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Professor, Principal Investigator

Laboratory of Signal Transduction and Nutrition-related Diseases

Email: ychen3@sinh.ac.cn

Tel: 86-21-54920916

Research Areas:
Using molecular biology, cell biology, and animal models to explore the molecular mechanisms of metabolic diseases and tumorigenesis, signal transduction, and the relationship with human diseases. The research mainly focuses on the effects of spatial regulation of intracellular signal pathways on the biological functions of tumorigenesis and disorders of glucose and lipid metabolism.

Brief Biography:

1989–1994 Ph.D. Department of Medical and Molecular Genetics, Indiana University School of Medicine
1983–1986 M.S. Department of Pediatrics, West China University of Medical Sciences
1978–1983 B.S. Medical School at West China University of Medical Sciences

Academic Background
2017-at present: Vice President in Shanghai Institutes for Biological Sciences, CAS
2008-2016: Director in the Institute for Nutritional Sciences, CAS
2006-2008: Vice Director in the Institute for Nutritional Sciences, CAS
2017-at present: Professor, Principal Investigator in Shanghai Institute of Nutrition and Health (SINH), CAS
2004-2016: Professor, Principal Investigator in Shanghai Institutes for Biological Sciences, CAS
1998-2005: Indiana University School of Medicine as an Assistant Professor and Associate Professor
1994-1998: University of California at San Diego and Salk Institute as a postdoctoral fellow

Selected Publications: (*Corresponding Author)

  1. Bai M, Cao P, Lin Y, Yu P, Song S, Chen L, Wang L, Chen Y*. Intermittent Caloric Restriction Promotes Erythroid Development and Ameliorates Phenylhydrazine-Induced Anemia in Mice. Front Nutr 2022 Jun 9;9:892435.
  2. Lin Y, Bai M, Wang S, Chen L, Li Z, Li C, Cao P, Chen Y*. Lactate Is a Key Mediator That Links Obesity to Insulin Resistance via Modulating Cytokine Production From Adipose Tissue. Diabetes 2022 Apr 1;71(4):637-652.
  3. Zhao J, Bai M, Wei S, Li C, Lv Q*, Chen Y*. Improvement of Non-Alcoholic Fatty Liver Disease in Mice by Intermittent Use of a Fasting-Mimicking Diet. Mol Nutr Food Res 2021 Dec;65(23):e2100381.
  4. Song S, Bai M, Ling Z, Lin Y, Wang S, Chen Y*. Intermittent administration of a fasting-mimicking diet reduces intestinal inflammation and promotes repair to ameliorate inflammatory bowel disease in mice. J Nutr Biochem 2021 Oct;96:108785.
  5. Lin Y, Huang M, Wang S, You X, Zhang L, Chen Y*. PAQR11 modulates monocyte-to-macrophage differentiation and pathogenesis of rheumatoid arthritis. Immunology 2021 May;163(1):60-73.
  6. Bai M, Wang Y, Han R, Xu L, Huang M, Zhao J, Lin Y, Song S, Chen Y*. Intermittent caloric restriction with a modified fasting-mimicking diet ameliorates autoimmunity and promotes recovery in a mouse model of multiple sclerosis. J Nutr Biochem 2021 Jan;87:108493.
  7. Cao Q, You X, Xu L, Wang L, Chen Y*. PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy. Autophagy 2020 Jul;16(7):1236-1247.
  8. Xu L, You X, Cao Q, Huang M, Hong LL, Chen XL, Lei L, Ling ZQ, Chen Y*. Polyamine synthesis enzyme AMD1 is closely associated with tumorigenesis and prognosis of human gastric cancers. Carcinogenesis 2020 Apr 22;41(2):214-222.
  9. Wei S, Zhao J, Bai M, Li C, Zhang L, Chen Y*. Comparison of glycemic improvement between intermittent calorie restriction and continuous calorie restriction in diabetic mice. Nutr Metab (Lond) 2019 Aug 28;16:60.
  10. Huang M, Zhao Z, Cao Q, You X, Wei S, Zhao J, Bai M, Chen Y*. PAQR3 modulates blood cholesterol level by facilitating interaction between LDLR and PCSK9. Metabolism 2019 May;94:88-95.
  11. Wei S#, Han R#, Zhao J, Wang S, Huang M, Wang Y, Chen Y*. Intermittent administration of a fasting-mimicking diet intervenes in diabetes progression, restores β cells and reconstructs gut microbiota in mice. Nutr Metab (Lond) 2018 Nov 20;15:80.
  12. Cao Q, Wang Z, Wan H, Xu L, You X, Liao L, Chen Y*. PAQR3 Regulates Endoplasmic Reticulum-to-Golgi Trafficking of COPII Vesicle via Interaction with Sec13/Sec31 Coat Proteins. iScience 2018 Nov 30;9:382-398.
  13. Wei S, Zhao J, Wang S, Huang M, Wang Y, Chen Y*. Intermittent administration of a leucine-deprived diet is able to intervene in type 2 diabetes in db/db mice. Heliyon 2018 Sep 27;4(9):e00830.
  14. Wang S, Huang M, You X, Zhao J, Chen L, Wang L, Luo Y, Chen Y*. Gut microbiota mediates the anti-obesity effect of calorie restriction in mice. Sci Rep 2018 Aug 29;8(1):13037.
  15. Zhao Z, Xu D, Wang Z, Wang L, Han R, Wang Z, Liao L, Chen Y*. Hepatic PPARα function is controlled by polyubiquitination and proteasome-mediated degradation through the coordinated actions of PAQR3 and HUWE1. Hepatology 2018 Jul;68(1):289-303.
  16. Guo W, You X, Wang X, Wang L, Chen Y*. A synthetic peptide hijacks the catalytic subunit of class I PI3K to suppress the growth of cancer cells. Cancer Lett 2017 Oct 1;405:1-9.
  17. Wang L, Zhang R, You X, Zhang H, Wei S, Cheng T, Cao Q, Wang Z, Chen Y*. The steady-state level of CDK4 protein is regulated by antagonistic actions between PAQR4 and SKP2 and involved in tumorigenesis. J Mol Cell Biol 2017 Oct 1;9(5):409-421.
  18. You X, Guo W, Wang L, Hou Y, Zhang H, Pan Y, Han R, Huang M, Liao L, Chen Y*. Subcellular distribution of RAD23B controls XPC degradation and DNA damage repair in response to chemotherapy drugs. Cell Signal 2017 Aug;36:108-116.
  19. Wang L, Pan Y, Huang M, You X, Guo F, Chen Y*. PAQR3 augments amino acid deprivation-induced autophagy by inhibiting mTORC1 signaling. Cell Signal 2017 May;33:98-106.
  20. Zhang Y, Hou Y, Liu C, Li Y, Guo W, Wu JL, Xu D, You X, Pan Y, Chen Y*. Identification of an adaptor protein that facilitates Nrf2-Keap1 complex formation and modulates antioxidant response. Free Radic Biol Med 2016 Aug;97:38-49.
  21. Xu D, Wang Z, Chen Y*. Two-layer regulation of PAQR3 on ATG14-linked class III PtdIns3K activation upon glucose starvation. Autophagy 2016 Jun 2;12(6):1047-1048.
  22. Xu DQ, Wang Z, Wang CY, Zhang DY, Wan HD, Zhao ZL, Gu J, Zhang YX, Li ZG, Man KY, Pan Y, Wang ZF, Ke ZJ, Liu ZX, Liao LJ, Chen Y*. PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity. EMBO J 2016 Mar 1;35(5):496-514.
  23. Xu D, Wang Z, Zhang Y, Jiang W, Pan Y, Song BL, Chen Y*. PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus. Nat Commun 2015 Aug 27;6:8100.
  24. Gu J, Zhang Y, Xu D, Zhao Z, Zhang Y, Pan Y, Cao P, Wang Z, Chen Y*. Ethanol-induced hepatic steatosis is modulated by glycogen level in the liver. J Lipid Res 2015 Jul;56(7):1329-1339.
  25. Liu G, Sun L, Pan A, Zhu M, Li Z, ZhenzhenWang Z, Liu X, Ye X, Li H, Zheng H, Ong CN, Yin H, Lin X, Chen Y*. Nickel exposure is associated with the prevalence of type 2 diabetes in Chinese adults. Int J Epidemiol 2015 Feb;44(1):240-248.
  26. Liu G, Zhang Y, Liu C, Xu D, Zhang R, Cheng Y, Pan Y, Huang C, Chen Y*. Luteolin alleviates alcoholic liver disease induced by chronic and binge ethanol feeding in mice. J Nutr 2014 Jul;144(7):1009-1015.
  27. Ling ZQ, Guo W, Lu XX, Zhu X, Hong LL, Wang Z, Wang Z, Chen Y*. A Golgi-specific protein PAQR3 is closely associated with the progression, metastasis and prognosis of human gastric cancers. Ann Oncol 2014 Jul;25(7):1363-1372.
  28. Jiang Y, Li X, Yang W, Hawke DH, Zheng Y, Xia Y, Aldape K, Wei C, Guo F, Chen Y, Lu Z. PKM2 regulates chromosome segregation and mitosis progression of tumor cells. Mol Cell 2014 Jan 9;53(1):75-87.
  29. Zhang Y, Xu D, Huang H, Chen S, Wang L, Zhu L, Jiang X, Ruan X, Luo X, Cao P, Liu W, Pan Y, Wang Z, Chen Y*. Regulation of glucose homeostasis and lipid metabolism by PPP1R3G-mediated hepatic glycogenesis. Mol Endocrinol 2014 Jan;28(1):116-126.
  30. Wang L, Wang X, Li Z, Xia T, Zhu L, Liu B, Zhang Y, Xiao F, Pan Y, Liu Y, Guo F, Chen Y*. PAQR3 has modulatory roles in obesity, energy metabolism, and leptin signaling. Endocrinology 2013 Dec;154(12):4525-4535.
  31. Zhang R, Huang H, Cao P, Wang Z, Chen Y*, Pan Y. Sma- and Mad-related protein 7 (Smad7) is required for embryonic eye development in the mouse. J Biol Chem 2013 Apr 12;288(15):10275-10285.
  32. Wang X, Wang L, Zhu L, Pan Y, Xiao F, Liu W, Wang Z, Guo F, Liu Y, Thomas WG, Chen Y*. PAQR3 modulates insulin signaling by shunting phosphoinositide 3-kinase p110α to the Golgi apparatus. Diabetes 2013 Feb;62(2):444-456.
  33. Huang H, Jin T, Wang L, Wang F, Zhang R, Pan Y, Wang Z, Chen Y*. The RAS guanyl nucleotide-releasing protein RasGRP1 is involved in lymphatic development in zebrafish. J Biol Chem 2013 Jan 25;288(4):2355-2364.
  34. Zhu L, Wang L, Luo X, Zhang Y, Ding Q, Jiang X, Wang X, Pan Y, Chen Y*. Tollip, an intracellular trafficking protein, is a novel modulator of the transforming growth factor-β signaling pathway. J Biol Chem 2012 Nov 16;287(47):39653-39663.
  35. Huang H, Jin T, He J, Ding Q, Xu D, Wang L, Zhang Y, Pan Y, Wang Z, Chen Y*. Progesterone and adipoQ receptor 11 links ras signaling to cardiac development in zebrafish. Arterioscler Thromb Vasc Biol 2012 Sep;32(9):2158-2170.
  36. Luo X, Zhang Y, Ruan X, Jiang X, Zhu L, Wang X, Ding Q, Liu W, Pan Y, Wang Z, Chen Y*. Fasting-induced protein phosphatase 1 regulatory subunit contributes to postprandial blood glucose homeostasis via regulation of hepatic glycogenesis. Diabetes 2011 May;60(5):1435-1445.
  37. Jiang Y, Xie X, Li Z, Wang Z, Zhang Y, Ling ZQ, Pan Y, Wang Z, Chen Y*. Functional cooperation of RKTG with p53 in tumorigenesis and epithelial-mesenchymal transition. Cancer Res 2011 Apr 15;71(8):2959-2968.
  38. Zhang Y, Jiang X, Qin X, Ye D, Yi Z, Liu M, Bai O, Liu W, Xie X, Wang Z, Fang J, Chen Y*. RKTG inhibits angiogenesis by suppressing MAPK-mediated autocrine VEGF signaling and is downregulated in clear-cell renal cell carcinoma. Oncogene 2010 Sep 30;29(39):5404-5415.
  39. Yang L, Zhang Y, Wang L, Fan F, Zhu L, Li Z, Ruan X, Huang H, Wang Z, Huang Z, Huang Y, Yan X, Chen Y*. Amelioration of high fat diet induced liver lipogenesis and hepatic steatosis by interleukin-22. J Hepatol 2010 Aug;53(2):339-347.
  40. Zhang C, Zhang M, Wang S, Han R, Cao Y, Hua W, Mao Y, Zhang X, Pang X, Wei C, Zhao G, Chen Y*, Zhao L*. Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice. ISME J 2010 Feb;4(2):232-241.
  41. Jiang Y, Xie X, Zhang Y, Luo X, Wang X, Fan F, Zheng D, Wang Z, Chen Y*. Regulation of G-protein signaling by RKTG via sequestration of the G betagamma subunit to the Golgi apparatus. Mol Cell Biol 2010 Jan;30(1):78-90.