertion-deletion polymorphism in FADS gene cluster determines PUFA synthesis and influences lipid profiles. American Journal of Clinical Nutrition 2018 in press 

  3. Xiang Li, Hui Li, Jing Zhao, Qi Dai, Chaoran Huang, Langping Jin, Fan Yang, Fuxue Chen1, Ouchen Wang* and Ying Gao*. Plasma ω3_ and ω6_ fatty acids and thyroid diseases. Oncology Letters. 2017 in press 

  4. Xiao-fan Li, Jing Zhao, Peiqin Li, Ying Gao* Dairy products intake and endometrial cancer risk: a meta-analysis of observational studies. Nutrients 201710(1). pii: E25. doi: 10.3390/nu10010025. 

  5. Hui Li, Xiang Li, Jie Liu, Langping Jin, Fang Yang, Junbo Wang*Ouchen Wang*,Ying Gao*. Correlation between serum lead and thyroid diseases: papillary thyroid carcinoma, nodular goiter, and thyroid adenoma. International Journal of Environmental Health Research, 2017, 11:1-10 doi: 10.1080/09603123.2017.1373273 

  6. 李慧,郭倩颖,柳鹏,张岩春,戴智勇,高莹,王军波。不同时期母乳中脂肪酸水平的变化。中国食物与营养, 2017, 23 (5) :54-58  

  7. Hao Y, Zhao J, Wang K, Feng N, Sun P, Chen R, Kan H, Han B, Bai Z, Zhu Y, Gao Y*, Xia Z*. The Association between Particulate Matter Air Pollution and Respiratory Health in Elderly with Type 2 Diabetes Mellitus. Journal of Occupational and Environmental Medicine. 2017 ; 59(9):830-834 

  8. Du L, Wang Y, Zhang H, Zhang H, Gao Y*. Folate intake and the risk of endometrial cancerA meta-analysis. Oncotarget 2016, 7(51):85176-85184 

  9. Zhao J, Chen L, Gao J, Du L, Shan B, Zhang H, Wang H, and Gao Y*. Dietary fat intake and endometrial cancer risk: a dose-response meta-analysis. Medicine, 2016, 95(27):e4121 DOI: 10.1097/MD.0000000000004121 

  10. Liu J, Yuan F, Gao J, Shan B, Ren Y, Wang H, Gao Y*. Oral isoflavone supplementation on endometrial thickness: a meta-analysis of randomized placebo-controlled trials. Oncotarget 2016, 7(14):17369-79 

  11. Han J, Jiang Y, Liu X, Meng Q, Xi Q, Zhuang Q, Han Y, Gao Y, Ding Q, Wu G. Dietary Fat Intake and Risk of Gastric Cancer: A Meta-Analysis of Observational Studies. Plos One, 2015: 10(9):e0138580 

  12. Kristinsson S#, Gao Y#, Bjorkholm M, Lund S, Sjoberg J, Caporaso N, Goldin L, Landgren O. Hodgkin lymphoma risk following infectious and chronic inflammatory diseases: a large population-based case-control study from Sweden. Int J Hematol 2015;101(6):563-8 (# equal contribution) 

  13. Zhao J, Wang J, Du J, Xu H, Zhang W, Ni Q, Yu H, Risch H, Gao YT*, Gao Y*. Urinary prostaglandin E2 metabolite and pancreatic cancer risk: case-control study in urban Shanghai. Plos One, 2015:10(2):e0118004 

  14. Li W, Hu N, Wang Z, Yu K, Hyland P, Gao Y, Shi J, Chanock S, Burdette L, Ding T, Qiao Y, Fan J, Wheeler W, Xiong X, Tucker M, Dawsey S, Freedman N, Abnet C, Goldstein A, Taylor P. Genetic variants in DNA repair pathway genes and risk of esophageal squamous cell carcinoma and gastric adenocarcinoma in a Chinese population. Carcinogenesis, 2013; 34:1536-1542

  15. Gao Y*, Killian K, Zhang H, Yu K, Li QZ, Weinstein S, Virtamo J, Tucker M, Taylor P, Albanes D, Meltzer P, Caporaso N. Leukocyte DNA methylation and colorectal cancer among male smokers. World J Gastrointest Oncol. 2012;4:193-201 

  16. Capo-Ramos DE, Gao Y, Lubin JH, Check DP, Goldin LR, Pesatori AC, Consonni D, Bertazzi PA, Saxon AJ, Bergen AW, Caporaso NE, Landi MT. Mood disorders and risk of lung cancer in the EAGLE Case-control study and in the U.S. Veterans Affairs inpatient cohort. Plos One, 2012; 7:e42945

  17. Li Q, Pan D, Yue W, Gao Y, Yu K. Evaluating rare variants under two- stage design. J Hum Genet, 2012; 57:352-357 

  18. Park YJ, Herman H, Gao Y, Hu B, Lindroth AM, Soloway PD. Sequences sufficient for programming imprinted germ line DNA methylation defined. Plos One, 2012;7:e33024 

  19. Gao Y*, Katki H, Graubard B, Pollak M, Martin M, Tao Y, Schoen RE, Church T, Hayes RB, Greene MH, Berndt SI. Serum IGF1, IGF2, and IGFBP3 and risk of advanced colorectal adenoma. Int J Cancer, 2012; 131:E105-113 

  20. Gao Y*, Baccarelli A, Shu XO, Ji BT, Yu K, Tarantini L, Yang G, Li HL, Hou L, Rothman N, Zheng W, Gao YT, Chow WH. Blood leukocyte Alu and LINE-1 methylation and gastric cancer risk in the Shanghai Women’s Health Study. Br J Cancer, 2012; 106:585-591 

  21. Sitas F, Egger S, Urban MI, Taylor PR, Abnet CC, Boffetta P, O'Connell DL, Whiteman DC, Brennan P, Malekzadeh R, Pawlita M, Dawsey SM, Waterboer T; on behalf of the InterSCOPE Collaboration. InterSCOPE Study: Associations Between Esophageal Squamous Cell Carcinoma and Human Papillomavirus Serological Markers. J Natl Cancer Inst, 2012; 104: 147-158 

  22. Gao Y*, Hu N, Han XY, Ding T, Giffen C, Goldstein AM, Taylor PR. Risk factors for esophageal and gastric cancers in Shanxi Province, China: a case-control study. Cancer Epidemiol 2011; 35: e91-e99 

  23. Gao Y*, Hayes RB, Huang WY, Caporaso NE, Burdette L, Yeager M, Chanock SJ, Berndt SI. DNA repair gene polymorphisms and tobacco smoking in the risk for colorectal adenomas. Carcinogenesis 2011; 32:882-887 

  24. Gao Y*, Hu N, Han XY, Ding T, Giffen C, Goldstein AM, Taylor PR. Family history of cancer and risk for esophageal and gastric cancer in Shanxi, China. BMC Cancer 2009; 9:269 

  25. Gao Y*, Hu N, Han XY, Ding T, Giffen C, Goldstein AM, Taylor PR. Jasmine tea consumption and upper gastrointestinal cancer in China. Cancer Causes Control 2009; 20:1997-2007 

  26. Liang X, Gao Y, Lam T, Li Q, Falk K, Yang R, Goldstein A, Goldin L. Identifying rheumatoid arthritis susceptibility genes using high-dimensional methods. BMC Proc, 2009; 3: S79 

  27. Gao Y, Goldstein AM, Consonni D, Pesatori AC, Wacholder S, Tucker MA, Caporaso NE, Goldin L, Landi MT. Family history of cancer and nonmalignant lung diseases as risk factors for lung cancer. Int J Cancer 2009; 125:146-152 

  28. Gao Y*, Kristinsson SY, Goldin LR, Bj?rkholm M, Caporaso NE, Landgren O. Increased risk for non-Hodgkin lymphoma in individuals with celiac disease and a potential familial association. Gastroenterology 2009; 136: 91-98 

  29. Gao Y*, Linet MS, Gridley G, Mellemkjaer L, Hemminki K, Goldin LR, Landgren O. Shared susceptibility for celiac disease and inflammatory bowel disease? Scand J Gastroenterol 2008; 43:1279-1280