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XIE Dong

Ph.D.

Professor, Principal Investigator

Laboratory of Tumor Molecular Biology

Email: dxie@sibs.ac.cn

Tel: 86-21-54920918

Research Areas:

Our major focus has been to investigate the role of a family of receptor tyrosine kinase (RTK), the Eph receptors and their ligands ephrins, and Eph interacting protein RACK1 in tumor initiation, cancer metastasis and cancer metabolism. Our approach involves a combination of oncogenomics and proteomics studies of primary tumor tissue from cancer patients, aluciferase-labeled orthotopic xenograft mouse models as well as traditional cell biology and biochemistry techniques. Ephs/ephrins represent important surface mediators, and many members showed aberrant expression in the process of tumorigenesis. We are interested to understand why Eph/ephrins and RACK1 are dysregulated during tumor transformation and metastasis, Which events downstream or upstream of Eph/ephrin happen associated with their alteration, and what is the underlying mechanism and transduction signaling pathways. Besides answering these questions, we search for optimal drug targets among Ephs/ephrins and Ephs/ephrins related molecules to develop strategy for cancer therapy.

 

Brief Biography:

2017 - Present Professor, Principal Investigator, Shanghai Institute of Nutrition and Health, CAS

2004-2016 Professor, Principal investigator, Institute of Nutritional Science, Chinese Academy of Science, Shanghai, China

2002-2004 Adjunct Assistant Professor, UCLA School of Medicine, UCLA, Los Angeles, California, USA

2000-2002 Research Scientist, Cedars-Sinai Medical Center, UCLA School of Medicine, UCLA, Los Angeles, California, USA

1997-2000 Postdoctoral Researcher, Cedars-Sinai Medical Center, UCLA School of Medicine, UCLA, Los Angeles, California, USA

1992-1997 Ph.D. Molecular Biology, University of South Carolina, South Carolina, USA

1989-1992 Lecturer, East China Institute of Technology, Jiangxi, China

1986-1989 M.S. Institute of Genetics, Chinese Academy of Sciences

1983-1986 Research Assistant, East China Institute of Technology, Jiangxi, China

1979-1983 B.S. Biology, Jiangxi University, Nanchang, China

 

Selected Publications: (*Corresponding Author)

  1. 1. Chen TW, Yin FF, Yuan YM, Guan DX, Zhang E, Zhang FK, Jiang H, Ma N, Wang JJ, Ni QZ, Qiu L, Feng J, Zhang XL, Bao Y, Wang K, Cheng SQ, Wang XF, Wang X, Li JJ, Xie D* (2019) Liver Cancer: CHML promotes metastasis by facilitating Rab14 recycle. Nat Commun 2019 Jun 7;10(1):2510. doi: 10.1038/s41467-019
  2. 2. Yuan YM, Ma N, Zhang EB, Chen TW, Jiang H, Yin FF, Wang JJ, Zhang FK, Ni QZ, Wang X, Bao Y, Wang K, Cheng SQ, Zhang XL, Wang XF, Li JJ, Xie D* (2019) BMP10 suppresses hepatocellular carcinoma progression via PTPRS-STAT3 axis. Oncogene 2019 Aug 15. doi: 10.1038/s41388-019-0943-y. [Epub ahead of print]
  3. 3. Deng YZ, Cai Z, Shi S, Jiang H, Shang YR, Ma N, Wang JJ, Guan DX, Chen TW, Rong YF, Qian ZY, Zhang EB, Feng D, Zhou QL, Du YN, Liu DP, Huang XX, Liu LM, Chin E, Li DS, Wang XF, Zhang XL, Xie D* (2018) Cilia loss sensitizes cells to transformation by activating the mevalonate pathway. J Exp Med 2;215(1):177-195
  4. 4. Cai Z, Qian ZY, Jiang H, Ma N, Li Z, Liu LY, Ren XX, Shang YR, Wang JJ, Li JJ, Liu DP, Zhang XP, Feng D, Ni QZ, Feng YY, Li N, Zhou XY, Wang X, Bao Y, Zhang XL, Deng YZ, Xie D* (2018) hPCL3s Promotes Hepatocellular Carcinoma Metastasis by Activating β-Catenin Signaling. Cancer Res 15;78(10):2536-2549
  5. 5. Zhou W, Ye XL, Xu J, Cao MG, Fang ZY, Li LY, Guan GH, Liu Q, Qian YH, Xie D* (2017) The lncRNA H19 mediates breast cancer cell plasticity during EMT and MET plasticity by differentially sponging miR-200b/c and let-7b. Science signaling 10(483). pii: eaak9557
  6. 6. Li JJ, Sun ZJ, Yuan YM, Yin FF, Bian YG, Long LY, Zhang XL, Xie D* (2017) EphB3 Stimulates Cell Migration and Metastasis in a Kinase-dependent Manner through Vav2-Rho GTPase Axis in Papillary Thyroid Cancer. J Biol Chem 292(3): 1112-1121
  7. 7. Bao WD, Fan Y, Deng YZ, Long LY, Wang JJ, Guan DX, Qian ZY, Feng YY, He ZY, Wang XF, Phillip Koeffler H, Hu R, Wang J, Wang X, Wang F, Li JJ, Xie D* (2016) Iron overload in hereditary tyrosinemia type 1 induces liver injury through the Sp1/Tfr2/hepcidin axis. J Hepatol 65(1):137-145
  8. 8. Guan DX, Shi J, Zhang Y, Zhao JS, Long LY, Chen TW, Zhang EB, Feng YY, Bao WD, Deng YZ, Qiu L, Zhang XL, Koeffler HP, Cheng SQ, Li JJ, Xie D* (2015) Sorafenib enriches epithelial cell adhesion molecule-positive tumor initiating cells and exacerbates a subtype of hepatocellular carcinoma through TSC2-AKT cascade. Hepatology 62(6):1791-1803
  9. 9. Li, JJ, Xie D* (2015) RACK1, a versatile hub in cancer. Oncogene 9;34(15):1890-1898
  10. 10. Long L, Deng Y, Yao F, Guan D, Feng Y, Jiang H, Li X, Hu P, Lu X, Wang H, Li J, Gao X, Xie D* (2014) Recruitment of Phosphatase PP2A by RACK1 Adaptor Protein Deactivates Transcription Factor IRF3 and Limits Type I Interferon Signaling. Immunity 40: 515-529
  11. 11. Yao F, Long LY, Deng YZ, Feng YY, Ying GY, Bao WD, Li G, Guan DX, Zhu YQ, Li JJ, Xie D* (2014) RACK1 Modulates NF-κB Activation by Interfering with the Interaction between TRAF2 and the IKK Complex. Cell Research 24(3):359-371
  12. 12. Zhang Y, Guan DX, Shi J, Gao H, Li JJ, Zhao JS, Qiu L, Liu J, Li N, Guo WX, Xue J, Zhou FG, Wu MC, Wang HY, Xie D*, Cheng SQ* (2013) All-trans retinoic acid potentiates the chemotherapeutic effect of Cisplatin by inducing differentiation of tumor initiating cells in liver cancer. J Hepatol 6:1255-1263
  13. 13. Yang, P., Li, Q.J., Feng, Y., Zhang, Y., Markowitz, G.J., Ning, S., Deng, Y., Zhao, J., Jiang, S., Yuan, Y., Wang, H.Y., Cheng, S.Q., Xie, D.*, and Wang, X.F.* (2012) TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma. Cancer Cell 22(3): 291-303
  14. 14. Li, G., Ji, X.D., Gao, H., Zhao, J.S., Xu, J.F., Sun, Z.J., Deng, Y.Z., Shi, S., Feng, Y.X., Zhu, Y.Q., Wang, T., Li, J.J., and Xie, D.* (2012) EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Aktsignalling complex. Nat Commun 3: 667
  15. 15. Deng, Y.Z., Yao, F., Li, J.J., Mao, Z.F., Hu, P.T., Long, L.Y., Li, G., Ji, X.D., Shi, S., Guan, D.X., Feng, Y.Y., Cui, L., Li, D.S., Liu, Y., Du, X., Guo, M.Z., Xu, L.Y., Li, E.M., Wang, H.Y., and Xie, D.* (2012) RACK1 suppresses gastric tumorigenesis by stabilizing the β-catenin destruction complex. Gastroenterology 142(4): 812-823.e815
  16. 16. Shi, S., Deng, Y.Z., Zhao, J.S., Ji, X.D., Shi, J., Feng, Y.X., Li, G., Li, J.J., Zhu, D., Koeffler, H.P., Zhao, Y., and Xie, D.* (2012) RACK1 promotes non-small-cell lung cancer tumorigenicity through activating sonic hedgehog signaling pathway. J Biol Chem 287(11): 7845-7858
  17. 17. Feng, Y.X., Wang, T., Deng, Y.Z., Yang, P., Li, J.J., Guan, D.X., Yao, F., Zhu, Y.Q., Qin, Y., Wang, H., Li, N., Wu, M.C., Wang, H.Y., Wang, X.F., Cheng, S.Q. and Xie, D.* (2011) Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model. Hepatology 53(2): 483-492
  18. 18. Ji, X.D., Li, G., Feng, Y.X., Zhao, J.S., Li, J.J., Sun, Z.J., Shi, S., Deng, Y.Z., Xu, J.F., Zhu, Y.Q., Koeffler, H.P., Tong, X.J., and Xie, D.* (2011) EphB3 is overexpressed in non-small-cell lung cancer and promotes tumor metastasis by enhancing cell survival and migration. Cancer Res 71(3): 1156-1166
  19. 19. Feng, Y.X., Zhao, J.S., Li, J.J., Wang, T., Cheng, S.Q., Yuan, Y., Wang, F., Wang, X.F., and Xie, D.* (2010) Liver cancer: EphrinA2 promotes tumorigenicity through Rac1/Akt/NF-kappaB signaling pathway. Hepatology 51(2): 535-544
  20. 20. Cai, Z., Zhao, J.S., Li, J.J., Peng, D.N., Wang, X.Y., Chen, T.L., Qiu, Y.P., Chen, P.P., Li, W.J., Xu, L.Y., Li, E.M., Tam, J.P., Qi, R.Z., Jia, W.*, and Xie, D.* (2010) A combined proteomics and metabolomics profiling of gastric cardia cancer reveals characteristic dysregulations in glucose metabolism. Mol Cell Proteomics 9(12): 2617-2628
  21. 21. Li, J.J., Liu, D.P., Liu, G.T., and Xie, D.* (2009) EphrinA5 acts as a tumor suppressor in glioma by negative regulation of epidermal growth factor receptor. Oncogene 28(15): 1759-1768
  22. 22. Wang, Y., Liu, D., Chen, P., Koeffler, H.P., Tong, X., and Xie, D.* (2008) Negative feedback regulation of IFN-gamma pathway by IFN regulatory factor 2 in esophageal cancers. Cancer Res 68(4): 1136-1143
  23. 23. Wang, Y., Liu, D.P., Chen, P.P., Koeffler, H.P., Tong, X.J., and Xie, D.* (2007) Involvement of IFN regulatory factor (IRF)-1 and IRF-2 in the formation and progression of human esophageal cancers. Cancer Res 67(6): 2535-2543
  24. 24. Deng, Y.Z., Chen, P.P., Wang, Y., Yin, D., Koeffler, H.P., Li, B., Tong, X.J., and Xie, D.* (2007) Connective tissue growth factor is overexpressed in esophageal squamous cell carcinoma and promotes tumorigenicity through beta-catenin-T-cell factor/Lef signaling. J Biol Chem 282(50): 36571-36581